Epithelixal ovarian cancer is the fourth cause of death in developed countries with 77% cases diagnosed regional or distant metastasis, poor survival rates. Docetaxel (DTX) a well-known anticancer agent, clinically proven efficacy several malignancies, including cancer. However, adverse effects caused by active ingredient currently marketed formulations could even deprive patient advantages treatment. Therefore, current study, polymeric nanoparticles (NPs) equipped aptamer molecules as...

Background: Actinic keratosis (AK) is a precancerous skin condition caused by abnormal growth of epidermal keratinocytes. Current treatments, like 5-fluorouracil (5-FU) cream, have limitations. Rosemary extract has shown anticancer and antioxidant properties, enhancing the effects 5-FU. Nanofibers are potential drug delivery system due to their unique properties. Thus, this study aimed investigate efficacy 5-FU rosemary extract-loaded nanofibers in AK treatment. Methods: Polymeric loaded...

Background: There are considerable attempts worldwide on herbal and traditional compounds to validate their use as anti-cancer drugs. Plants from Moringaceae family including Moringa oleifera possess several activities such antitumor effect tumor cell lines. In this study we sought determine if callus leaf extracts of M. any cytotoxicity. Materials Methods: Ethanol-water (70-30) were prepared by maceration method. The amount phenolic the was determined Folin Ciocalteu cytotoxicity against...

The objective of the present study was fabrication a wound dressing membrane based on RGD modified polybutylene adipate-co-terephthalate (PBAT)/gelatin nanofibrous structures loaded with doxycycline (DOX). This type nanofiber for healing has not been reported so far and is quite novel. PBAT gelatin nanofibers were separately electrospun using double needles electrospinning setup. Electrospinning variables optimized to obtain bead-free thin nanofibers. amount drug release measured in...

The purpose of this study was to design 5-fluorouracil-loaded poly(butylene adipate)/terephthalate (Ecoflex ® ) nanoparticles for targeting colorectal cancer. were prepared by emulsification–solvent evaporation method and optimized a full factorial design. effects polymer surfactant concentration, type, stirrer rate studied on the particle size, zeta potential, loading efficiency, release efficiency nanoparticles. For production targeted nanoparticles, chitosan conjugated transferrin which...

The purpose of the study was to enhance solubility poorly water-soluble drug, Repaglinide using spray drying based solid dispersion technique by different carriers including Eudragit E100, hydroxyl propyl cellulose Mw 80 000 and poly vinyl pyrollidone K30. Optimization best formulation carried out according drug solubility, release profile, particle size angle repose dispersions. optimized sample characterized X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) Fourier...

Ovarian cancer is still a major cause of morbidity and mortality. Docetaxel (DTX) one the most notable cytotoxic agents for treatment ovarian cancer. However, its side effects proposed considerable problems to patients.Polymeric nanoparticles (NPs) poly (butylene adipate-co-butylene terephthalate) (Ecoflex®), biodegradable biocompatible polymer, were prepared first time by upgradeable electrospraying technique.The formulation procedure variables optimized using Design Expert software, effect...

Status epilepticus is associated with substantial morbidity and neuronal necrosis, the duration of seizure would affect its following complications. Eliminating have valuable outcomes; however, presence BBB an obstacle. The purpose current study was to achieve a nose-to-brain magnetic drug delivery system accelerate onset action, reduce mucociliary clearance via implementing field.The drug-entrapped nanoaggregates were prepared 2-step method, synthesis nanoparticles loading. Optimization...

Nervous patients often postpone dental visits until they are in severe pain, exacerbating anxiety. Buccal patches provide a noninvasive method of delivering drugs between the upper gum and cheek, offering local systemic effects. Prior research has demonstrated effectiveness, safety, reliability topical lidocaine or articaine for oral anesthesia. Consequently, this study aimed to develop three-layered buccal drug delivery system anesthetics.

Breast cancer is a major cause of mortality. Regarding the advantages polymeric nanoparticles as drug delivery systems with targeting potential, in this study antitumor mechanism targeted docetaxel Ecoflex® was exploited. Since overexpression HER-2 receptor breast cases associated poor prognosis and more aggressive disease, proposed were conjugated to specific aptamer molecules. In vitro cytotoxicity evaluated by MTT assay. Flow-cytometry analysis performed evaluate cellular uptake loaded...

Docetaxel is a notably efficient anticancer drug administered for several types of malignancies including ovarian cancer. However, various side effects caused either by the nonspecific distribution active ingredient or high contents Tween 80 and ethanol in currently marketed formulations, could even deprive patients treatment.In current study, novel targeted delivery system composed Ecoflex® polymeric nanoparticles loaded with docetaxel equipped HER-2 specific aptamer molecules was evaluated...

Human epidermal growth factor receptor 2 (HER-2) is overexpressed in 20–30% of human breast cancers, associated with poor prognosis and tumour aggression. The aim this study was the production trastuzumab-targeted Ecoflex nanoparticles (NPs) loaded docetaxel vitro evaluation their cytotoxicity cellular uptake. NPs were manufactured by electrospraying characterised regarding size, zeta potential, drug loading, release behaviour. Then evaluated MTT assay against an HER-2-positive cell line,...

Background: Topical 5-fluorouracil (5FU) is one of the most prescribed medications for different types skin cancer; however, it associated with drug resistance and adverse effects. Rosemary extract has promising dose-dependent antitumor effects, as well a synergistic effect in combination 5-fluorouracil, besides sensitization 5-FU-resistant cells. Objective: Polymeric nanofibers loaded 5FU rosemary were optimized to combine both ingredients controlled release delivery system, aiming enhance...

Introduction: A bio-implant is a drug-delivery system that implanted in the human body for period of more than 30 days. Electromechanical systems are one type has recently been introduced as new generation targeted drug delivery methods. The overarching goal utilizing these to integrate electrical and mechanical features order benefit from numerous applications two when used together. current study aimed design prototype an electromechanical using Fused Deposition Modeling (FDM), Selective...

Despite many attempts to treat leishmaniasis, new approaches are necessary reduce the burden of disease.