A5063164578- Helicobacter pylori-related gastroenterology studies
- Microscopic Colitis
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Inflammatory Bowel Disease
- Celiac Disease Research and Management
- Adolescent and Pediatric Healthcare
- Gastrointestinal disorders and treatments
- Galectins and Cancer Biology
- Autoimmune and Inflammatory Disorders Research
- Intestinal and Peritoneal Adhesions
- Gastrointestinal motility and disorders
- Immunodeficiency and Autoimmune Disorders
- Child Nutrition and Feeding Issues
- IL-33, ST2, and ILC Pathways
- Esophageal and GI Pathology
- Viral gastroenteritis research and epidemiology
- Genetic factors in colorectal cancer
- Childhood Cancer Survivors' Quality of Life
- Child and Adolescent Health
- Veterinary medicine and infectious diseases
- Food Allergy and Anaphylaxis Research
- Colorectal Cancer Screening and Detection
- Liver Diseases and Immunity
- Clostridium difficile and Clostridium perfringens research
Tampere University
2007-2018
Tampere University Hospital
2004-2018
South Karelia Central Hospital
2014-2015
Pediatrics and Genetics
2014
North Bristol NHS Trust
2012
University of Helsinki
1995-2009
Hôpital Saint-Louis
2009
Erasmus University Rotterdam
2008
Erasmus MC
2008
Tampere University of Applied Sciences
2000
<b>Aim:</b> To prospectively assess the antibacterial resistance rate in <i>Helicobacter pylori</i> strains obtained from symptomatic children Europe. <b>Methods:</b> During a 4-year period, 17 paediatric centres 14 European countries reported on patients infected with <i>H pylori</i>, for whom antibiotic susceptibility was tested. <b>Results:</b> A total of 1233 were Northern (3%), Western (70%), Eastern (9%) and Southern Europe (18%); 41% originated outside as indicated by mother's...
The incidence of inflammatory bowel disease (IBD) has been increasing in Western countries. In younger people, Crohn's (CD) predominates over ulcerative colitis (UC), but the finding is not universal. present study aimed to characterize only also clinical picture IBD from 1987 2003 a large pediatric population Finland.Data were collected patient discharge and medical records at 2 largest university hospitals Finland. covered total 619,340 children, representing 56% children <18 years old...
The present study aimed to characterize the incidence of pediatric inflammatory bowel disease (IBD) in Finland and determine its temporal trends.The patients' data were based on database Social Insurance Institution. New cases diagnosed with IBD at age <18 years between 1987-2003 included. Annual rates calculated per 100,000 populations (with 95% confidence intervals [CI]). country is divided into 21 hospital districts regional differences evaluated accordingly.The increased from 5 1987 15...
Colorectal cancer (CRC) is the commonest site for malignancy in Europe. The Commissioner Health wishes to promote screening colorectal, breast and cervical aim of this study was assess public knowledge CRC Europe likely take up free screening. To end 20 710 members from 21 European countries were interviewed by means a regular survey amongst consumers (Omnibus survey) using 13 stem questions. Forty-eight per cent thought population at equal risk CRC, only 57% aware age 54% family history as...
Background: The purpose was to examine the epidemiology of Helicobacter pylori infection in Finnish children and adolescents.Methods: Blood samples taken from healthy subjects (n = 461) 3–18 years old were studied cross-sectionally for presence H. antibodies. Additionally, blood drawn 1980, 1983, 1986, 1989 74 born 1977 tested. Serum IgG-class antibodies determined by an enzyme immunoassay.Results: In cross-sectional series mean antibody levels percentage seropositive increased with age....
BackgroundThe long-term sequelae of inflammatory bowel disease (IBD) may differ between children and adults. We evaluated the health status patients with pediatric onset IBD controls in early adulthood.
Summary Background The exclusion of oats from the diet in coeliac disease is controversial. Aim To study long‐term safety treatment children with disease. Methods Altogether 32 were enrolled a 2‐year controlled trial. Twenty‐three remission randomized either to or gluten challenge; when small bowel histological relapse was evident after challenge, gluten‐free including started. Furthermore, nine newly detected patients adopted an oat‐containing diet. Small mucosal morphology, CD3+, α β + and...
Long-term outcomes of restorative proctocolectomy for pediatric-onset ulcerative colitis are unclear.Questionnaires on health and quality life were mailed to patients with childhood-onset who had undergone ileoanal anastomosis in 2 university hospitals between 1985 2005. Investigators not involved the surgical management approached participants. Matched control children randomly chosen from Population Register Centre Finland.Fifty-two (66%) 117 (37%) controls responded. After a mean...
Over a 2.5-year period, 82 consecutive children complaining of recurrent abdominal pain underwent upper gastrointestinal endoscopy. Gastroscopy confirmed pathology in 48 the (58.5%). Four children, who also had undergone gastroscopy, other diagnoses (lactose malabsorption, hydronephrosis, yersinosis), and 30 (36.6%) retained initial diagnosis syndrome. Gastritis was found 18 whom (37.5%) positive test results for Helicobacter pylori, based on histology and/or culture. Of 16 H....
Both iron deficiency anaemia and Helicobacter pylori infection are rare in developed countries. A possible connection has been suggested between these two diseases our aim was to define the clinical picture study effect of bacterial eradication H. colonized children with severe anaemia.Eight refractory supplementation were examined gastroscopy because suspicion infection. Anaemia treated oral ferrous sulphate. Two patients needed blood transfusions. Eradication therapy given either...
Noninvasive, sensitive, and specific tools for early identification of chronic inflammatory bowel disease (IBD) are needed clinical practice. The aim was to identify new noninvasive test combinations characterization IBD in children adolescents by comparing serological responses microbial antigens fecal calprotectin, a promising marker intestinal inflammation.Our study included 73 who underwent endoscopies because suspicion IBD. Their sera were tested antibodies the Pseudomonas...
Study Objectives:To evaluate the frequency of sleep problems and daytime tiredness among adolescents with inflammatory bowel disease (IBD) in comparison their healthy peers.
ABSTRACT We identified a total of 595 Finnish children born in 1994–2008 and diagnosed as having inflammatory bowel disease (IBD) by October 2010 from the National Reimbursement Register (based on certificates including diagnostic criteria) to determine whether presence cow's milk allergy (CMA) or asthma is associated with risk contracting IBD (altogether 2380 matched controls). A diagnosis CMA infancy was Crohn (odds ratio [OR] 1.92, confidence interval [CI] 1.09–3.36, P < 0.05)...
Controlled trials considering the effect of Helicobacter pylori (H. pylori) eradication on gastrointestinal symptoms in children are scant. We aimed to study connection between recurrent abdominal pain and dyspepsia H. infection children.This was a double blind randomised controlled trial. Twenty with (RAP) being positive as measured C urea breath test (UBT) were randomized either receive omeprazole, amoxycillin clarithromycin (n = 10), or omeprazole 2 placebos 10) for 1 week after...
The consequences of chronic gastroesophageal reflux disease (GERD) starting in childhood have not been widely studied. Our aim was to evaluate the usefulness endoscopy primary diagnosis GERD and investigate long-term course this children.Between 1989 1999, 136 children had endoscoped because persisting symptoms GER. After exclusions (neurological impairment, infant GER), 96 subjects were included, files from 76 available for final evaluation. Twenty-four hour pH-monitoring performed...
BackgroundThe goal was to cross-sectionally assess fecal calprotectin after restorative proctocolectomy for pediatric-onset ulcerative colitis (UC).
The aim was to evaluate psychosocial symptoms and competence as reported by the parents adolescents themselves among patients with inflammatory bowel disease (IBD) in relation population-based controls. Standardized Achenbach questionnaires—Child Behavior Checklist (CBCL) for Youth Self-Report (YSR) adolescents—were sent Finnish families of IBD (age 10–18 years), their controls matched age, gender, place residence. final study group comprised 160 236 parents, respectively. According parent...
SUMMARY The function of jejunal intraepithelial γδ+ T cells is obscure, but they are commonly implicated as playing a role in inflammatory and autoimmune conditions. In coeliac disease (CoD), there controversial reports to gluten dependency these cells. We have now studied the small bowel mucosal cell densities, ratios CD3+ αβ+ during early development on gluten-free diet. Nine children initially excluded for CoD were followed up rebiopsy after 0.8–4.5 years showed deterioration. Further, 21...
The incidence of Helicobacter pylori infection in very young children was determined, based on the emergence specific IgG antibodies sequential serum samples from birth to 2 years age. risk acquiring H infancy as a result maternal exposure organism also assessed, determination cord-blood antibodies. Serum class were analysed cord blood 195 newborns and their follow up until age years. Maternal detected 21 (10.6%). These disappeared all but one child before 7 months no new seroconversions...
Children with recurrent abdominal pain and dyspeptic symptoms often present histological gastritis Helicobacter pylori infection. No specific symptomatology has been found, however, to discriminate H. positive from negative subjects. Certain differences exist in paediatric age groups, comparison adults. In terms of treatment, children also form a special entity because the long exposure time This article describes typical findings discusses their significance clinical point view.