A5078511360- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Synthetic Organic Chemistry Methods
- Synthesis and Biological Activity
- Chemical synthesis and alkaloids
- Seaweed-derived Bioactive Compounds
- Traditional and Medicinal Uses of Annonaceae
- Bioactive Compounds and Antitumor Agents
- Marine Toxins and Detection Methods
- Coral and Marine Ecosystems Studies
- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Genomics and Phylogenetic Studies
- Cancer therapeutics and mechanisms
- Phytochemistry and Biological Activities
- Synthesis and Characterization of Heterocyclic Compounds
- Mass Spectrometry Techniques and Applications
- Ionic liquids properties and applications
- Synthesis and biological activity
- Echinoderm biology and ecology
- Cholinesterase and Neurodegenerative Diseases
- Crystallization and Solubility Studies
- Molecular spectroscopy and chirality
- Marine and coastal plant biology
- Synthesis and Reactivity of Heterocycles
University of Trento
2016-2025
Institute of Bioorganic Chemistry
2021
Bepress (United States)
2015
University of Ljubljana
1997
Cheikh Anta Diop University
1994
University of Pisa
1993
Glioblastoma stem cells (GSCs) resist current glioblastoma (GBM) therapies. GSCs rely highly on oxidative phosphorylation (OXPHOS), whose function requires mitochondrial translation. Here we explore the therapeutic potential of targeting translation and report results high-content screening with putative blockers ribosomes. We identify bacterial antibiotic quinupristin/dalfopristin (Q/D) as an effective suppressor GSC growth. Q/D also decreases clonogenicity in vitro, consequently...
YTHDF proteins bind the N6-methyladenosine (m6A)-modified mRNAs, influencing their processing, stability, and translation. Therefore, members of this protein family play crucial roles in gene regulation several physiological pathophysiological conditions. contain a hydrophobic pocket that accommodates m6A embedded RRACH consensus sequence on mRNAs. We exploited presence cage to set up an m6A-competitive assay performed high-throughput screen aimed at identifying ligands binding pocket....
Abstract Electrospray ionization‐quadrupole ion trap mass spectrometry (ESI‐QITMS), either in positive‐ or negative‐ion mode, has been used to establish the chemical structures (chain length, degree of unsaturation, positional distribution) fatty acids attached primary ( sn ‐1) and secondary ‐2) hydroxyl groups glycerol moiety natural monogalactosyl‐ (MGDG) digalactosyldiacylglycerols (DGDG), isolated from freshwater dinoflagellate Glenodinium sanguineum a marine diatom belonging genus...
Abstract Recent computational advancements in the simulation of biochemical processes allow investigating mechanisms involved protein regulation with realistic physics-based models, at an atomistic level resolution. These techniques allowed us to design a drug discovery approach, named Pharmacological Protein Inactivation by Folding Intermediate Targeting (PPI-FIT), based on rationale negatively regulating levels targeting folding intermediates. Here, PPI-FIT was tested for first time...
As a bulk component of plant biomass, cellulose plays key role in the route leading to viable chemicals from renewable resources. Pyrolysis is thermal treatment that converts into liquid material (bio-oil) containing dehydrated monomers, among which anhydrosugars levoglucosan (LGA) and levoglucosenone (LGO) have been widely investigated as chiral multifunctional synthons. A cyclic hydroxylactone (LAC, 1) also produced, but its potential chemical intermediate has never scrutinised, probably...
Abstract From the scleractinian coral Tubastraea sp. (Dendrophylliidae) collected at Palawan, Philippines, 3′‐deimino‐3′‐oxoaplysinopsin ( 4 ) and 6‐bromo‐3′‐deimino‐3′‐oxoaplysinopsin 6 are now isolated as 5:2 mixtures of E/Z stereoisomers. The 3′‐deimino‐2′,4′‐bis(demethyl)‐3′‐oxoaplysinopsin 7 6‐bromo‐3′‐demino‐2′,4‐bis(demethyl)‐3′‐oxoaplysinopsin 5 2:3 1:1 mixtures, respectively, from another dendrophylliid, Leptopsammia pruvoti , near Marseille, Mediterranean coast France. Larger...
Abstract The dendrophylliid Dendrophyllia sp. of Palawan contains the indole alkaloids 2′‐demethylaplysinopsin ( 4 ) and 2′‐demethyl‐3′‐ N ‐methylaplysinopsin 6 their 6‐bromo analogues in H Z / E ratio larger than 95:5; these mixtures undergo facile photoisomerization to give richer stereoisomer which thermal isomerization back original mixtures.
Infrared multiple-photon dissociation spectroscopy has been used to record vibrational spectra of charged copper-resveratrol complexes in the 3500–3700 cm−1 and 1100–1900 regions. Minimum energy structures have determined by density functional theory calculations using plane waves pseudopotentials. In particular, copper(I)-resveratrol complex presents a tetra-coordinated metal bound with two carbon atoms alkenyl moiety closest carbons adjoining resorcinol ring. For these geometries...
Encapsulation is a valuable strategy to protect and deliver anthocyanins (ACNs), phenolic compounds with outstanding antioxidant capacity but limited stability. In this study, coacervation was used encapsulate an ACN-rich red cabbage extract (RCE). Two agri-food by-product polymers, whey protein isolate (WPI) apple high-methoxyl pectin (HMP), were blended at pH 4.0 in specific ratio induce the formation of nanoparticles (NPs). The process optimisation yielded monodispersed population (PDI...
From the marine sponge Reniera sarai 3-alkylpyridinium oligomers and polymers have been isolated. 3-Alkylpyridinium are potent anticholinesterase agents; in addition, they show hemolytic cytotoxic activities. Oligomers with a molecular weight lower than 3000 Da do not possess any significant activity. We report structural characterization of their behavior aqueous solutions. found that biologically active composed head-to-tail units. According to MALDI-TOF spectrometry two species exist,...
Abstract It is shown that an unidentified nudibranch of Hawaiian waters contains a 26‐membered macrolide, sphinxolide ((−)‐ 1 ) with potent activity against the KB cell line. The structure sphinxolide, 2:1 mixture ( E / Z )‐isomers at formamide moiety, established to be (–)‐ on basis extensive NMR and FAB‐MS analysis, in combination data for products mono‐ (→(−)‐ 2 diacetylation (→(+)‐3).
Polyketide 13 [=2-hydroxy-5-((6-hydroxy-4-oxo-4H-pyran-2-yl)methyl)-2- propylchroman-4-one] and three related known compounds 7, 9 11 were obtained structurally characterized from Streptomyces sundarbansensis strain, an endophytic actinomycete isolated the Algerian marine brown algae Fucus sp. Compound was as major metabolite optimized culture conditions, by using Agar state fermentation. Due to tautomeric equilibrium, in CD3OD solution able incorporate five deuterium atoms, deduced NMR...
The design of materials capable mechanical responses to physical and chemical stimuli represents one the most exciting challenging areas scientific research because huge number their potential applications. This article is focused on molecular events occurring in thin films carboxylated nanocellulose fibers, which are converting water gradients into movements at macroscopic scale. analysis mechano‐actuation, conditions obtain it, shows that film movement fast reproducible, gradient intensity...
A bio-inspired multifunctionalized silk fibroin (BMS) was synthesized in order to mimic the interaction of nidogen with type IV collagen and laminin basement membranes. The designed BMS consists a motif α-chain-derived, called IK peptide, covalently bound (SF) by using EDC/NHS coupling Cu-free click chemistry reaction, respectively. Silk chosen as main component because it is versatile biocompatible, induces an vivo favorable bioresponse, moreover can be functionalized different methods....
Dimers and tetramers of linear 3-alkylpyridinium salts have been synthesized by an efficient synthetic pathway, which is also applicable to the preparation higher oligomers. Mono-, di- tetrameric compounds tested for antibacterial hemolytic activities inhibition acetylcholinesterase protein phosphatase 2A. Their were compared those natural poly-3-octylpyridinium alkaloids isolated from Mediterranean sponge Reniera sarai. Relatively high anti-acetylcholinesterase observed that increase with...
Abstract A mixture of sponges the East Pyrenean Mediterranean is shown to contain known sponge products longifolin ( 1 ), avarol ((+)‐ 3 and avarone 4 ) terrestrial‐plant product sesquirosefuran 2 besides new furano‐sesquiterpenoids tavacfuran (= 3‐methyl‐2‐[(3′ Z )‐3′‐methyl‐4″‐methyl‐2″‐furyl‐3′‐butenyl]furan; 5 tavacpallescensin 5,10‐dihydro‐6,9‐dimethyl‐4 H ‐benzo[5,6]cyclohepta[1,2‐ b ]furan; 6 furano‐butenolide sesquiterpenoids tavacbutenolide‐1 (±‐4‐ethoxy‐2‐methyl‐4‐)[(2′ E...
Reported here is the first polyarsenic compound ever found in nature. Denominated arsenicin A, it was isolated along a bioassay-guided fractionation of organic extract poecilosclerid sponge Echinochalina bargibanti collected from north-eastern coast New Caledonia. In defining an adamantine-type structure for this compound, deceptively simple NMR spectra were complemented by extensive mass spectral analysis. However, only synthesis model that provided basis to discriminate 4 other spectrally...