A5018855499- Medicinal plant effects and applications
- Ferroptosis and cancer prognosis
- Endoplasmic Reticulum Stress and Disease
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Fungal Biology and Applications
- Pharmacological Effects of Natural Compounds
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Bioactive Compounds and Antitumor Agents
- PARP inhibition in cancer therapy
- Silymarin and Mushroom Poisoning
- Sirtuins and Resveratrol in Medicine
- MicroRNA in disease regulation
- Bioactive natural compounds
- Gout, Hyperuricemia, Uric Acid
- FOXO transcription factor regulation
- Heat shock proteins research
Guangdong Pharmaceutical University
2024-2025
Wenzhou Medical University
2021-2025
Naval University of Engineering
2025
Hebei North University
2020
Phellinus igniarius is an important medicinal and edible fungus with diverse biological activities. This study aimed to investigate the effects of aqueous extract from P. (API) on treatment hyperuricemia (HUA) related kidney damage. The chemical constituents API were determined. therapeutic HUA renal injury assessed in adenine/potassium oxonate (PO)-treated mice. constituent analysis revealed a predominance polysaccharides (33.4 %), followed by total flavonoids (9.1 triterpenoids (3.5 %)....
Radiotherapy has been used for decades in the treatment of liver cancer. We previously found that adiponectin receptor (AdipoR1) is a prognostic biomarker hepatoma carcinoma (HCC) after stereotactic body radiation therapy (SBRT) and blocking AdipoR1 enhances sensitivity cells. In current study, we aimed to elucidate roles ionizing radiation- (IR-) induced radiosensitivity by activating ferroptosis pathway HCC IR upregulated expression furthermore promoted protein stability transcription...
Abstract Hepatocellular carcinoma is one of the most common malignant tumors, and radiotherapy plays a pivotal role in its therapeutic regimen. However, resistance main cause failure patients. Our previous study revealed that Adiponectin Receptor 1 (AdipoR1) involved regulating radiation liver cancer patients treated with stereotactic body radiotherapy. To explore mechanism, we performed high-throughput transcriptome sequencing hepatocellular cells stable knockdown AdipoR1. KEGG enrichment...
Resveratrol has been extensively studied as the anti-cancer agent. A variety of resveratrol analogues have developed with structural modification to improve its bioactivity. In this work, analogues, compound 1-4, were designed and synthesized Stille-Heck reaction. These results showed 1-4 had better anticancer effect than that parent resveratrol. Especially 1 ((E)-4,4'-(ethene-1,2-diyl)bis(3-methylphenol)) displayed excellent cytotoxicity high selectivity. The mechanism research indicated...
Abstract Background: Ferroptosis is a type of cell death accompanied by iron-dependent lipid peroxidation, however, how IR-induced ferroptosis regulated in Hepatocellular carcinoma cells (HCC) remains largely unknown. We have previously found that adiponectin receptor 1(AdipoR1) might be prognostic biomarker for HCC after stereotactic body radiotherapy (SBRT). In this study, we aimed to elucidate the roles AdipoR1 radiation-induced HCC. Methods: Human line MHCC-97H and HepG2 human hepatic...