A5080346176- Chronic Disease Management Strategies
- Platelet Disorders and Treatments
- Healthcare Systems and Reforms
- Health Systems, Economic Evaluations, Quality of Life
- Cellular transport and secretion
- Palliative Care and End-of-Life Issues
- HIV/AIDS Impact and Responses
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Grief, Bereavement, and Mental Health
- Circadian rhythm and melatonin
- Retinal and Macular Surgery
- Protein Kinase Regulation and GTPase Signaling
- Child Nutrition and Water Access
- Child and Adolescent Health
- Retinal Diseases and Treatments
- Healthcare Policy and Management
- Complement system in diseases
- Global Maternal and Child Health
- Childhood Cancer Survivors' Quality of Life
- Blood transfusion and management
- Blood groups and transfusion
- Breastfeeding Practices and Influences
- Sphingolipid Metabolism and Signaling
- Erythrocyte Function and Pathophysiology
Kamuzu Central Hospital
2023-2025
Kamuzu University of Health Sciences
2023-2025
University of Health Science
2023-2024
University of Malawi
2024
Sierra Leone Urban Research Centre
2021
Sanquin
2012-2018
Amsterdam UMC Location University of Amsterdam
2018
University of Amsterdam
2018
Vascular endothelial cells contain unique storage organelles, designated Weibel-Palade bodies (WPBs), that deliver inflammatory and hemostatic mediators to the vascular lumen in response agonists like thrombin vasopressin. The main component of WPBs is von Willebrand factor (VWF), a multimeric glycoprotein crucial for platelet plug formation. In addition VWF, several other components are known be stored WPBs, osteoprotegerin, monocyte chemoattractant protein-1 angiopoetin-2 (Ang-2). Here, we...
Background Multimorbidity is a growing global concern, affecting patient outcomes and healthcare costs. In low- middle-income countries, data on multimorbidity in primary care beyond prevalence limited. Our study explored the demographic clinical characteristics of among older people attending health Malawi. Methods We conducted cross-sectional analysis medical records from 15,009 patients aged ≥50 years across three hospitals Malawi (one tertiary, two district). Data 2019-2021 was analyzed...
Background The WHO primary palliative care strategy states that is ‘an ethical responsibility of health systems’ and calls for integration into public healthcare systems to achieve universal coverage. We aimed determine stakeholders’ perspectives on the necessary components considerations a feasible acceptable model integrated older people living with serious multimorbid illness in Sub-Saharan Africa. Methods conducted multicountry cross-sectional qualitative study Ghana, Malawi Zimbabwe....
Endothelial cells store VWF (von Willebrand factor) in rod-shaped secretory organelles, called Weibel-Palade bodies (WPBs). WPB exocytosis is coordinated by a complex network of Rab GTPases, effectors, and SNARE (soluble NSF attachment protein receptor) proteins. We have previously identified STXBP1 as the link between Rab27A-Slp4-a on WPBs proteins syntaxin-2 -3. In this study, we investigate function syntaxin-3 secretion.In human umbilical vein endothelial blood outgrowth (BOECs) from...
Sphingosine-1-phosphate (S1P) is an agonist for five distinct G-protein coupled receptors, that released by platelets, mast cells, erythrocytes and endothelial cells. S1P promotes cell barrier function induces release of cell-specific storage-organelles designated Weibel-Palade bodies (WPBs). S1P-mediated enhancement dependent on receptor 1 (S1PR1) mediated signaling events result in the activation small GTPase Rac1. Recently, we have reported Rac1 regulates epinephrine-induced WPB...
Abstract Background The global population is undergoing a significant surge in aging leading to increased susceptibility various forms of progressive illnesses. This phenomenon significantly impacts both individual health and healthcare systems. Low Middle Income Countries face particular challenges, as their Primary Health Care (PHC) settings often lack the necessary human material resources effectively address escalating demands older people. study set out explore experiences people living...
It is well established that exclusive breastfeeding can play a critical role in reducing child morbidity and mortality. Limited research has been done thus far on the practice perceptions of Sierra Leone, where more than 10 % children die before age five. This study aimed to gain understanding into explore both matters order develop recommendations for effective strategies promote Pujehun District, Southern Leone.This exploratory mixed-method included cross-sectional survey 194 mothers,...
Few interventions are documented to meet person-centred needs of older people with serious multimorbidity in low- and middle-income countries where access palliative care is limited. Most the these settings delivered by primary health workers.
Abstract The global population is undergoing a significant surge in aging leading to increased susceptibility various forms of progressive illnesses. This phenomenon significantly impacts both individual health and healthcare systems. Low Middle Income Countries face particular challenges, as their Primary Health Care (PHC) settings often lack the necessary human material resources effectively address escalating demands older people. study set out explore experiences people living with...
No abstract available.