A5089050393- Anesthesia and Sedative Agents
- Nausea and vomiting management
- Anesthesia and Pain Management
- Blood transfusion and management
- Venous Thromboembolism Diagnosis and Management
- Metabolism and Genetic Disorders
- Organ Transplantation Techniques and Outcomes
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal Respiratory Health Research
- Liver Disease and Transplantation
- Platelet Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Mechanical Circulatory Support Devices
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Robotics and Automated Systems
- Hemodynamic Monitoring and Therapy
- Polymer composites and self-healing
- Transplantation: Methods and Outcomes
- Cancer Treatment and Pharmacology
- Heparin-Induced Thrombocytopenia and Thrombosis
- Vagus Nerve Stimulation Research
- Organ Donation and Transplantation
- Erythrocyte Function and Pathophysiology
- Pain Management and Opioid Use
Kyoto University Hospital
2015-2024
Kyushu University
2016
Nagahama City Hospital
2011
Abstract Background Remimazolam is an intravenous ultra-short-acting benzodiazepine with the benefit of hemodynamic stability, including blood pressure and pulse rate. We report a case in which remimazolam was used living donor liver transplantation stable hemodynamics. Case presentation A 19-year-old woman underwent due to end-stage disease, associated hyperdynamic state instability. The patient’s sister had history malignant hyperthermia, so we chose total anesthesia remimazolam....
Abstract Background There is no standardized storage temperature of whole blood for acute normovolemic hemodilution (ANH). Study Design and Methods We conducted a prospective observational study to examine the difference in platelet function between short‐term at 4 22°C. Venous (40 ml) was collected from seven healthy subjects who gave prior written consent. The samples were divided into three groups: before (group Pre), cold (4°C) C), room (22°C) R). Groups C R tested after 6 h storage....
In liver transplantation for end-stage failure, monitoring of continuous cardiac output (CCO) is used circulatory management due to hemodynamic instability. CCO often measured using the minimally invasive FloTrac/Vigileo system (FVS-CCO), instead a highly pulmonary artery catheter (PAC-CCO). The FVS has improved accuracy an updated algorithm, but effect this change on FVS-CCO in unclear. study, we assessed agreement between fourth-generation and PAC-CCO 20 patients aged ≥ years who underwent...
Rocuronium is an aminosteroid nondepolarizing neuromuscular blocker that widely used for anesthesia and intensive care. In this study, we investigated the effect of rocuronium on human platelet functions in vitro. The effects aggregation, P-selectin expression, cyclic adenosine monophosphate (cAMP) levels platelets were measured using aggregometer, enzyme immunoassay, flow cytometry, respectively. inhibited ADP-induced expression suppression cAMP production. These not antagonized by...
Abstract Background Heparin-induced thrombocytopenia type II (HIT II) is a rare, immune-mediated complication of heparin therapy and can cause life-threatening thromboembolism. However, perioperative anticoagulation for patients with HIT has not been established. Case presentation A 6-year-old boy tetralogy Fallot underwent radical intracardiac repair administration argatroban at 1 year old due to positive antibody. Reoperation was scheduled pulmonary valve insufficiency, using nafamostat...
Methylmalonic acidemia (MMAemia) is a rare hereditary disease affecting organic acid metabolism. It causes recurrent metabolic acidosis and secondary mitochondrial dysfunction, resulting in poor prognosis. Liver transplantation (LT) has been performed to facilitate the metabolism of acids improve prognosis MMAemia. However, there have few reports on perioperative management LT. A 22-month-old female with severe MMAemia was scheduled receive LT relieve despite dietary pharmacological...
Abstract Acute normovolemic hemodilution (ANH) is a potential transfusion method for platelets, as well red blood cells. However, previous studies have shown that whole storage in ANH decreases platelet aggregability by 14.7–76.3% and this decrease not recovered reinfusion. We investigated whether new 6 h using polyolefin bag, based on the concentrates method, would maintain function better than conventional polyvinyl chloride bag. demonstrated of bag maintained ADP-induced aggregation rates...
【目的】当院は、生活習慣病の予防・改善、ロコモティブシンドローム予防を目的として運動教室開設準備を進めている。目的に即していて、かつ効果が上がる教室とするにはどのような運動が適切かを検討するためにこの研究を行った。【対象並びに方法】対象は、2012年10月1日から2016年7月31日までに、当センターにおいて特定健診の検査項目を満たす健診を受診して、特定健康診査の標準的な質問票が記入された13,697人(男性7,860人、女性5,837人)である。【方法】質問項目の「1回30分以上の軽く汗をかく運動を週2日以上、1年以上実施している」と記されている運動習慣に関する質問、および「日常生活において歩行又は同等の身体活動を1日1時間以上実施している」の各々に対する回答、「①はい」、「②いいえ」の2群について、特定健診で採用されている身体計測値(腹囲、BMI、収縮期血圧、拡張期血圧)および血液検査値(グルコース、HbA1c、ALT、AST、γ-GTP、LDL-C、HDL-C、中性脂肪)値の平均±SDを算出して「はい」、「いいえ」2群間の差をt-testにて検定した。【結果】身体計測値:質...
Abstract Background The IMPELLA® is a minimally invasive left ventricular assist device. We report case in which transesophageal echocardiography (TEE) was useful diagnosis of rupture after insertion. Case presentation A 75-year-old man presented to the emergency room with chest pain and underwent percutaneous coronary intervention for 100% stenosis anterior descending branch #7. An inserted stabilize circulation, but hypotension persisted. Transthoracic revealed increased pericardial...
Background: Dexmedetomidine (DEX) is a potent and highly selective agonist of the α2-adrenoceptor.Recent studies suggested that platelet-derived microparticles (PMPs) have procoagulant activity was released from activated platelet membranes might be involved in thrombogenesis.In present study, we examined effects DEX on PMP generation human platelets by flow cytometry.Methods: Platelet rich plasma prepared healthy male volunteers who had not taken any medication for at least two weeks before...
Effects of rocuronium and sugammadex on human platelet functions in vitroSG forms tight complexes at a 1:1 ratio with RN by encapsulating.Our results demonstrate that RN-SG complex suppressed within the usual therapeutic concentration range (< 10 g/ml).Therefore, it might be possible affect clinical setting.SG does not completely encapsulate RN.Morpholine ring molecule is outside SG known to have suppressive effect P2Y12 receptor blocking.Therefore, Morpholine may contribute this effect.
当地区においては2019年から対策型の胃がん検診に内視鏡検査が取り入れられる予定となった。今後内視鏡検査が増えることが想定され、これまで行ってきた内視鏡検診の実績をまとめ、今後の対応について検討した。
In our previous study for healthy volunteers, DEX (100 ng/ml) enhanced PS expression, and PRO (40 μM) (>70μM) suppressed platelet aggregation, which supports the results of this study.・It is reported that stabilizes initial aggregates in human platelets vitro, contributes to increase stabilization arterial thrombi.・In order confirm whether enhancing effect on functions postoperative period, perioperative time-course expression must be examined.・Moreover, vivo studies are needed clarify...
Background:Few reports are available on anesthetic management of liver transplantation (LT) for methylmalonic acidemia (MMAemia) [1] , although LT has been performed as a supportive therapy severe MMAemia to improve the prognosis.Here, we show successful perioperative patient receiving LDLT.Case presentation: 22-month-old girl (70cm, 9.9kg) with was admitted our hospital have living donor from her mother.
Background: Kartagener syndrome (KS) is a partial disease of primary ciliary dyskinesia with defects in the fine structure cilia and flagella. KS an autosomal recessive inherited three major features: visceral inversion, chronic sinusitis, bronchiectasis. Lung transplantation option for end-stage KS, which results in respiratory insufficiency. However, there have been few reports on perioperative management lung transplantation patients KS. Case presentation: A 44-year-old female...
Jacobsen syndrome is a rare genetic disorder with multiple congenital anomalies and platelet abnormalities caused by chromosome 11 deletion.A 7-month-old boy thrombocytopenia underwent ventricular septal defect closure. At the beginning of surgery, count was 168 × 103/μL, heparinized kaolin heparinase reaction time (HKH-R), which represents clot formation time, prolonged at 30.4 min. Platelet transfusion continued, end HKH-R values improved to 215 103/μL 15 min, respectively.As anesthetic...