Haemorrhage remains the leading cause of potentially survivable death in both military and civilian populations. Although a large variety hemostatic agents have been developed, many them an inadequate capacity to induce hemostasis are not effective killing bacteria. In recent years, mesoporous bioactive glasses (MBGs) were found be inducing hemostasis. However, materials may considered as ideal hemostats since they do offer antimicrobial activity. The gallium ion (Ga+3) only exhibits...

Chitosan-based hemostats are promising candidates for immediate hemorrhage control. However, they have some disadvantages and require further improvement to achieve the desired hemostatic efficiency. Here, a series of 1% Ga2O3-containing mesoporous bioactive glass–chitosan composite scaffolds (Ga-MBG/CHT) were constructed by lyophilization process effect various concentrations Ga-MBG (10, 30, 50 wt %) on function CHT scaffold was assessed as compared that Celox Rapid gauze (CXR), current...

Treatment of chondral injuries remains a major issue despite the many advances made in cartilage repair techniques. Although it has been postulated that use marrow stimulation combination with cell-based therapy may provide superior outcome, this yet to be demonstrated. A pilot study was thus conducted determine if bone derived mesenchymal stromal cells (BM-MSCs) have modulatory effects on outcomes (BMS) Two full-thickness 5 mm diameter defects were created tandem medial condyle left stifle...

A comparative study on the in vitro osteogenic potential of electrospun poly-L-lactide/hydroxyapatite/collagen (PLLA/HA/Col, PLLA/HA, and PLLA/Col) scaffolds was conducted. The morphology, chemical composition, surface roughness fibrous were examined. Furthermore, cell attachment, distribution, mineralization, extracellular matrix protein localization, gene expression human mesenchymal stromal cells (hMSCs) differentiated PLLA/Col/HA, PLLA/Col, PLLA/HA also analyzed. with a diameter 200–950...

Monosodium -iodoacetate (MIA)-induced animal model of osteoarthritis (OA) is under-utilised despite having many inherent advantages.At present, there lack studies that directly compare the degenerative changes induced by MIA with surgical induction method and human osteoarthritis, which would further verify a greater use this model.Therefore, we compared histological, biochemical biomechanical characteristics in rat using against anterior cruciate ligament transection (ACLT) cartilage...

Cerium oxide nanoparticles showed negligible local effects, low systemic toxicity and genotoxicity <italic>via</italic> implantation route.

Abstract Background In many pre-clinical studies of cartilage tissue, it has been generally assumed that the major difference tissue between species is thickness, which related to size animal itself. At present, there appear be lack demonstrating relationship chondrocyte densities, protein content, gene expressions and thickness in various models are commonly used. The present study was conducted determine whether or not density, proteoglycan/protein content selective expression merely (thus...

Objectives: To investigate the hemolytic potential of different types experimental cardiovascular stents [Bare Metal Stents (BMS), Sirolimus Eluting (SES), and Everolimus (EES)] in an vitro study using a bovine blood circulatory model. Methods : Fresh was circulated through loop containing stents, peristaltic pump for 6 hours at 37°C constant flow 200 mL/minute. Plasma Free Hemoglobin (PFH) measured spectrophotometrically defined intervals. The Normalized Index Hemolysis (NIH) Modified (MIH)...

Mesoporous bioactive glass containing 1% Ga2O3 (1%Ga-MBG) is attractive for hemorrhage control because of its surface chemistry which can promote blood-clotting. The present study compares this proprietary inorganic coagulation accelerator with two commercial hemostats, CeloxTM (CX) and QuikClot Advanced Clotting Sponge PlusTM (ACS+). results indicate that the number adherent platelets were higher on 1%Ga-MBG CX surfaces than ACS+ whereas a greater contact activation was seen CX. not only...

Previous studies have shown that platelet concentrates used in conjunction with appropriate growth media enhance osteogenic differentiation of human mesenchymal stromal cells (hMSCs). However, their potential inducing osteogenesis hMSCs when cultured serum free medium has not been explored. Furthermore, the resulting molecular signatures compared to standard medium. We studied effect infrequent supplementation (8-day interval) 15% non-activated platelet-rich concentrate (PRC) on...

Simultaneous saccharification and fermentation (SSF) of pre-treated lignocellulosics to biofuels other platform chemicals has long been a promising alternative separate hydrolysis processes. However, the disparity between optimum conditions (temperature, pH) for enzyme leads execution SSF process at sub-optimal conditions, which can affect rate cellulose conversion. The could be synchronized with optima by carrying out higher temperature, but this would require thermo-tolerant organism....

ABSTRACT In this investigation, terpolymers, copolymers, and homopolymer of acrylonitrile with dimethylaminopropyl acrylamide (DMAPA), itaconic acid (IA) viz., poly(acrylonitrile‐ran‐3‐dimethylaminopropyl acrylamide‐ran‐itaconic acid) [P(AN‐DMAPP‐IA)], poly(acrylonitrile‐ co ‐3, acrylamide) [P(AN‐DMAPP)] were synthesized varying amounts comonomers using solution polymerization process. The chemical structure, composition, bonding network determined employing infrared, 1H and, 13‐carbon...

Fracture healing in bone gap is one of the major challenges encountered Orthopedic Surgery. At present, treatment includes graft, employing either internal or external fixation which has a significant impact on patient, family and even society. New drugs are emerging markets such as anabolic bone-forming agents including teriparatide strontium ranelate to stimulate growth. Based mechanism their actions, we embarked study fractured ulna with rabbit model. We segregated ten rabbits into two...

Tissue engineering aims to generate or facilitate regrowth healing of damaged tissues by applying a combination biomaterials, cells, and bioactive signaling molecules. In this regard, growth factors clearly play important roles in regulating cellular fate. However, uncontrolled release has been demonstrated produce severe side effects on the surrounding tissues. study, poly(lactic-co-glycolic acid) (PLGA) microspheres (MS) incorporated three-dimensional (3D) CORAGRAF scaffolds were...

Abstract Stretchable self‐healing urethane‐based biomaterials have always been crucial for biomedical applications; however, the strength is main constraint of utilization these healable materials. Here, a series novel, healable, elastomeric, supramolecular polyester urethane nanocomposites poly(1,8‐octanediol citrate) and hexamethylene diisocyanate reinforced with cellulose nanocrystals (CNCs) are introduced. Nanocomposites various amounts CNCs from 10 to 50 wt% prepared using solvent...

The aim of the study was to evaluate serum lipid profile among untreated oral squamous cell carcinoma (OSCC) and submucous fibrosis (OSMF) patients.This done in three groups patients - OSMF, OSCC, control. There are twenty participants each group. Calorimetric method using semi-autoanalyzer used for analyzing levels (cholesterol, triglycerides [TGL], high-density lipids [HDL]) after collecting 2 ml fasting blood from these patients. Low-density [LDL] values were obtained by calculator...