A5002792135- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Ovarian cancer diagnosis and treatment
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Breast Lesions and Carcinomas
- Colorectal and Anal Carcinomas
- Inflammatory Biomarkers in Disease Prognosis
- Helicobacter pylori-related gastroenterology studies
- Breast Cancer Treatment Studies
- Appendicitis Diagnosis and Management
- Breast Implant and Reconstruction
- Pancreatic and Hepatic Oncology Research
- Gut microbiota and health
- Gallbladder and Bile Duct Disorders
- Cancer Immunotherapy and Biomarkers
- Intestinal and Peritoneal Adhesions
- Genetic factors in colorectal cancer
- HER2/EGFR in Cancer Research
- Nutrition and Health in Aging
- Colorectal Cancer Surgical Treatments
- Clostridium difficile and Clostridium perfringens research
- Monoclonal and Polyclonal Antibodies Research
Medical University of Lublin
2019-2025
Since increasing evidence underlines the prominent role of systemic inflammation in carcinogenesis, burden index (IBI) has emerged as a promising biomarker to estimate survival outcomes among cancer patients. The IBI only been validated Eastern gastric (GC) patients; therefore, aim this study was evaluate prognostic Central European GC patients undergoing multimodal treatment. Ninety-three with histologically confirmed who underwent treatment between 2013 and 2021 were included. Patient...
To assess the rate of textbook outcome (TO) and oncological (TOO) in European population based on GASTRODATA registry.TO is a composite parameter assessing surgical quality strongly correlates with improved overall survival. Following standard treatment for locally advanced gastric cancer, TOO was proposed as optimal multimodal parameter.TO achieved when all following criteria were met: no intraoperative complications, radical resection according to surgeon, pR0 resection, retrieval at least...
The purpose of this study was to evaluate the feasibility and safety indocyanine green (ICG) fluorescence as an alternative traditional sentinel lymph node biopsy (SLNB) techniques in breast cancer (BC) patients undergoing neoadjuvant chemotherapy (NAC). Specifically, aimed assess identification rates effectiveness ICG axillary staging without use radioactive tracers. This retrospective included 71 BC treated with NAC, who underwent SLNB using between 2020 2024. injected intradermally around...
Although malignancies during pregnancy are relatively rare, breast cancer emerges as the most common neoplasm affecting pregnant women. Diagnostic workup and multimodal treatment of must be weighed against potential risk to fetus. With increasing number diagnoses pregnancy, this narrative review aimed outline epidemiological molecular background, followed by presenting available therapeutic options. Surgery remains choice among patients with pregnancy. However, systemic therapy based on...
In 2022, colorectal cancer (CRC) was the third most prevalent malignancy worldwide. The therapeutic approach for CRC typically involves a multimodal regimen. human gut microbiota comprises over 35,000 bacterial species. composition of is influenced by dietary intake, which plays crucial role in food absorption, nutrient extraction, and development low-grade inflammation. Dysbiosis key driver inflammation strongly associated with development. While microbiome influences initiation...
The ratio of positive lymph nodes (LNs) to the total LN harvest is called (LNR). It an independent prognostic factor in gastric cancer (GC). aim current study was evaluate impact neoadjuvant chemotherapy (NAC) on LNR (ypLNR) patients with advanced GC. We retrospectively analysed data GC, who underwent gastrectomy N1 and N2 (D2) lymphadenectomy between August 2011 January 2019 Department Surgical Oncology at Medical University Lublin. exclusion criteria were a lack preoperative NAC...
The prognostic value of the systemic inflammatory response markers, namely neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte (LMR), and platelet-to-lymphocyte (PLR) has not yet been clarified in patients undergoing neoadjuvant chemotherapy (NAC) gastrectomy for advanced gastric cancer (GC) Eastern European population. This study aimed to verify NLR, PLR, LMR GC multimodal treatment. One hundred six NAC between 2012 2020 were included. Analysed blood samples obtained prior (pre-NAC...
The 5th edition of the World Health Organization (WHO) classification tumors digestive system distinguishes four categories appendiceal (ATs): serrated lesions and polyps, mucinous neoplasms, adenocarcinomas, neuroendocrine neoplasms (NENs). differential diagnosis ATs can be challenging in medical practice, due to their rarity lack data from randomized controlled trials on a large, diverse group patients. are usually noted specimens obtained during appendectomies clinical acute appendicitis....
Peritoneal metastases (PM) of gastric cancer (GC) are characterized by a particularly poor prognosis, with median survival time 6 months, and virtually no 5-year reported. Conversion therapy for GC is defined as surgical treatment aiming at an R0 resection after systemic chemotherapy tumours that were originally unresectable (or marginally resectable) technical and/or oncological reasons. The aim the present study was to evaluate early late outcomes in patients PM who underwent cytoreductive...
The standard method for nodal staging in breast cancer (BC) patients after neoadjuvant chemotherapy (NAC) is sentinel lymph node biopsy (SLNB) with a radioisotope (RI) injection. However, SLNB NAC results high false-negative rates (FNR), and the RI restricted by nuclear medicine unit dependency. These limitations resulted development of superparamagnetic iron oxide (SPIO) method, reducing FNR presenting comparable detection rate. This bi-institutional cohort comparison study aimed to assess...
Sentinel lymph node biopsy (SLNB) is a well-established procedure for staging clinically node-negative early breast cancer (BC). Superparamagnetic iron oxide (SPIO) demonstrated efficacy nodal identification using magnetic probe after local retroaeroal interstitial injection. Its benefits lie in its flexibility, which an essential property the global setting, where access to isotope difficult. To best of our knowledge, this first study evaluate feasibility and safety SPIO SLNB BC patients...
The incidence of gastric cancer (GC) is expected to increase 1.77 million cases by 2040. To improve treatment outcomes, GC patients are increasingly treated with neoadjuvant chemotherapy (NAC) prior curative-intent resection. Although NAC enhances locoregional control and comprehensive patient care, survival rates remain poor, further investigations should establish outcomes assessment current clinical pathways. Individually assessed parameters have served as benchmarks for quality in the...
Cytokeratin-19 (CK19) has been proven to be commonly expressed by cancer cells in a variety of solid tumors and may serve as suitable marker metastases gastric (GC). Since objective assessment peritoneal lavage or fluid for free (FCC) is essential clinical decision making patients with GC, it important develop quantitative reproducible method such evaluation. We assessed the possible application One-Step Nucleic Acid amplification (OSNA) assay rapid FCC detection intraoperative GC patients....
Since esophagojejunostomy leak (EJL) after gastrectomy is a potentially fatal complication and may impact the survival of patients with advanced gastric cancer (GC), it important to establish risk factors for EJL prevent this surgical complication. The aim study was analysis predictors postoperative clinically apparent EJL. All operated GC between October 2016 December 2019 were analyzed from prospectively maintained database. evaluation complications according demographic clinical...
Introduction In the era of neoadjuvant chemotherapy in advanced gastric cancer (GC), role staging laparoscopy (SL) will become more established. However, despite guidelines recommendations, SL for optimal preoperative remains underutilized. Diagnostic value near-infrared (NIR) / indocyanine green (ICG) guided sentinel node (SN) mapping GC confirmed its technical feasibility, however no data exist regarding potential pathological nodal staging. To best our knowledge, current study is first to...