A5036698603- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Mycology
- Neutropenia and Cancer Infections
- Hematopoietic Stem Cell Transplantation
- Oral health in cancer treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Mesenchymal stem cell research
- Mycobacterium research and diagnosis
- Fungal Biology and Applications
- Economic Development and Digital Transformation
- Cancer Treatment and Pharmacology
- Economic and Business Development Strategies
- Plant Pathogens and Fungal Diseases
- Transplantation: Methods and Outcomes
- Antimicrobial Resistance in Staphylococcus
- Congenital Diaphragmatic Hernia Studies
- Redox biology and oxidative stress
- Sulfur Compounds in Biology
- Renal Transplantation Outcomes and Treatments
- Burn Injury Management and Outcomes
- Economic and Technological Developments in Russia
- Organ and Tissue Transplantation Research
First Pavlov State Medical University of St. Petersburg
2014-2025
Maine Farmland Trust
2017
<p>The article concerns our experience of psychological assistance for the sibling donors in course hematopoietic stem cell transplantation (HSCT) procedure. We discuss support a case 6-year old girl with acute myeloid leukemia and her donor, 20-year brother. describe communications between clinical team, medical psychologist, patient&rsquo;s family, potential donor. The resulted into lower distress level observed donor cells, as well higher satisfaction making decision involvement...
Summary We prospectively observed 36 haematological patients with mucormycosis from nine hospitals of St. Petersburg during 2004–2013. The most frequent underlying diseases were acute leukaemia (64%), and main risk factors prolonged neutropenia (92%) lymphocytopenia (86%). In 50% the patients, was diagnosed 1–65 days after invasive aspergillosis. Main clinical form pulmonary while two or more organ involvement noted in cases. aetiological agents Rhizopus spp. (48%). Twelve‐week survival rate...
In 2004–2016 we prospectively observed 59 oncohematology patients with mucormycosis; 21 children and 38 adults. The most frequent underlying diseases were acute myeloid leukemia lymphoblastic (64 %); main risk factors с ytostatic chemotherapy allogeneic HSCT prolonged (median – 30 days) neutropenia lymphocytopenia. etiology agents Rhizopus spp. (47 Rhizomucor (28 Lichtheimia corу mbifera (17 %) Mucor (8 %). was found more often in children; Pulmonary mucormycosis clinical form (73 ≥2 organs...
The aim of the study was to investigate a role different antioxidant enzymes for tracheal epithelium regeneration after chemical burn. Methods. conducted in rat model burn upper airways caused by inhaled hydrochloric acid. Results. According results histological examination, 2nd day exposure approximately 70 % epithelial surface remained injured, mostly due death ciliated cells. degree damage unchanged 4th exposure. Visible began 7th day. cells generally necrosis though cell apoptosis also...
Background. Despite of modern methods diagnosing, prevention and treatment, invasive fungal disease (IFD) remains actual problem after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Data IFD in adolescents young adults (15–25 y.o.) allo-HSCT are limited. The aim the study was to estimate incidence, etiology, clinical signs outcome recipients allo-HSCT. Materials methods. In retrospective single center from Jan 2013 Dec 2014 were included 80 pts first clinic of Raisa...
Abstract Background Pediatric palliative care (PPC) is a priority to improve pediatric hematology oncology (PHO) in Eurasia. However, there are limited regional opportunities for PPC education. We describe the adaptation and implementation of bilingual end‐user Education Palliative End‐of‐Life Care (EPEC)‐Pediatrics course PHO clinicians Methods Due COVID‐19, this was delivered virtually, consisting prerecorded, asynchronous lectures, workshop with interactive lectures small group sessions....
In the retrospective multicenter study during 2007–2017 we included 59 oncohematological patients with mucormycosis and 541 invasive aspergillosis. Our showed that mucomorhycosis more often developed in children adolescents (p = 0.001), after «graft versus host» disease development 0.0001). Patients were immunosuppressed: severe neutropenia was 88 % vs. 82 %, median duration of ‒ 30 days 14 days, p 0.0001, lymphocytopenia – 77 65 25 0.001. The main sites infection lungs, nevertheless it less...
We present the results of a multicenter study 445 patients with “proven” and “probable” invasive aspergillosis (EORTC/MSG, 2008). Invasive aspergillosis usually occurs in hematological malignancies (88 %), main underlying diseases were acute myeloid acute lymphoblastic leukemia. The risk factors: prolonged agranulocytosis (64 cytostatic chemotherapy (57 corticosteroid treatment (45 %), and allogeneic hematopoietic stem cells transplantation (29 %). pathogens – A. fumigatus (42 niger (33...
We have evaluated the safety and efficiency of comprehensive examination bronchoalveolar lavage (BAL) (n = 222) for diagnosis invasive aspergillosis lungs (IAL) at 150 patients after hematopoietic stem cell transplantation (HSCT) in childhood. There were no major adverse effects during bronchoscopy. IAL was revealed 30 % HSCT recipients with changes computer tomogram. The multivariant analysis galactomannan (GM) test showed higher sensitivity indices comparison direct microscopy inoculation...
Bronchiolitis obliterans (BO) is a severe form of chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Aim. The aim current study was to evaluate the incidence, risk factors, and clinical manifestation BO allo-HSCT. Methods. included 1189 adult patients who received allo-HSCT at R.M.Gorbacheva Research Institute Pediatric Oncology, Hematology Transplantation, Academician I.P.Pavlov First Federal Saint-Petersburg State Medical...
Objective. Data analysis of the register patients with invasive aspergillosis (IA), which was founded in Saint Petersburg (1998–2017), and clinical case description successful treatment IA mucormycosis lungs involvement a patient Hodgkin’s lymphoma. Materials methods. In study were included 29 oncohematological mucormycosis. control group 483 IA. We used criteria EORTS/MSG, 2008 for diagnosis. Results. identified that combination significantly often develops acute lymphoblastic leukemia (32...
Цель - изучение регенерации респираторного эпителия крысы при ингаляционной травме трахеи парами соляной кислоты. Методика. Активация процессов проводилась после химического ожога путем аппликации в трахею кондиционированной среды, полученной культивировании аллогенных мезенхимальных стволовых клеток (кМСК). Результаты. Показано, что на 3-и 7-е сут. препарата кМСК эпителий практически полностью восстанавливается. При этом процессе подслизистом слое образуются замкнутые структуры, содержащие...
We observed 567 patients with invasive aspergillosis in 19 hospitals of St.-Petersburg from 1998 to 2012 years. It is known that a severe opportunistic infection high mortality. The most we children. analyzed the risk factors, etiology, basic clinical signs and treatment
Invasive fungal disease due to Candida spp. – candidiasis/candidaemia, is a life-threatening complication in immunosuppressed patients. The publications on epidemiology of invasive candidiasis (IC) children after hematopoietic stem cell transplantation (HSCT) limited. purpose the study was IC HSCT for 7 years Raisa Gorbacheva Memorial Research Institute Children Oncology, Hematology and Transplantation. In 2009–2016 yy have been performed 754 children: 494 allogeneic 260 autologous. approved...
Objective. To study risk factors, etiology, clinical signs and treatment outcomes of invasive aspergillosis (IA) mucormycosis combination (IAM) in children. Materials Methods. A retrospective review Saint-Petersburg register (1998–2021) patients with IA was done children IAM were included. EORTC/MSGERG 2019 criteria used for diagnosing results evaluation mycosis. We presented a case child acute lymphoblastic leukemia relapse. Results. total 12 They accounted 8% all pediatric (n = 152)....
155 children and adolescents who had been diagnosed oncohematological diseases undergone allogeneic hemapoetic stem cell transplantation were examined. In post-transplant period 80% of patients developed different bacterial complications. Main risk factors infections acute leukemia (73%), «graft versus host disease» (61%), severe infectious complications before HSCT (30%), cytomegaloviral reactivation (51%). causative agents Kl. pneumoniae (15%), Escherichia coli (8%), Enterobacter sp. (7%),...