A5080153262- Enzyme Production and Characterization
- Infections and bacterial resistance
- Microbial metabolism and enzyme function
- Polysaccharides and Plant Cell Walls
- Polysaccharides Composition and Applications
- Microbial bioremediation and biosurfactants
- Trace Elements in Health
- Chromium effects and bioremediation
- Phytase and its Applications
- Crystallography and molecular interactions
- Pomegranate: compositions and health benefits
- Plant responses to water stress
- Cellular transport and secretion
- Catalytic C–H Functionalization Methods
- Bacterial Genetics and Biotechnology
- HIV Research and Treatment
- Molecular Spectroscopy and Structure
- Medicinal plant effects and applications
- Microbial Applications in Construction Materials
- Monoclonal and Polyclonal Antibodies Research
- Environmental Chemistry and Analysis
- Chemical Synthesis and Analysis
- Electrochemical Analysis and Applications
- Biochemical effects in animals
- Plant Micronutrient Interactions and Effects
National Institute of Science Education and Research
2015-2025
Homi Bhabha National Institute
2017-2024
Lehigh University
2017
Careful protein structure analysis unravels many unknown and unappreciated noncovalent interactions that control structure; one such unrecognized interaction in is selenium centered hydrogen bonds (SeCHBs). We report, for the first time, SeCHBs involving amide proton of selenomethionine (Mse), i.e., amide–N–H···Se H-bonds discerned proteins. Using mass selective conformer specific high resolution vibrational spectroscopy, gold standard quantum chemical calculations at CCSD(T), in-depth...
ZraS is a metal sensor integral to ZraPSR, two-component signaling system found in enterobacters. It belongs family of bifunctional histidine kinases (SHKs) and speculated sense zinc-induced stress on the bacterial envelope. Information structure-function relationship elusive due lack full-length structures, intrinsically dynamic behavior, difficulty trapping them active state conformations. While kinase domains (KDs) few SHKs are well characterized, they exhibit significant functional...
Polysaccharide lyases (PLs) are a broad class of microbial enzymes that degrade anionic polysaccharides. Equally diversity in their polysaccharide substrates has attracted interest biotechnological applications such as biomass conversion to value-added chemicals and biofilm removal. Unlike other PLs, Smlt1473 present the clinically relevant Stenotrophomonas maltophilia strain K279a demonstrates wide range pH-dependent substrate specificities toward multiple, diverse polysaccharides:...
The present study demonstrates the removal of three toxic heavy metals (lead, cadmium and nickel) by bacterial strain Arthrobacter phenanthrenivorans from polluted water. efficiency was recorded to be highest in case lead (79.91%), followed nickel (47.62%) (34.05%). Furthermore, surfactant production A. optimized, which is useful for different purposes like metal oil Partial characterization semi-purified done thermal stability, pH tolerance ions sensitivity. Antioxidant enzyme activity...
Anionic polysaccharides found in nature are functionally and structurally diverse, so the polysaccharide lyases (PLs) that catalyze their degradation. Atomic superposition of various PL folds according to cleavable substrate structure confirms occurrence structural convergence at active sites. This suggests have emerged cleave a particular class anionic during course evolution. Whereas mechanistic similarity site has been highlighted earlier studies, detailed understanding regarding...
Abstract GABA (γ–amino butyric acid) analogues like baclofen, tolibut, phenibut, etc., are well–known B1 inhibitors and pharmaceutically important drugs. However, there is a huge demand for more chiral aryl with promising pharmacological actions. Here, we demonstrate the ligand acetyl–protected amino quinoline (APAQ) mediated enantioselective synthesis of inhibitor drug scaffolds from easily accessible via Pd–catalyzed C(sp 3 )−H activation. The synthetic methodology shows moderate to good...
ZraS is a metal sensor integral to ZraPSR, two-component signaling system found in enterobacters. It belongs family of bifunctional histidine kinases (SHKs) and speculated sense zinc-induced stress on the bacterial envelope. Information structure-function relationship elusive due lack full-length structures, intrinsically dynamic behavior, difficulty trapping them active state conformations. While kinase domains few are well-characterized, they exhibit significant functional diversity...
Biotin protein ligase catalyses the post-translational modification of biotin carboxyl carrier (BCCP) domains, a that is crucial for function several carboxylases. It two-step process results in covalent attachment to ɛ-amino group conserved lysine BCCP domain carboxylase an ATP-dependent manner. In Leishmania , three mitochondrial enzymes, acetyl-CoA carboxylase, methylcrotonyl-CoA and propionyl-CoA depend on biotinylation activity. view indispensable role biotinylating enzyme activation...
Polysaccharide lyases (PLs) are group of enzyme that cleaves diverse array anionic polysaccharides via lytic β-elimination reaction mechanism.The end product is generated as an unsaturated hexenuronic acid at newly formed non-reducing end, with a concomitant cleavage glycosidic bond.Depending upon the fold adopted by secondary structure elements, which range from α/α barrels to β-helices, PLs classified into 24 different classes (PL-1 PL-24).PLs have been reported catalyze degradation...
Abstract Anionic polysaccharides found in nature are functionally and structurally diverse, so the polysaccharide lyases (PLs) which catalyse their degradation. Atomic superposition of various PL folds according to cleavable substrate structure confirm occurrence structural convergence at active sites. This suggests that have emerged cleave a particular class anionic during course evolution. While mechanistic similarity PLs site been highlighted earlier studies, detailed understanding...