Paola Astolfi

ORCID: 0000-0003-3226-082X
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About
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Research Areas
  • Demographic Trends and Gender Preferences
  • X-ray Diffraction in Crystallography
  • Crystallization and Solubility Studies
  • Birth, Development, and Health
  • Electron Spin Resonance Studies
  • Free Radicals and Antioxidants
  • Antioxidant Activity and Oxidative Stress
  • Global Maternal and Child Health
  • Phytochemicals and Antioxidant Activities
  • Insurance, Mortality, Demography, Risk Management
  • Bee Products Chemical Analysis
  • Skin Protection and Aging
  • Pregnancy and preeclampsia studies
  • Lipid Membrane Structure and Behavior
  • Photochemistry and Electron Transfer Studies
  • Insect and Pesticide Research
  • Genetic and phenotypic traits in livestock
  • Chemical Reaction Mechanisms
  • Evolutionary Psychology and Human Behavior
  • Genetic diversity and population structure
  • Family Dynamics and Relationships
  • Plant and animal studies
  • Mitochondrial Function and Pathology
  • Oxidative Organic Chemistry Reactions
  • Assisted Reproductive Technology and Twin Pregnancy

Marche Polytechnic University
2014-2024

Ospedali Riuniti di Ancona
2001-2019

Hospital de Base
2015

University of Pavia
2002-2014

Università di Camerino
1996-1997

Istituto di Genetica Molecolare
1989-1990

Sapienza University of Rome
1988

Institute of Genetics and Biophysics
1987

Stanford University
1985

University of Milan
1983-1985

Coral bleaching (i.e., the release of coral symbiotic zooxanthellae) has negative impacts on biodiversity and functioning reef ecosystems their production goods services. This increasing world-wide phenomenon is associated with temperature anomalies, high irradiance, pollution, bacterial diseases. Recently, it been demonstrated that personal care products, including sunscreens, have an impact aquatic organisms similar to other contaminants.Our goal was evaluate potential sunscreen...

10.1289/ehp.10966 article EN public-domain Environmental Health Perspectives 2008-01-03

Bond dissociation enthalpies (BDE) of hydroxylamines containing alkyl, aryl, vinyl, and carbonyl substituents at the nitrogen atom have been determined by using EPR radical equilibration technique in order to study effect on O-H bond strength these compounds. It has found that substitution an alkyl group directly bonded with vinyl or aryl groups a small effect, while acyl induces large increase BDE value. Thus, dialkyl strengths only ca. 70 kcal/mol, acylhydroxylamines N-hydroxyphthalimide...

10.1021/jo026660z article EN The Journal of Organic Chemistry 2003-02-01

Background and Aim Free radicals are implicated in the aetiology of gastrointestinal disorders such as gastric ulcer, colorectal cancer inflammatory bowel disease. Strawberries common important fruit due to their high content essential nutrient beneficial phytochemicals which seem have relevant biological activity on human health. In present study we investigated antioxidant protective effects three strawberry extracts against ethanol-induced mucosa damage an experimental vivo model test...

10.1371/journal.pone.0025878 article EN cc-by PLoS ONE 2011-10-07

Bulk methyl methacrylate (MMA) controlled radical polymerization was carried out using two 2,2-diphenyl-3-phenylimino-2,3-dihydroindol-1-yloxyl nitroxide (DPAIO) based alkoxyamines. Whatever the alkoxyamine used, presents a character, and high conversion can be reached. Polymerization up to 60% conversion, initiated with nitro para-substituted 2, showed linear increase of number-average molecular weight (Mn) vs even at beginning final polydispersity index (PDI) close 1.4. A reinitiation test...

10.1021/ma062330v article EN Macromolecules 2007-04-11

The risk of preterm delivery in a recent sample (1990–1994) Italian liveborns was examined, taking into account child birth order, and maternal age education addition to the fetal gender. Univariate analyses showed that higher associated with male than female babies, first- second-born children, older mothers, less educated mothers. relative weights factors examined were evaluated through logistic regression highest lowest risks found be advanced gender respectively. Our findings therefore...

10.1093/humrep/14.11.2891 article EN Human Reproduction 1999-11-01

New mediators of laccase have been comparatively evaluated and ranked towards the benchmark aerobic oxidation p-MeO-benzyl alcohol. The mechanism this non-phenolic substrate by each mediator, which is initially oxidised to Medox form, has assessed among three alternatives. latter make phenoloxidise competent for indirect (and thus 'unnatural') substrates. Experimental characterisation mediators, means spectrophotometric, electrochemical thermochemical survey, reported. Clear-cut evidence...

10.1039/b507657a article EN New Journal of Chemistry 2005-01-01

The influence of commonly used steeping times and temperatures, as well leaf size on the antioxidant activity sensory attributes tea were studied. Five unblended white green samples from China Malawi, infused in hot (70 °C 90 °C; 7 min) or cold water (room temperature: 15, 30, 60, 120 either whole leaves milled, analyzed. Total phenolic flavonoid contents power (ABTS assay) measured. results show that maximum extraction efficiency occurs with for min at only case teas whole, large leaves,...

10.3109/09637486.2015.1042842 article EN International Journal of Food Sciences and Nutrition 2015-05-28

Lyotropic cubic liquid-crystalline systems have received increasing attention due to their unique microstructural and physicochemical properties as efficient nanocarriers for drug delivery. We report the preparation characterization of bulk phases cubosome dispersions phytantriol loaded with anticancer 5-fluorouracil, in neutral anionic forms. In both cases, a Pn3m phase was observed. The behavior can be influenced by addition ionic agents, and, this purpose, positively charged lipid, such...

10.1021/acs.langmuir.7b03173 article EN Langmuir 2017-10-12

Summary We evaluated the effect of mother’s age on risk unfavourable pregnancy outcome. The study considered 1348 190 first‐born and 957 689 second‐born babies born in Italy 1990–94. stillbirth, preterm birth liveborns, low birthweight liveborns at term, was first separately then globally as a function maternal age, education parity. Older (≥ 35 years) mothers were found to run an increased risk, both single global evaluation, with respect their younger counterparts. Primiparae ≥ years...

10.1046/j.1365-3016.2002.00375.x article EN Paediatric and Perinatal Epidemiology 2002-01-01

Abstract Fourier‐transform infrared hyperspectral imaging (FTIR‐HSI) provides images containing both morphological and chemical information. It is widely applied in the biomedical field to detect tumor lesions, even at early stage, by identifying specific spectral biomarkers. Pancreatic neoplasms present different prognoses are not always easily classified conventional analyses. In this study, tissue samples with diagnosis of pancreatic ductal adenocarcinoma neuroendocrine were analyzed...

10.1002/jbio.201960071 article EN Journal of Biophotonics 2019-10-24

Bee pollen loads generally have a homogeneous and monospecific content assume typical form color, due to the bee foraging habits, thus having composition related botanical origin. The present study aims characterize belonging different species using morphological, spectroscopic color properties find relationships between these variables. IR spectra analysis allowed reliable picture of components in samples; granulometry permits visual identification load species. Multivariate enabled...

10.3390/molecules24213974 article EN cc-by Molecules 2019-11-03

Advanced paternal age has been reported to impair pregnancy outcome. Here, we investigated the association of advanced with preterm birth by using a very large national data set.We analyzed from 1990 1998 on Italian firstborn singletons mothers 20-24 and 25-29 years (n = 1,510,823). Odds ratios for overall (<37 weeks' gestation), (<32 weeks), moderate (32-36 weeks) births were evaluated through logistic regression models in classes (20-24, 25-29, 30-34, 35-39, 40-44, 45-49, 50+ years) after...

10.1097/01.ede.0000197053.61176.f4 article EN Epidemiology 2006-02-13

AbstractPhoto-instability of common UV-filters is a well documented phenomenon. This study develops method for concomitant measurement photostability and photo-induced ROS generation in cosmetic formulations. Oil-in-water formulations containing three UV filters (OMC, BMDBM, EHT), individually or combined, were further supplemented with phosphatidylcholine exposed to UVA. All show spectral decrease after UVA exposure. OMC EHT do not induce significant lipid-peroxidation (as measured by TBARS...

10.3109/10715760903486065 article EN Free Radical Research 2010-01-01

Indolinic nitroxides derived from 2,2-diphenyl-3-phenylimino-2,3-dihydroindol-1-yloxyl (DPAIO) nitroxide were designed to improve the bulk polymerization of methacrylate derivatives. The corresponding alkoxyamines prepared by reacting alkyl halide and in presence tin hydride PbO2. replacement one phenyl ring at C-2 position on either a neopentyl or an isopropyl group led compounds with faster decomposition kinetics better selectivity for C–ON bond homolysis. these two used control methyl...

10.1039/c3py00368j article EN Polymer Chemistry 2013-01-01

Background UVA rays present in sunlight are able to reach the dermal skin layer generating reactive oxygen species (ROS) responsible for oxidative damage, alterations gene expression, DNA leading cell inflammation, photo-ageing/-carcinogenesis. Sunscreens contain UV filters as active ingredients that absorb/reflect/dissipate radiation: their efficiency depends on spectral profile and photostability which should then be reflected biological protection of underlying skin. Methods A set new was...

10.1371/journal.pone.0083401 article EN cc-by PLoS ONE 2014-01-07
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