A5077466206- Drug Solubulity and Delivery Systems
- Microfluidic and Capillary Electrophoresis Applications
- Analytical Chemistry and Chromatography
- Hydrogels: synthesis, properties, applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Quantum Chemical Studies
- DNA and Nucleic Acid Chemistry
- Ionic liquids properties and applications
- Advanced biosensing and bioanalysis techniques
- Crystallization and Solubility Studies
- Surfactants and Colloidal Systems
- Protein Interaction Studies and Fluorescence Analysis
- RNA Interference and Gene Delivery
- Protein Structure and Dynamics
- Nanocluster Synthesis and Applications
- Crystallography and molecular interactions
- Chemical and Physical Properties in Aqueous Solutions
- Cultural Heritage Materials Analysis
- Supramolecular Self-Assembly in Materials
- Advanced Drug Delivery Systems
- Glass properties and applications
- Nanoparticle-Based Drug Delivery
- Material Dynamics and Properties
- NMR spectroscopy and applications
- Molecular spectroscopy and chirality
Elettra-Sincrotrone Trieste S.C.p.A.
2016-2025
University of Trento
2014-2024
University of Trieste
2019-2022
Institute of Bioorganic Chemistry
2021
Centre National de la Recherche Scientifique
2020
Ho Chi Minh City University of Technology and Education
2020
Enrico Fermi Center for Study and Research
2019
National Interuniversity Consortium of Materials Science and Technology
2014-2016
University of Verona
2009-2013
University of Padua
2012
Hydrogen peroxide to propylene oxide (HPPO) reaction is an attractive process exploiting titanium silicalite-1 (TS-1) as a catalyst in combination with aqueous hydrogen oxidizing agent. Beyond the industrial interest, TS-1 represents one of most widely characterized catalysts due its unique properties. However, unified description on speciation different Ti species and their correlation catalytic performances missing literature. This work aims exploit spectroscopic techniques (namely,...
Invertebrates represent the most plentiful component of marine biodiversity. To date, only few species have been documented for litter intake. Here, we report first time presence macroplastic debris in a jellyfish species. Such novel target to plastic pollution highlights an under studied vector along trophic web, raising further concern over impact on wildlife.
Lyotropic cubic liquid-crystalline systems have received increasing attention due to their unique microstructural and physicochemical properties as efficient nanocarriers for drug delivery. We report the preparation characterization of bulk phases cubosome dispersions phytantriol loaded with anticancer 5-fluorouracil, in neutral anionic forms. In both cases, a Pn3m phase was observed. The behavior can be influenced by addition ionic agents, and, this purpose, positively charged lipid, such...
Unlike the archetypal deep eutectic solvent (DES) choline chloride:urea (ChCl:U), fundamental knowledge of intermolecular network in acetate (ChOAc) DESs and how they change upon dilution is still missing. Here we jointly use UV resonance Raman (UVRR) NMR spectroscopy to comparatively explore strength distribution hydrogen bonding solvation components are modified ChOAc:U ChCl:U with increasing hydration. Overall, data indicate that continuously affected by hydration and, even at low water...
Ibuprofen sodium salt (IP) was encapsulated in cyclodextrin nanosponges (CDNS) obtained by cross-linking of β-cyclodextrin with ethylenediaminetetraacetic acid dianhydride (EDTAn) two different preparations: CDNSEDTA 1:4 and 1:8, where the 1: n notation indicates CD to EDTAn molar ratio. The entrapment IP achieved swelling polymers a 0.27 M solution D 2 O, leading colourless, homogeneous hydrogels loaded IP. molecular environment transport properties were studied high resolution magic angle...
An integrated experimental approach, based on inelastic light-scattering techniques, has been here employed for a multilength scale characterization of networking properties cyclodextrin nanosponges, new class cross-linked polymeric materials built up from natural oligosaccharides cyclodextrins. By using Raman and Brillouin scattering experiments, we performed detailed inspection the vibrational dynamics these polymers over wide frequency window ranging gigahertz to terahertz, with aim...
Vanillin (4-hydroxy-3-methoxybenzaldehyde) is a phenolic aldehyde with limited solubility in water; this work, we investigate its self-aggregation, as well complexation equilibria β-cyclodextrin by using nuclear magnetic resonance (NMR) and vibrational spectroscopy. In particular, diffusion-ordered NMR (DOSY) measurements allowing to detect diffusional changes caused aggregation/inclusion phenomena lead reliable estimate of the equilibrium constants these processes, while Raman spectroscopy...
The vibrational dynamics of cyclodextrin nanosponges (CDNS), a new class nanostructured soft materials synthesized via cross-linking reaction natural cyclic oligosaccharide β-cyclodextrin (β-CD) with suitable organic reagents, is investigated by means the combined use Raman and infrared spectroscopy, supported numerical simulations. spectra polymers show significant changes in frequency ranges 3000-3700 1500-1800 cm(-1) correlated to relative amount cross-linker respect monomeric CD. By...
We report on the use of UV Raman technique to monitor oxidative damage deoxynucleotide triphosphates (dATP, dGTP, dCTP and dTTP) DNA (plasmid vector) solutions. Nucleotide aqueous solutions were exposed hydrogen peroxide (H2O2) iron containing carbon nanotubes (CNTs) produce Fenton's reaction induce damage. spectroscopy is shown be maximally efficient reveal changes in nitrogenous bases during mechanisms occurring these molecules. The analysis spectra, supported by numerical computations,...
The vibrational dynamics of a new class cyclodextrin-based hydrogel is explored in depth here with the aim to clarify intimate relationship between structural and functional properties these innovative polymeric materials. thorough quantitative analysis FTIR-ATR Raman spectra obtained by swelling cross-linked polymers cyclodextrins heavy water performed wavenumber range 1600 1800 cm−1 using best-fitting deconvolution procedures. use D2O instead H2O allowed us separately examine CO stretching...
The vibrational dynamics of a new class cross‐linked polymers obtained from both native and modified cyclodextrin, referred to as cyclodextrin nanosponges, is here investigated. main purpose spot the structure these materials at molecular level unlikely be characterized by diffraction methods due low or null degree crystallinity. analysis spectral features bands observed between 1650 1800 cm −1 in Raman infrared spectra, assigned carbonyl stretching modes polymeric network, performed using...
A multi-technique approach, combining circular dichroism spectroscopy, ultraviolet resonance Raman spectroscopy and small angle scattering techniques, has been deployed to elucidate how the structural features of human telomeric G-quadruplex d[A(GGGTTA)3GGG] (Tel22) change upon thermal unfolding. The system is studied both in free form when it bound Actinomycin D (ActD), an anticancer ligand with remarkable conformational flexibility. We find that at room temperature binding Tel22 ActD...
UV resonance Raman spectroscopy of size-selected linear sp-carbon chains unveils vibrational overtones and combinations up to the fifth order. Thanks tunability synchrotron source, we excited each H-terminated polyyne (HCnH with n = 8,10,12) maxima its vibronic absorption spectrum allowing us precisely determine electronic structure ground states for main observed mode. Selected transitions are shown enhance specific overtone orders in a way that can be explained by simple analytical model...
Ultrafast optical-domain spectroscopies allow to monitor in real time the motion of nuclei molecules. Achieving element-selectivity had await advent resolved X-ray spectroscopy, which is now commonly carried at free electron lasers. However, detecting light element that are encountered organic molecules, remained elusive due need work under vacuum. Here, we present an impulsive stimulated Raman scattering (ISRS) pump/carbon K-edge absorption probe investigation, allowed observation...
We investigate resonance (true and pre-resonance) Raman (RR) effects in glucose, galactose, N-acetylglucosamine, N-acetylgalactosamine with ultraviolet (UVRR) far-ultraviolet (FUV) spectroscopies. Electronic transitions the FUV region are attributed to electronic orbitals due σ π electrons. Their geometric orientations that participate effect have not yet been well studied, unlike those for visible near-infrared RR In this study, we employed monosaccharides their derivatives an amino group,...
Abstract The modifications to the vibrational spectra produced by inclusion into cyclodextrins on of non‐steroidal anti–inflammatory drug ibuprofen, have been investigated means Raman scattering and numerical simulation. These changes are discussed explained comparison with theoretical wavenumbersfrequencies intensities obtained quantum classical simulations, disentangling effects directly related complexation process, from those be ascribed non‐covalent dimerization ibuprofen due hydrogen...
The vibrational dynamics of solid inclusion complexes the nonsteroidal anti-inflammatory drug Ibuprofen (IBP) with beta-cyclodextrin (beta-CD) and methyl-beta-cyclodextrin (Me-beta-CD) has been investigated by using attenuated total reflection-Fourier transform infrared FTIR-ATR spectroscopy, in order to monitor changes induced, as a consequence complexation, on spectrum IBP, wavenumber range 600-4000 cm(-1). Quantum chemical calculations were performed monomeric dimeric structures derived...
An integrated experimental-numerical approach, based on vibrational spectroscopy techniques and quantum chemical computation methods, has been here implemented tested a new class of cyclodextrin-based cross-linked polymers, namely, cyclodextrins nanosponges. By the simultaneous quantitative analysis FTIR-ATR Raman spectra in frequency domains between 1650-1800 3000-3700 cm(-1), we individuated reliable physical descriptors directly connected to cross-linking degree polymeric matrices. The...
A new hyper-branched water-soluble polymer was synthesized by reacting β-cyclodextrin with pyromellitic dianhydride beyond the critical conditions that allow phenomenon of gelation to occur. The molar ratio between monomers is a crucial parameter rules process. Nevertheless, concentration in solvent phase plays key role as well. Hyper-branched β-cyclodextrin-based polymers were obtained performing syntheses excess and cross-linking agent, for dilution determined experimentally. very high...