A5020774183- Nanoplatforms for cancer theranostics
- Inflammatory Bowel Disease
- Microscopic Colitis
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Esophagitis
- Intestinal Malrotation and Obstruction Disorders
- Clostridium difficile and Clostridium perfringens research
- Infectious Disease Case Reports and Treatments
- Advanced Nanomaterials in Catalysis
- Pancreatitis Pathology and Treatment
- Photodynamic Therapy Research Studies
- Helicobacter pylori-related gastroenterology studies
- Diverticular Disease and Complications
- Gastrointestinal disorders and treatments
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Inflammatory mediators and NSAID effects
- Pancreatic and Hepatic Oncology Research
- Gastroesophageal reflux and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Autoimmune and Inflammatory Disorders Research
- Gallbladder and Bile Duct Disorders
- Esophageal and GI Pathology
- Pediatric Urology and Nephrology Studies
- Viral gastroenteritis research and epidemiology
The University of Texas Southwestern Medical Center
2019-2025
Children's Medical Center
2019-2025
Shenzhen University
2021-2024
FHNW University of Applied Sciences and Arts
2024
Yashoda Hospital
2023
Cancer Institute (WIA)
2023
Shenzhen University Health Science Center
2020-2022
Southwestern Medical Center
2019-2022
Medical City Children's Hospital
2020-2021
Dalian University
2018-2020
Paneth cell dysfunction has been implicated in a subset of Crohn's disease (CD) patients. We previously stratified clinical outcomes CD patients by using phenotypes, which we defined the intracellular distribution antimicrobial proteins. Animal studies suggest that cells shape intestinal microbiome. However, it is unclear whether phenotypes alter microbiome complexity subjects. Therefore, analyzed correlation with mucosal composition and ileal RNA expression pediatric noninflammatory bowel...
Cyclooxygenase-2 (COX-2) is an enzyme overexpressed in most types of cancers and has been used for excellent targetable biomarker. Celecoxib effective inhibitor COX-2, anti-inflammation. Herein we report a one two-photon fluorescence probe (NP-C6-CXB) based on the conjugation naphthalamide with Celecoxib, by using flexible hexylene linker. NP-C6-CXB nonfluorescent buffer solution normal cells, while it shows bright solutions cancer cells presence COX-2 selectivity. Interestingly, can...
NIR alkylated cationic photosensitizers targeting at lyso-membrane for eradicating tumor cells through prominent superoxide radical generation (type-I PDT) <italic>via</italic> lysosome disruption pathway.
Children with inflammatory bowel disease [IBD] are disproportionally affected by recurrent Clostridioides difficile infection [rCDI]. Although faecal microbiota transplantation [FMT] has been used good efficacy in adults IBD, little is known about outcomes associated FMT paediatric IBD.We performed a retrospective review of at 20 centres the USA from March 2012 to 2020. and without IBD were compared determined differences for rCDI. In addition, children successful outcome predictors success....
Benefiting from its strong cytotoxic features, singlet oxygen (1O2) has garnered considerable research attention in photodynamic therapy (PDT) and thus, plenty of inorganic PDT agents have been recently developed. However, consisting metal/semiconductor hybrids are surprisingly rare, bearing very low 1O2 quantum yield, their vivo applications remain elusive. Herein, we provide an unprecedented report that the Au/MoS2 hybrid under plasmon resonant excitation can sensitize generation with a...
ABSTRACT Background: Post‐endoscopic retrograde cholangiopancreatography (post‐ERCP) pancreatitis (PEP) is reported to occur in up 11% of pediatric patients. To date, no study has prospectively evaluated an intervention prevent PEP children. It unclear if such a even feasible. Objective: The aim the was evaluate feasibility studying IV ibuprofen for prevention population. Methods: This prospective randomized double‐blind placebo‐controlled study. Patients younger than 19 years age undergoing...
Abstract Endogenous stimuli‐responsive prodrugs, due to their disease lesion specificity and reduced systemic toxicity, have been widely explored for antitumor therapy. However, reactive oxygen species (ROS) as classical endogenous stimuli in the tumor microenvironment (TME) are not enough achieve expected drug release. Herein, a ROS‐activatable heterodimeric prodrug‐loaded enzyme assembly is developed self‐boosting programmable release of multiple therapeutic agents. The prodrug NBS‐TK‐PTX...
Cancer phototheranostics in second biological window (1000–1500 nm) has recently emerged as a promising alternative of first because high light penetration depth, minimal tissue absorption, reduced scattering, better resolution, less autofluorescence, and signal to noise ratio. With the rapid progress chemical biology, nanomedicine, material science, multifunctional inorganic with broadband absorption (1000–1350 near-infrared-II (NIR-II) biowindow been actively developed diagnose treat...
The inflammatory state associated with Crohn's disease (CD) and ulcerative colitis (UC) remains incompletely defined. To understand more clearly the extracellular milieu bowel (IBD), we employed a bioassay whereby plasma of treatment naive paediatric IBD patients (n = 22 CD, n 15 UC) unrelated healthy controls (uHC, 10) were used to induce transcriptional responses in leucocyte population. After culture, gene expression was measured comprehensively microarrays analysed. Relative uHC, CD UC...
Gold nanorods (GNRs) with a unique localized surface plasmon resonance (LSPR) property have shown groundbreaking performance in catalysis, sensing, and biomedical applications. Intrinsic inertness, biocompatibility, tunable longitudinal LSPR band the near‐infrared (NIR)‐I/II region, high extinction coefficient, remarkable optical properties all make GNRs excellent photothermal (PT) nanoagents, photosensitizers, imaging contrast agents for drug delivery, cancer phototherapy, multimodal...
Abstract Background Inflammatory bowel disease is an inflammatory disorder that primarily impacts the gastrointestinal tract, leading to malnutrition and chronic microscopic intestinal blood loss. Uncontrolled systemic inflammation can impact other parts of body, known as extraintestinal manifestations. Up 25% patients with are reported have these complications in their skin, joints, bones, eyes, liver, lung, pancreas (Rogler et al. Gastroenterology 161(4):1118–1132, 2021). Neurologic...
<ns4:p>The landscape of pediatric inflammatory bowel disease is rapidly evolving. The therapeutic advances seen in the adult arena are being adopted by gastroenterologists and evaluated both controlled trials real-world experience. Though anti-tumor necrosis factor agents have been primary therapy over last decade, recently there has an expansion targets alternative mechanism action drugs with a focus on individualized personalized therapy. By reviewing epidemiology, pathophysiology, goals...
<ns3:p><ns3:bold>Background: </ns3:bold>Ustekinumab is a monoclonal antibody that inhibits interleukins 12 and 23. It approved for treatment of Crohn’s disease (CD) in adults; however, there paucity data regarding its use pediatric CD. We describe our experience using ustekinumab anti-TNF refractory CD patients.</ns3:p><ns3:p> <ns3:bold>Methods: </ns3:bold>We performed retrospective chart review on patients with who were started from January 2016 to November 2018. collected patient’s...
Esophagitis dissecans superficialis (EDS) is a desquamative disorder of the superficial esophageal epithelium with variable clinical characteristics. Endoscopically, there an appearance peeling sheets epithelium. Histologically 2-toned coagulative necrosis Currently, paucity data regarding this condition in children.A 10-year retrospective search pathology information system was performed for cases pathologic diagnosis EDS tertiary care pediatric center. Demographic data, history, endoscopic...