A5023854818- Metal complexes synthesis and properties
- Molecular Sensors and Ion Detection
- Metal-Catalyzed Oxygenation Mechanisms
- Metal-Organic Frameworks: Synthesis and Applications
- Crystal structures of chemical compounds
- Protein Interaction Studies and Fluorescence Analysis
- Analytical Chemistry and Chromatography
- Trace Elements in Health
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Antibiotic Resistance in Bacteria
- Spectroscopy Techniques in Biomedical and Chemical Research
- Chemical and Physical Properties in Aqueous Solutions
- Oral microbiology and periodontitis research
- Antibiotics Pharmacokinetics and Efficacy
- DNA and Nucleic Acid Chemistry
- Corrosion Behavior and Inhibition
- Photochemistry and Electron Transfer Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Gout, Hyperuricemia, Uric Acid
- Electrochemical Analysis and Applications
- Lipid Membrane Structure and Behavior
- Free Radicals and Antioxidants
- Inorganic and Organometallic Chemistry
Medical University of Lodz
2010-2025
Isothermal titration calorimetry (ITC), circular dichroism (CD) spectroscopy, and molecular dynamics simulations were applied to describe interactions between lipopeptides decavanadate ions ([V10O28]6−). The selected are conjugates of the amide KR12 peptide, smallest antimicrobial peptide derived from human cathelicidin LL-37, with lauric acid (C12-KR12) myristic (C14-KR12). smaller sizes C12-KR12 C14-KR12 compared proteins allow for rigorous characterization their non-covalent highly...
Due to their excellent prospects in biological applications, Schiff bases and complexes are a source of continuing interest. The present study examines the formation four cobalt(II) with reduced base N-(2-hydroxybenzyl)phenylalanine (PhAlaSal) alkaline aqueous solution by pH-metry. UV-Vis ESI-MS studies confirmed model proposed species. Kinetic analysis indicated that single- bi-ligand transitioned from octahedral tetrahedral structures. its detected under physiological pH were tested for...
The present study describes the coordination properties of a reduced Schiff base, N-(2-hydroxybenzyl)alanine, towards cobalt(II) using potentiometric as well spectroscopic (UV-Vis and ESI-MS) methods. results indicate formation six mononuclear complexes showing high stability in aqueous solution. Coordination occurs {O−phenolic,N,O−carboxyl} {N,O−carboxyl} chelation modes, depending on degree ligand deprotonation. Examination complexation equilibria at pH ca 7, which is important from...
Mixed-ligand complexes of cobalt(II) with two bioligands, viz. 2-picolinehydroxamic acid and the reduced Schiff base N-(2-hydroxybenzyl)phenylalanine, were studied in aqueous solution by potentiometry UV–Vis spectroscopic analysis. The coordination mode their stability determined compared to parent species. Stacking interactions between rings present ligands influence complexes. Also, spectroscopy revealed that stacking affected intercalation DNA mixed-ligand vitro anticancer activity free...
Five new heteroligand cobalt(II) complexes with 2-picolinehydroxamic acid and reduced Schiff base, N-(2-hydroxybenzyl)alanine, were formed in an aqueous solution over a wide pH range. The coordination properties of ligands towards the metal ion determined using pH-metric method, then speciation model was confirmed by UV-Vis studies. A stacking interaction between base phenol ring pyridine found to improve stability species, indicating more effective mixed-ligand than their respective binary...
The paper examines Co(II)-amino acid-imidazole systems (where amino acid = L-α-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintaining the structural scheme of heme group (imidazole as axial ligand O2 uptake at sixth, trans position) thus imitating natural respiratory pigments such myoglobin hemoglobin. oxygenated reaction shows higher reversibility than for Co(II)-amac with analogous acids without imidazole....
The present work describes the protolytic properties of sialorphin derivative (Pal-Lys- Lys-Gln-His-Asn-Pro-Arg) in an aqueous solution, at constant temperature 25.0 ± 0.1 °C and ionic strength M (NaClO4), over entire pH range. overall protonation constants studied ligand were calculated by potentiometric method. logarithm values stepwise dissociation found to be: [LH] = 11.88 0.09, [LH2]+ 9.96 0.03, [LH3]2+ 8.71 [LH4]3+ 5.49 [LH5]4+ 2.82 0.03. percentage each species formed solution was...
In the present study, complexing properties of ceftazidime with Fe(III) ions in aqueous solutions were characterized by UV-vis spectrophotometric and potentiometric methods. Using method, absorbance values for ions, a third-generation cephalosporin antibiotic (ceftazidime), Fe(III)-ceftazidime system determined. Based on pH-metric studies, value stability constant complex was calculated.
The present work describes the complexation properties of two oxime-containing Schiff bases (used as ligands), viz. 2-hydroxyimino-N′-[1-(2-pyridyl)ethylidene]propanohydrazone (Hpop) and 2-hydroxyimino-N′-[(pyridine-2-yl)methylidene]propanohydrazone (Hpoa), with Co(II) ions in DMSO/water solution. Volumetric (oxygenation) studies were carried out to determine uptake molecular oxygen O2 formation complexes Co(II)-Hpop Co(II)-Hpoa. acquired data can be useful development bioinorganic metal...
The present work describes the complexation properties of two synthetic nucleosides (used as ligands), i.e. β-D-ribofuranoside-4-pyrimidinone (ribo) and β-D-deoxyribofuranoside-4-pyrimidinone (deoxy) with Ag(I) ions in aqueous solution. stability constants studied coordination entities were calculated potentiometrically. logarithm values overall found to be [Ag-deoxy]+ = 3.07, [Ag-(deoxy)2]+ 6.90, [Ag-ribo]+ 3.00 [Ag-(ribo)2]+ 6.63. Based on species distribution curves a function CL/CM,...
The present work describes the complexation of anti-inflammatory sialorphin derivative Pal-Lys-Lys-Gln-His-Asn-Pro-Arg (palmitic acid-lysine-lysine-glutamine-histidine-asparagine-proline-arginine) with Cu(II) ions in an aqueous solution, at a temperature 25.0 ± 0.1 °C, over whole pH range. complexing properties were characterized by potentiometric and UV-Vis spectrophotometric methods. method was used to calculate logarithms overall stability constants (log β) values stepwise dissociation...
The present study describes the coordination properties of a reduced Schiff base, N-(2-hydroxybenzyl)phenylalanine, towards cobalt(II) using potentiometric method. speciation model was confirmed by UV–Vis studies. appearance precipitate in pH range 2-7.3 meant that measurements aqueous solution were only possible an alkaline medium. results show formation four mononuclear complexes with different degree ligand deprotonation. At physiological pH, antimicrobial N-(2-hydroxybenzyl)phenylalanine...