A5001869354- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Microfluidic and Capillary Electrophoresis Applications
- Microencapsulation and Drying Processes
- Phytochemicals and Antioxidant Activities
- Advancements in Transdermal Drug Delivery
- Surfactants and Colloidal Systems
- Thermodynamic properties of mixtures
- Lipid Membrane Structure and Behavior
- Phytoestrogen effects and research
- Protein Interaction Studies and Fluorescence Analysis
- Essential Oils and Antimicrobial Activity
- Analytical Methods in Pharmaceuticals
- Microbial Metabolites in Food Biotechnology
- Protein purification and stability
- Advanced Chemical Sensor Technologies
- Mass Spectrometry Techniques and Applications
- Natural product bioactivities and synthesis
- thermodynamics and calorimetric analyses
- Proteins in Food Systems
- Free Radicals and Antioxidants
- Spectroscopy Techniques in Biomedical and Chemical Research
University of Messina
2013-2025
Instituto Biológico
2016
Bulgarian Academy of Sciences
2009
University of Catania
2009
National Interuniversity Consortium for the Physical Sciences of Matter
2009
University of Perugia
2009
Istituto di Metodologie Chimiche
2003
Idebenone (IDE) is an antioxidant drug active at the level of central nervous system (CNS), whose poor water solubility limits its clinical application. An IDE/2-hydroxypropyl-β-cyclodextrin (IDE/HP-β-CD) inclusion complex was investigated by combining experimental methods and theoretical approaches. Furthermore, biological in vitro/ex vivo assays were performed. Phase studies showed AL type diagram, suggesting presence a 1:1 with high solubility. Scanning electron microscopy (SEM) allowed...
This study was aimed at preparing and characterizing solid lipid nanoparticles loading rutin (RT-SLNs) for the treatment of oxidative stress-induced diseases. Phospholipon 80H® as a Polysorbate 80 surfactant were used SLNs preparation, using solvent emulsification/diffusion method. We obtained spherical RT-SLNs with low sizes, ranging from 40 to 60 nm (hydrodynamic radius) prepared starting 2% 5% (w/w) theoretical amount. All formulations showed negative zeta-potential values. RT efficiently...
Recent findings suggest that visible light-promoted photooxidative processes mediated by sensitizers of appropriate chemical structure could represent a useful tool for properly addressing the problem increasing occurrence infectious diseases caused multiantibiotic-resistant microbial pathogens. The monocationic meso-substituted porphyrin 5-[4-(1-dodecanoylpyridinium)]-10,15,20-triphenyl-porphine (TDPyP) complexed into supramolecular aggregates cationic amphiphilic β-cyclodextrin (SC6NH2)...
In the present study, we developed chitosan/hyaluronan nanoparticles (CS/HY NPs) for tumor targeting with vinblastine sulfate (VBL), that can be directed to CD44 transmembrane receptor, over-expressed in cancer cells. NPs were prepared by coating HY-preformed chitosan/tripolyphosphate (CS/TPP) NPs, or polyelectrolyte complexation of CS HY. a mean hydrodynamic radius (RH) 110 nm, 12% polydispersity index and negative zeta potential values obtained direct process. Transmission Electron...
In recent years, bioactive compounds have been the focus of much interest in scientific research, due to their low toxicity and extraordinary properties. However, they possess poor solubility, chemical stability, unsustainable bioavailability. New drug delivery systems, among them solid lipid nanoparticles (SLNs), could minimize these drawbacks. this work, morin (MRN)-loaded SLNs (MRN-SLNs) were prepared using a solvent emulsification/diffusion method, two different lipids, Compritol® 888...
The vibrational dynamics of solid inclusion complexes the nonsteroidal anti-inflammatory drug Ibuprofen (IBP) with beta-cyclodextrin (beta-CD) and methyl-beta-cyclodextrin (Me-beta-CD) has been investigated by using attenuated total reflection-Fourier transform infrared FTIR-ATR spectroscopy, in order to monitor changes induced, as a consequence complexation, on spectrum IBP, wavenumber range 600-4000 cm(-1). Quantum chemical calculations were performed monomeric dimeric structures derived...
Currently, problems related to antibiotic resistance are shifting the focus of pharmaceutical research towards natural molecules with antibacterial properties. Among them, flavonoids represent promising strong features; however, they have poor biopharmaceutical In this study, we developed solid lipid nanoparticles (SLNs) loaded flavanone naringenin (NRG) offer an option for treating bacterial infections. NRG-SLNs systems were prepared by a solvent emulsification/diffusion and ultrasonication...
Treatment of biofilm-related infections represents a major challenge in public health management. Therefore, the accurate identification both composition and architecture bacterial biofilms, terms microorganisms surrounding extracellular polymeric substances (EPSs), fundamental pre-requisite for rapid diagnosis recurrent/resistant biofilm-based as well management several industrial processes. In this work, results combined approach involving scanning electron microscopy (SEM),...