A5013425297- Radiation Detection and Scintillator Technologies
- Medical Imaging Techniques and Applications
- Nuclear Physics and Applications
- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- Radiopharmaceutical Chemistry and Applications
- Particle Detector Development and Performance
- Advanced Optical Sensing Technologies
- Atomic and Subatomic Physics Research
- Viral Infectious Diseases and Gene Expression in Insects
- Cardiac Ischemia and Reperfusion
- Protein purification and stability
- Cardiac Imaging and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Blood properties and coagulation
- Insect Resistance and Genetics
- Cell Adhesion Molecules Research
- Cardiac Arrhythmias and Treatments
- Effects of Radiation Exposure
- Cancer, Hypoxia, and Metabolism
- Liver physiology and pathology
- Earthquake and Tsunami Effects
- Advanced Fluorescence Microscopy Techniques
- Digital Radiography and Breast Imaging
Nagoya University
2016-2025
Mie University
2015-2022
Akita Red Cross Hospital
2020-2021
Nagoya City University
2017
Osaka Medical Center for Cancer and Cardiovascular Diseases
2012
Columbia University
1994-2004
University of North Carolina at Charlotte
1999
Hokkaido University
1996-1997
Sapporo City General Hospital
1997
Wake Forest University
1992-1993
Abstract In targeted alpha-particle therapy, actinium-225 (Ac-225) has emerged as a radionuclide of potential, driving extensive efforts to develop innovative radiopharmaceuticals. High-resolution imaging alpha particles is required for precisely detecting alpha-emitting radionuclides in cellular environments and small organs. Here, we report real-time trajectory emitted by Ac-225 its daughter radionuclides, utilizing an particle system. This system incorporates magnification unit, cooled...
BACKGROUND It has recently been demonstrated that myocardial ischemia and reperfusion results in a marked decrease the release of nitric oxide (NO) by coronary endothelium. NO may possess cardioprotective properties, possibly related to inhibition neutrophil-related activities. We tested hypothesis cysteine-containing donor compound, SPM-5185, would reduce infarct size inhibit activities (adherence vascular endothelium, accumulation). METHODS AND RESULTS The effects intracoronary infusion...
Abstract
SP-303, a large proanthocyanidin oligomer isolated from the latex of plant species Croton lechleri (Eupborbiaceae) has demonstrated broad activity against variety DNA and RNA viruses. In cell culture, SP-303 exhibits potent isolates laboratory strains respiratory syncytial virus (RSV), influenza A (FLU-A) parainfluenza (PIV). Parallel assays ribavirin showed comparable these also significant inhibitory herpesvirus (HSV) types 1 2, including herpesviruses resistant to acyclovir foscarnet....
Journal Article A1 Receptor mediated myocardial infarct size reduction by endogenous adenosine is exerted primarily during ischaemia Get access Zhi-Qing Zhao, Zhao The Cardiovascular Program, Department of Cardiothoracic Surgery. Bowman Gray School Medicine, Medical Center Boulevard, Winston-Salem, NC 27157. USA: Z-Q Zhao. K Nakanishi, D S McGee, P Tan, J Vinten-Johansen. Correspondence to Dr Search for other works this author on: Oxford Academic PubMed Google Scholar Katsuhiko Nakanishi...
Abstract Actinium-225 (Ac-225) is a promising alpha emitter for radionuclide therapy due to its remarkable clinical efficacy in treating prostate cancer. The daughter radionuclides of Ac-225 emit beta particles with energies exceeding the Cherenkov-light threshold, making it possible image them by detecting Cherenkov light. However, performance imaging Ac-225's has not been assessed through experiments or simulations. To address this, we evaluated using both phantom and A solution was placed...
Abstract Actinium-225 (Ac-225) is a promising alpha emitter for radionuclide therapy, with clinical applications expected to start soon. As Ac-225 introduced therapeutic use, imaging of and its daughter radionuclides could address challenges such as monitoring injection detecting contamination in settings. While small field-of-view (FOV) gamma camera potentially be useful scenarios, efficacy has not yet been thoroughly evaluated. In this study, we assessed the feasibility using FOV...
A high-performance Ce3+-doped (Gd, Tb)3(Ga, Al)5O12 (GTAGG: Ce) single crystal was engineered and characterized, demonstrating a high application potential for advanced X-ray imaging. transparent 1-inch diameter grown using the Czochralski method, significant advancement in large-scale scintillator production. Comprehensive characterization diffraction electron probe micro-analysis confirmed crystal's structural integrity. Photoluminescence radioluminescence spectroscopy demonstrated...
Abstract Although alpha particles exhibit a Bragg peak at the end of their range, it remains unclear whether this is accurately observed in scintillators due to non-proportional response particles. To address issue, we employed novel imaging method capture trajectories scintillator. Using Gd 3 Al 2 Ga O 12 (GAGG) scintillator irradiated with emitted from actinium-225 (Ac-225) and its daughter radionuclides, imaged magnifying unit combined high-sensitivity CCD camera. The trajectory images...
Retinol, a morphogen, has been shown to induce morphological changes in vascular endothelial cells, accompanied by an acute and specific accumulation of 80-kDa protein; purification characterization this retinol-induced protein (RIP) have revealed that it is transglutaminase. Endothelial cells from bovine carotid artery were cultured, treated with retinol, examined for morphology profiles. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis extracts prepared retinol-treated...
High-resolution imaging of alpha particles is required in the detection radionuclides cells or small organs for development radio-compounds targeted alpha-particle therapy other purposes. We developed an ultrahigh resolution, real time system observing trajectories a scintillator. The based on magnifying unit and cooled electron multiplying charge-coupled device (EM-CCD) camera, combined with 100-µm-thick Ce-doped Gd3Al2Ga3O12 (GAGG) scintillator plate. Alpha from Am-241 source were...
Abstract An imaging method that utilizes a scintillator plate combined with magnifying unit and cooled electron multiplying charge-coupled device (EM-CCD) camera shows promise for obtaining high-resolution trajectory images. However, it is not yet clear whether the ranges of images change energy alpha particles. Additionally, remains unclear intensity affected by To address these questions in our research, we conducted experiments to capture particles varying levels. generate different...
Abstract An imaging technique utilizing a scintillator plate in conjunction with magnifying unit and cooled electron multiplying charge-coupled device (EM-CCD) camera shows promise for capturing high-resolution trajectory images. Nevertheless, the 2-dimensional images, incident directions of alpha particles entering remained unknown due to line-shaped trajectories. To elucidate our we conducted experiments images under off-focus conditions. capture particles, systematically varied distance...
Endothelial dysfunction is a prominent occurrence in coronary arteries after myocardial ischemia and reperfusion. However, this has not been studied veins. Endothelium-dependent vasorelaxation was cardiac venous rings obtained from dogs subjected to 60 min of artery occlusion followed by 270 reperfusion, as well sham ischemia-reperfusion. Myocardial resulted 96 +/- 2% decrease flow the ischemic area left anterior descending (LAD) artery, which led significant degree necrosis (i.e., 32.9 3.9%...
The dead-time loss reportedly degrades the accuracy of dosimetry using a gamma camera for targeted radionuclide therapy with Lu-177; therefore, needs to be corrected. However, correction is challenging. In this study, we propose novel and simple method shorten apparent dead time rather than correcting it through experiments Monte Carlo simulations. An energy window 208 keV ± 10 % generally used imaging Lu-177. Lower-energy photons X-rays Lu-177 do not contribute image formation but lead...
Because the sensitivity of positron emission tomography (PET) system increases in proportion to inverse diameter detector ring, brain PET systems are being planned and developed. However, count losses due dead-time blocks as ring decreases. Since decrease noise equivalent rate (NECR) system, NECR may be lower than that a whole-body clinical dose range. In this paper, we compared NECRs with using Monte Carlo simulation. We simulated for 27-cm-diameter 54-cm-diameter an 89-cm-diameter...
Abstract Objective . Precise monitoring of the position and dwell time iridium-192 (Ir-192) during high-dose-rate (HDR) brachytherapy is crucial to avoid serious damage normal tissues. Source imaging using a compact gamma camera potential approach for monitoring. However, images from are affected by blurring statistical noise, which impact accuracy source This study aimed develop deep-learning estimating ideal that reduce effect noise experimental captured camera. Approach A double pix2pix...
Abstract Objective . Prompt gamma photon, prompt x-ray, and induced positron imaging are possible methods for observing a proton beam’s shape from outside the subject. However, since these three types of images have not been measured simultaneously nor compared using same subject, their advantages disadvantages remain unknown beam shapes in therapy. To clarify points, we developed triple-imaging-modality system to measure photons, x-rays, positrons during irradiation phantom. Approach The...
Abstract It is known that scintillators exhibit non-proportional behavior between light output and the energy of gamma photons or beta particles. However, non-proportionality in alpha particles has not been extensively measured, likely due to challenges associated with preparing varying energies. To address this issue, we propose a novel method modulate using an americium-241 (Am-241) source covered different numbers Mylar films. By irradiating various scintillators, including GAGG, GGAG,...
Purpose Astatine‐211 (At‐211) is a promising alpha emitter for radionuclide therapy. High‐resolution in vivo imaging of At‐211 small animals needed the development radiopharmaceuticals. For this purpose, we developed low‐energy x‐ray camera using thin YAlO 3 :Ce (YAP(Ce)) plate to image x rays (73–87 keV) from daughter (Po‐211). Method We optically coupled 38 × 1‐mm YAP (Ce) position‐sensitive photomultiplier (PSPMT) develop an detector. A pinhole or parallel hole collimator was attached...