A5031123738- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Electrolyte and hormonal disorders
- Statistical Methods in Clinical Trials
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
- Mechanical Circulatory Support Devices
- Potassium and Related Disorders
- Pain Management and Opioid Use
- Sodium Intake and Health
- Child and Adolescent Health
- Diabetes Treatment and Management
- Pharmacological Effects and Toxicity Studies
- Dialysis and Renal Disease Management
- Opioid Use Disorder Treatment
- Advanced Causal Inference Techniques
- COVID-19 Clinical Research Studies
- Thyroid Disorders and Treatments
- Fetal and Pediatric Neurological Disorders
- Diabetes Management and Education
- Family and Patient Care in Intensive Care Units
- Diabetes Management and Research
- Obesity and Health Practices
- Hypothalamic control of reproductive hormones
- Frailty in Older Adults
University of Alberta
2019-2025
Canadian VIGOUR Centre
2021-2025
Women and Children’s Health Research Institute
2021-2024
Alberta Hospital Edmonton
2022
University of Calgary
2021
<h3>Background:</h3> Identification of therapies to prevent severe COVID-19 remains a priority. We sought determine whether hydroxychloroquine treatment for outpatients with SARS-CoV-2 infection could hospitalization, mechanical ventilation or death. <h3>Methods:</h3> This randomized controlled trial was conducted in Alberta during the first wave pandemic without direct contact participants. Community-dwelling individuals confirmed (by reverse transcription polymerase chain reaction [RT-PCR]...
Abstract Background Randomized controlled clinical trials remain the gold standard for determining efficacy of new heart failure (HF) therapies; however, to account heterogeneity in risk primary endpoint(s) may dilute treatment efficacy. The novel 5-step stratified testing and amalgamation routine (5-STAR) methodology addresses these limitations using stratification based on treatment-independent associations between baseline covariates outcomes. We applied 5-STAR original VICTORIA database...
Background: Puberty suppression is a standard of care for gender-affirming therapy in gender-diverse youth. Leuprolide acetate gonadotropin-releasing hormone agonist (GnRHa) commonly used pubertal suppression. There are concerns that GnRHa agents prolong the rate-corrected QT interval (QTc) when as androgen deprivation management prostate cancer; however, there paucity literature regarding effect leuprolide on QTc intervals Aim: To determine proportion youth with prolongation therapy....
Prognostic tools with evidence for external validity in routine clinical practice are needed to align care patients' preferences and deliver timely supportive services. Current models have limited, if any, none been implemented evaluated on a large scale. This study sought provide real life setting of the Cohen prognostic model that integrates actuarial factors 'Surprise Question' assess 6-month, 12-month 18-month survival prevalent haemodialysis patients. Cross-sectional 1372 patients...
Abstract Background Composite endpoints for estimating treatment efficacy are routinely used in several therapeutic areas and have become complex the number types of component outcomes included. It is assumed that its components similar asperity chronology between both arms as well uniform magnitude effect. However, these assumptions rarely satisfied. Understanding this heterogeneity important developing a meaningful assessment Methods We developed Weighted Endpoint (WCE) method which uses...
Abstract Aims N‐terminal pro‐b‐type natriuretic peptide (NT‐proBNP) values may be influenced by patient factors beyond the severity of illness, including atrial fibrillation (AF), renal dysfunction, or increased body mass index (BMI). We hypothesized that these influence achievement NT‐proBNP targets and clinical outcomes. Methods A total 894 patients with heart failure reduced ejection fraction were enrolled in The Guiding Evidence‐Based Therapy Using Biomarker Intensified Treatment trial....
It is recommended that primary care-based physicians refer children with overweight and obesity to multidisciplinary paediatric management, which can help improve weight health.To determine predictors of referral management.This retrospective, population-level study included who could 2-17 years old a body mass index ≥85th percentile one three management clinics in Alberta, Canada. Physician demographic procedural data were obtained from Practitioner Claims Provider Registry maintained by...
The introduction of next generation sequencing (NGS) technologies has revolutionized the practice Medical Genetics, and despite initial reticence in its application to prenatal genetics (PG), it is becoming gradually routine, subject availability. Guidance for clinical implementation NGS PG, particular whole exome (ES), been provided by several professional societies with multiple studies quoting a wide range testing yields. ES was introduced our tertiary care center 2017; however, use...
To describe and compare caregiver perceptions of their emergency department (ED) experiences with without child life specialist (CLS) involvement in child's overall care. A descriptive cross-sectional survey caregivers children 0-17 years at a tertiary care pediatric ED was completed from March to August 2021. Survey themes included perceived experience satisfaction, impact specialists. total 179 the survey; mean age 38.9 (SD 8.4), 72.6% (122/179) were mothers. Caregivers CLS (CLS+) ranked...
In heart failure (HF) trials, there has been an emphasis on utilizing more patient-centered outcomes, including quality of life (QoL) and days alive out hospital. We aimed to explore the impact QoL adjusted hospital as outcome in 2 HF clinical trials.
The effectiveness of newborn screening (NBS) for congenital hypothyroidism (CH) relies on timely screening, confirmation diagnosis, and initiation ongoing monitoring treatment. objective this study was to ascertain the extent which infants with CH have received appropriate management within first 3 years life, following diagnosis through NBS in Alberta, Canada. Deidentified laboratory data were extracted between 1 April 2014 31 March 2019 from Alberta Health administrative databases born...
SODIUM-HF was a large clinical trial testing dietary sodium restriction compared to usual care in patients with heart failure that showed no reduction events. It has been suggested diuretic doses response modification may have influenced the results.
Background: In the VICTORIA trial in patients with heart failure reduced ejection fraction, vericiguat (V) versus placebo (P) primary composite outcome (heart hospitalization [HFH] or cardiovascular death [CVD]) from 38.5 to 35.5% (1869 events: V=897, P=972) ( Fig A ). this prespecified analysis, we assessed vericiguat’s treatment effect using weighted endpoint (WCEP) and win-ratio (WR) methods. Methods: Clinical events were centrally adjudicated. survey of 37 international leaders conducted...