A5079054362- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Bioinformatics and Genomic Networks
- Carbon Nanotubes in Composites
- Computational Drug Discovery Methods
- Microbial Metabolites in Food Biotechnology
- Experimental Learning in Engineering
- Engineering Education and Curriculum Development
- Polymer Nanocomposite Synthesis and Irradiation
- Phase Equilibria and Thermodynamics
- Engineering Education and Pedagogy
- Transition Metal Oxide Nanomaterials
- Electrostatics and Colloid Interactions
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Complex Network Analysis Techniques
- Botanical Research and Applications
- Carbon Dioxide Capture Technologies
- Diabetes Treatment and Management
- Wireless Body Area Networks
- Health disparities and outcomes
- Proteoglycans and glycosaminoglycans research
- Inflammasome and immune disorders
- Characterization and Applications of Magnetic Nanoparticles
- Advanced Physical and Chemical Molecular Interactions
Hacettepe University
2024
Yeditepe University
2009-2020
Rensselaer Polytechnic Institute
2011-2020
Boğaziçi University
2020
A fully closed-loop insulin-only system was developed to provide glucose control in patients with type 1 diabetes without requiring announcement of meals or activity. Our goal assess initial safety and efficacy this system.The multiple model probabilistic controller (MMPPC) anticipates when the patient is awake. The used subject's basal rates total daily insulin dose for initialization. tested at two sites on 10 a 30-h inpatient study, followed by 15 subjects three 54-h supervised hotel...
Initial Food and Drug Administration-approved artificial pancreas (AP) systems will be hybrid closed-loop that require prandial meal announcements not eliminate the burden of premeal insulin dosing. Multiple model probabilistic predictive control (MMPPC) is a fully system uses estimation meals to allow for automated detection. In this study, we describe safety performance MMPPC with announced unannounced in supervised hotel setting.The Android phone-based AP remote monitoring was tested 72 h...
Background: Continuous glucose monitors (CGMs) provide real-time interstitial concentrations that are essential for automated treatment of individuals with type 1 diabetes. Miscalibration, noise spikes, dropouts, or pressure applied to the site (e.g., lying on while sleeping) can cause inaccurate signals, which could lead inappropriate insulin dosing decisions. These studies focus problem pressure-induced sensor attenuations (PISAs) occur overnight and undesirable pump shut-offs in a...
OBJECTIVE As artificial pancreas (AP) becomes standard of care, consideration extended use insulin infusion sets (IIS) and continuous glucose monitors (CGMs) vital. We conducted an outpatient randomized crossover study to test the safety efficacy a zone model predictive control (zone-MPC)–based AP system versus sensor augmented pump (SAP) therapy in which IIS CGM failures were provoked via wear 7 21 days, respectively. RESEARCH DESIGN AND METHODS A smartphone-based was used by 19 adults...
Abstract: The structure and properties of nanocomposites poly(ethylene oxide), with Ag Au nanoparticles, surface modified a 1:1 (by volume) oleylamine/oleic acid mixture, were investigated via transmission electron microscopy, scanning thermogravimetric analysis, differential calorimetry (DSC), infrared spectroscopy, dynamic mechanical static testing. Results indicated that there was more oleylamine on nanoparticles but oleic nanoparticles. This difference in surfactant populations each...
Closed-loop control (CLC) for the management of type 1 diabetes (T1D) is a novel method optimizing glucose control, and strategies individualized implementation are being developed. To analyze glycemic in an overnight CLC system designed to "reset" patient near-normal targets every morning. Randomized, crossover, multicenter clinical trial. Forty-four subjects with T1D requiring insulin pump therapy. Sensor-augmented therapy (SAP) at home vs 5 nights (active from 23:00 07:00) supervised...
Background: As evidence emerges that artificial pancreas systems improve clinical outcomes for patients with type 1 diabetes, the burden of this disease will hopefully begin to be alleviated many and caregivers. However, reliance on automated insulin delivery potentially means slower act when devices stop functioning appropriately. One such scenario involves an infusion site failure, where is recorded as delivered fails affect patient’s glucose expected. Alerting these events in real time...
Reliable continuous glucose monitoring (CGM) enables a variety of advanced technology for the treatment type 1 diabetes. In addition to artificial pancreas algorithms that use CGM automate subcutaneous insulin infusion (CSII), can also inform fault detection alert patients problems in or CSII. Losses set actuation (LISAs) adversely affect clinical outcomes, resulting hyperglycemia due impaired delivery. Prolonged may lead diabetic ketoacidosis-a serious metabolic complication Therefore, an...
Continuous subcutaneous insulin infusion pumps and continuous glucose monitors enable individuals with type 1 diabetes to achieve tighter blood control, are critical components in a closed-loop artificial pancreas. Insulin sets can fail CGM sensor signals suffer from variety of anomalies. In this paper algorithms developed detect set failures signal anomalies; both in-patient out-patient studies presented. A threshold-based method, based on high concentrations, is shown be adequate failures....
There is accumulating evidence that the proteins encoded by genes associated with a common disorder interact each other, participate in similar pathways and share GO terms. It has been anticipated functional modules disease related linkage network can be integrated bibliomics to reveal association other complex disorders. In this study, cardiovascular (CFN) containing 1536 nodes 3345 interactions was constructed using 234 disease. Integration of CFN showed 227 out 566 are significantly one...
There is accumulating evidence that the proteins encoded by genes associated with a common disorder interact each other, participate in similar pathways and share GO terms. It has been anticipated functional modules disease related linkage network are informative to reveal significant metabolic processes disease’s associations other complex disorders. In current study, Type 2 diabetes (T2DFN) containing 2770 15041 linkages was constructed. The this were scored evaluated terms of shared...
A closed-loop artificial pancreas has been the "Holy Grail" of efforts to improve medical care and lifestyle individuals with type 1 diabetes. In this talk we provide an overview research activities related pancreas, beginning a history glucose sensing technologies, insulin delivery systems, algorithms connect sensor signals rates. Current challenges include calibration errors signal artifacts, infusion set failure, uncertain meal dynamics, exercise effects, insulin-glucose sensitivity variability.
Individuals with type 1 Diabetes Mellitus (T1DM) must inject insulin to regulate blood glucose concentrations. The artificial pancreas project seeks automate the delivery of in response continuous monitor (sensor) signals. Most medical devices go through extensive animal studies before human can be conducted, but regulatory authorities (FDA, United States) have allowed investigators skip trials for by conducting exhaustive simulation-based (in silico) clinical trials. Still, current...
The development of a closed-loop artificial pancreas to regulate the blood glucose concentration individuals with type 1 diabetes has been focused area research for over 50 years, rapid progress during past decade. daily control challenges faced by someone include asymmetric objectives and risks, one-sided manipulated input action frequent relatively fast disturbances. major automation steps toward (i) monitoring overnight alarms hypoglycemia (low glucose); (ii) low suspend (LGS) systems...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinematics of Polymer Chains in Dense Media. 3. Influence Intramolecular Conformational PotentialsI. Bahar, N. Baysal, B. Erman, and L. MonnerieCite this: Macromolecules 1995, 28, 4, 1038–1048Publication Date (Print):February 1, 1995Publication History Published online1 May 2002Published inissue 1 February 1995https://pubs.acs.org/doi/10.1021/ma00108a035https://doi.org/10.1021/ma00108a035research-articleACS PublicationsRequest reuse...
Deriving autologous mesenchymal stem cells (MSCs) from adipose tissues without using enzymes requires sophisticated biomedical instruments. Applied pressure on and are adjusted manually although centrifugation filtration systems frequently used. The number of derived MSCs therefore could differ between We compared the obtained four commercially available devices our newly designed produced instrument (A2, B3, L3, M2 T3). Three-hundred mL tissue was a female patient undergoing liposuction...
Abstract Introducing Professional Skills during Unit Operations LaboratoryUnit operations laboratory (UOL) is considered to be a crucial and integral part of the chemicalengineering education. The major component course enable students combine theoryand practice. Problems in industry however always entail more than finding technical solutions.Indeed professional life requires other skills such as ability propose ideas, develop practicalsolutions, participate teamwork, meeting deadlines,...