A5069862906- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Food Allergy and Anaphylaxis Research
- Gastrointestinal disorders and treatments
- Veterinary medicine and infectious diseases
- Infant Nutrition and Health
- Gastrointestinal motility and disorders
- Intestinal and Peritoneal Adhesions
- Child Nutrition and Feeding Issues
- Celiac Disease Research and Management
- Congenital gastrointestinal and neural anomalies
- Esophageal and GI Pathology
- Intestinal Malrotation and Obstruction Disorders
- Clostridium difficile and Clostridium perfringens research
- Gastric Cancer Management and Outcomes
- Neonatal Respiratory Health Research
- Digestive system and related health
- Infant Health and Development
- Microscopic Colitis
- Pharmaceutical studies and practices
- Asthma and respiratory diseases
- Viral gastroenteritis research and epidemiology
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
Université de Lille
2008-2025
Hôpital Saint-Vincent-de-Paul
2013-2024
Groupe Hospitalier de l'Institut Catholique de Lille
2014-2024
Université Catholique de Lille
2005-2023
Université Paris Cité
2007-2021
Hôpital Necker-Enfants Malades
2013-2021
Assistance Publique – Hôpitaux de Paris
2007-2021
Hôpital Saint-Antoine
2001-2020
Sorbonne Université
2001-2020
Inserm
1998-2020
As the clinical implications of Helicobacter pylori infection in children and adolescents continue to evolve, ESPGHAN NASPGHAN jointly renewed guidelines using a standardized evidence-based approach develop updated recommendations for North America Europe.An international panel 11 pediatric gastroenterologists, 2 epidemiologists, 1 microbiologist, pathologist was selected by societies that developed based on Delphi process with anonymous voting final face-to-face meeting. A systematic...
<b>Aim:</b> To prospectively assess the antibacterial resistance rate in <i>Helicobacter pylori</i> strains obtained from symptomatic children Europe. <b>Methods:</b> During a 4-year period, 17 paediatric centres 14 European countries reported on patients infected with <i>H pylori</i>, for whom antibiotic susceptibility was tested. <b>Results:</b> A total of 1233 were Northern (3%), Western (70%), Eastern (9%) and Southern Europe (18%); 41% originated outside as indicated by mother's...
Premature birth results in a delayed and abnormal qualitative pattern of gut colonization. This is thought to affect intestinal development contribute higher risk gastrointestinal infectious diseases such as neonatal necrotizing enterocolitis (NEC). In particular, bifidobacteria are play major role. We therefore studied bifidobacterial colonization preterm infants during the first month life.Fecal samples were prospectively analyzed 52 born at gestational age ranging from 30 35 weeks fed...
Intestinal bacterial colonisation in pre-term infants is delayed compared with full-term infants, leading to an increased risk of gastrointestinal disease. Modulation through dietary supplementation probiotics or prebiotics could decrease such a risk. The present study evaluated clinical tolerance, the effects on gut microbiota, and inflammatory immunological mucosal responses infant formula adapted for that included its manufacturing process fermentation step two probiotic strains,...
<b>Background:</b> Reliable non-invasive methods for detection of <i>Helicobacter pylori</i> infection are required to investigate the incidence, transmission, and clearance in childhood. <b>Aim:</b> To evaluate a new monoclonal enzyme immunoassay (EIA) (FemtoLab H pylori Cnx) <i>H antigen stool large cohort children compared with invasive diagnostic <sup>13</sup>C urea breath test. <b>Patients methods:</b> A total 302 symptomatic previously untreated (aged 0.5–18.7 years; 148 girls) were...
ABSTRACT Objectives: To assess the safety of a polyethylene glycol (PEG) 4000 laxative without additional salts in pediatric patients. Study Design: This was 3‐month multicenter, randomized, double‐blind, double‐dummy, lactulose‐controlled, parallel study enrolling 96 ambulatory constipated children aged 6 months to 3 years, treated daily with 4‐8 g PEG or 3.33 g‐6.66 lactulose. Total protein, albumin, iron, electrolytes, and vitamins B9 (folates), A D (25OHD ) were measured blood before...
Helicobacter pylori is a human pathogen responsible for serious diseases including peptic ulcer disease and gastric cancer. The recommended triple therapy included clarithromycin but increasing resistance has undermined its effectiveness. It therefore important to be aware of the local prevalence antimicrobial adjust treatment strategy.Overall, 530 biopsies were collected between 2004 2007. susceptibility H. was determined by E-test molecular methods.Among these, 138/530 (26%) strains...
ABSTRACT Objectives: Recommendations for diagnosing and treating eosinophilic esophagitis (EoE) are evolving; however, information on real world clinical practice is lacking. To assess the practices of pediatric gastroenterologists EoE to identify triggering allergens in European children. Methods: Retrospective anonymized data were collected from 26 gastroenterology centers 13 countries. Inclusion criteria were: Patients diagnosis with EoE, completed investigations prescribed by physician,...
To look for evidence of intrafamilial infection, we isolated 107 Helicobacter pylori clones from biopsied specimens taken both parents and four children. We compared the sequences two housekeeping genes (hspA glmM) these with those 131 unrelated strains patients living in different geographic regions. Strain relationships within family were determined by analyzing allelic variation at loci building phylogenetic trees using multilocus sequence typing. Both hspA- glmM-based showed East Asian...
Background and Aim: Data on the eradication treatment for childhood Helicobacter pylori are scanty. A register was established European Society Pediatric Gastroenterology Hepatology Nutrition (ESPGHAN) website to collect data performed by pediatricians ascertain what is practiced in field. Subjects: From January 2001 December 2002, information 597 children were entered 23 Centers, but only of 518 treated completed analyzed (86.7%, 262 male subjects, median age 9 years, range 1–14). According...
ABSTRACT This study aimed to determine cutoff levels for fecal calprotectin as a marker of intestinal distress in preterm neonates. A total 126 infants born at median gestational age 33 weeks (range 25.7–35 weeks) were enrolled. Samples (n = 312) collected weekly from the end first week life until month and if any gastrointestinal event occurred. Receiver operating characteristic curves analysis gave values 363 μg/g (sensitivity 0.65, specificity 0.82) 636 0.72, 0.95) development mild or...
There are no solid figures of the frequency ulcer disease during childhood in Europe. We assessed its and analyzed known risk factors. Patients methods Ulcers, erosions, indications, factors were recorded all children undergoing an upper gastrointestinal endoscopy a prospective study carried out 1-month simultaneously 19 centers among 14 European countries. Results Ulcers and/or erosions observed 56 694 children. Children with ulcers/erosions significantly older than those without lesions...
The aim of the study was to compare sequential versus tailored triple therapy regimens on Helicobacter pylori (H pylori) eradication rates in children and assess effect antimicrobial susceptibility.Prospective, open-label, multicenter study. Children received randomly either a 10-day treatment comprising omeprazole (OME) with amoxicillin for 5 days OME, clarithromycin (CLA), metronidazole (MET) remaining days, or 7-day OME CLA cases CLA-susceptible strain MET CLA-resistant strain. H assessed...
Abstract Background: Food allergy is a common problem in France involving 4%–6% of toddlers. As opposed to IgE-mediated cow’s milk (CMA), delayed-onset CMA, mostly, non-IgE-mediated, remains difficult diagnose Our study assessed the diagnostic performances intestinal permeability and fecal markers, comparison with standard allergic work-up children referred for CMA diagnosis. Methods: Twenty-five consecutive children, mean age (standard deviation) 6.3 months (4.8) digestive and/or...