A5076147807- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Chemokine receptors and signaling
- Atherosclerosis and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Cardiac Fibrosis and Remodeling
- Phagocytosis and Immune Regulation
- Galectins and Cancer Biology
- Cytokine Signaling Pathways and Interactions
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Viral Infections and Immunology Research
- Apelin-related biomedical research
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Protein Tyrosine Phosphatases
South Tees Hospitals NHS Foundation Trust
2024
Freeman Hospital
2021-2023
Newcastle University
2023
James Cook University Hospital
2023
Newcastle upon Tyne Hospitals NHS Foundation Trust
2023
Cardiovascular disease is the primary cause of mortality and morbidity in patients with chronic kidney (CKD), particularly those end stage renal (ESRD) undergoing hemodialysis. This paper examines challenges managing acute coronary syndrome (ACS) ESRD patients, focusing on delicate balance between thrombotic bleeding risks. The review explores mechanisms underlying increased risk ESRD, including elevated platelet aggregation, endothelial dysfunction, alterations coagulation factors....
Abstract Background The fractalkine receptor CX3CR1 has been linked to the development of microvascular obstruction (MVO) in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI). Pre-clinical studies have demonstrated a reduction infarct size, inflammation and intramyocardial haemorrhage (IMH) with inhibition CX3CR1. Purpose FRACTAL study is phase IIa, pilot, randomized, 2-arm parallel group, placebo-controlled, double blinded,...
Abstract Background We have previously demonstrated a strong association between expression of the fractalkine receptor CX3CR1 on lymphocytes and microvascular obstruction (MVO) in patients undergoing primary percutaneous coronary intervention (PPCI) for ST-elevation myocardial infarction. Our pre-clinical studies also found an improvement infarct size, inflammation intramyocardial haemorrhage (IMH) when rats were pre-treated with inhibitor KAND567. Purpose FRACTAL (FRACTalkine inhibition...