A5082687901- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Peptidase Inhibition and Analysis
- Chemical Synthesis and Analysis
- Cancer therapeutics and mechanisms
- Epigenetics and DNA Methylation
- Dietary Effects on Health
- Immune cells in cancer
- Ferrocene Chemistry and Applications
- Macrophage Migration Inhibitory Factor
Semmelweis University
2020-2024
Institute of Biochemistry
2021
Recognition of stress and mobilization adequate "fight-or-flight" responses is key for survival health. Previous studies have shown that exposure Caenorhabditis elegans to pathogens or toxins simultaneously stimulates cellular detoxification aversive behavior. However, whether a coordinated regulation exists between cytoprotective behavioral defenses remains unclear.Here, we show C. high concentrations naturally attractive food-derived odors, benzaldehyde diacetyl, induces toxicity food...
In a search for novel therapeutic options head and neck squamous cell carcinomas (HNSCCs) generally treated with limited success, we synthesized series of erlotinib–chalcone molecular hybrids 1,2,3-triazole alkyne linkers evaluated them their anticancer activity on Fadu, Detroit 562 SCC-25 HNSCC lines. Time- dose-dependent viability measurements disclosed significantly increased efficiency the compared to 1:1 combination erlotinib reference chalcone. The clonogenic assay demonstrated that...
Imipridones, including ONC201, ONC206 and ONC212 (which are emblematic members of this class compounds developed by Oncoceutics) constitute a novel anticancer agents, with promising results in clinical trials. With the aim increasing ROS (reactive oxygen species) responsivity synthesized molecules, set ferrocene-imipridone hybrids were designed synthesized. Our strategy was motivated documented interplay between imipridone-triggered activation TRAIL (the tumor necrosis factor-related...
JAK/STAT pathway plays a well-known role in macrophage polarization, but other signaling routes may also be involved. The aim of this study was to identify new pathways and repolarize macrophages by selected protein kinase inhibitors. HL-60 derived were chosen as model cells human blood used for comparison. M1 M2 polarization HL60 promoted LPS + IFNγ (LIF) IL-4 treatments, respectively. In macrophages, mediated Erk1/2 p38 phosphorylation, while HSP27 phosphorylation involved polarization....
Our ongoing research focuses on developing imipridone derivatives capable of complete and selective eradication cancer cells after relatively short treatment. We have synthetized systematically designed novel hybrids evaluated their antiproliferative activity PANC-1 Fadu cell lines. also conducted preliminary studies the mechanism including colony formation as well dose-response tests in HEK293T wild-type (WT) CLPP-/- cells. Following gradual structural fine-tuning based high throughput...
Our ongoing research focuses on the development of new imipridone derivatives. We aim to design compounds that can completely and selectively eradicate cancer cells after relatively short treatment. have synthetized systematically designed novel hybrids evaluated their antiproliferative activity against PANC-1 Fadu cell lines. also conducted preliminary studies mechanism, including colony formation as well dose-response tests in HEK293T wild-type (WT) CLPP
Abstract Background Protection of organismal integrity involve physiological stress responses and behavioral defenses. Recent studies in the roundworm Caenorhabditis elegans have shown that pathogen toxin exposure simultaneously stimulate cellular detoxification aversive behavior. However, whether a coordinate regulation exists between neurobehavioral defenses remains unclear. Results Here we show C. to high concentrations naturally attractive food-derived odors, benzaldehyde diacetyl,...