A5036621567- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Asymmetric Hydrogenation and Catalysis
- Sulfur-Based Synthesis Techniques
- CO2 Reduction Techniques and Catalysts
- Ammonia Synthesis and Nitrogen Reduction
- Carbon dioxide utilization in catalysis
- Catalytic Cross-Coupling Reactions
- Chemical Reactions and Isotopes
- Synthesis and Catalytic Reactions
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Innovative Microfluidic and Catalytic Techniques Innovation
- Oxidative Organic Chemistry Reactions
- Cyclopropane Reaction Mechanisms
- Catalytic Processes in Materials Science
- Chemical Synthesis and Reactions
Indian Institute of Technology Bombay
2020-2025
Chalcogenide motifs are present as principal moieties in a vast array of natural products and complex molecules. Till date, the construction these chalcogen has been restricted to either use directing groups or employment large excess electronically activated arenes, typically employed cosolvent. Despite being highly effective, methods have their own limitations step economy deployment an amount arenes. Herein, we report evolution catalytic system employing arene-limited, nondirected...
A mild metal-free approach for C(sp 3 )–H thioarylation of organic building blocks.
The Fujiwara–Moritani reaction using electric current is a powerful tool for the olefination of arenes by Pd-catalysed C–H activation.
Abstract Deuterated and tritiated analogs of drugs are valuable compounds for pharmaceutical medicinal chemistry. In this work, we present a novel hydrogen isotope exchange reaction using non‐directed homogeneous Pd‐catalysis. Aromatic C−H activation is achieved by commercially available pyridine ligand. Using the most convenient cheapest deuterium source, D 2 O, as only solvent 39 pharmaceuticals were labelled with clean profiles high uptakes. Additionally, describe first application...
Abstract Biaryl compounds are extremely important structural motifs in natural products, biologically active components and pharmaceuticals. Selective synthesis of biaryls by distinguishing the subtle reactivity difference distal arene C−H bonds significantly challenging. Herein, we describe para ‐selective arylation, which is acheived a unique combination meta ‐directing group norbornene as transient mediator. Upon direct ‐C−H palladation, one‐bond relay palladation occurs presence...
Abstract Biaryl compounds are extremely important structural motifs in natural products, biologically active components and pharmaceuticals. Selective synthesis of biaryls by distinguishing the subtle reactivity difference distal arene C−H bonds significantly challenging. Herein, we describe para ‐selective arylation, which is acheived a unique combination meta ‐directing group norbornene as transient mediator. Upon direct ‐C−H palladation, one‐bond relay palladation occurs presence...
CO 2 activation is one of the key steps towards mitigation. In this context, group 6 transition metal-based molecular catalysts can lead way.
A continuous photo-flow protocol for the anaerobic oxidative cleavage of styrenes using nitroarene as oxygen transfer reagent.
We herein report a novel Mn-SNS-based catalyst, which is capable of performing indirect hydrogenation CO2 to methanol via formylation. In this domain hydrogenation, pincer ligands have shown clear predominance. Our catalyst based on the SNS-type tridentate ligand, quite stable and cheap as compared type ligands. The can also be recycled effectively after formylation reaction without any significant change in efficiency. Various amines including both primary secondary worked well under...
Deuterated and tritiated analogs of drugs are valuable compounds for pharmaceutical medicinal chemistry. In this work, we present a novel hydrogen isotope exchange reaction using non-directed homogeneous Pd catalysis. Aromatic C–H activation is achieved by commercially available pyridine ligand. Using the most convenient cheapest deuterium source, D2O, as only solvent 34 pharmaceuticals were labelled with clean profiles high uptakes. Additionally, describe first application catalysis H/T on...
Abstract Deuterated and tritiated analogs of drugs are valuable compounds for pharmaceutical medicinal chemistry. In this work, we present a novel hydrogen isotope exchange reaction using non‐directed homogeneous Pd‐catalysis. Aromatic C−H activation is achieved by commercially available pyridine ligand. Using the most convenient cheapest deuterium source, D 2 O, as only solvent 39 pharmaceuticals were labelled with clean profiles high uptakes. Additionally, describe first application...
The Fujiwara-Moritani reaction is a powerful tool for the olefination of arenes by Pd-catalyzed C–H activation. However, need superstoichiometric amounts toxic chemical oxidants makes unattractive from an environmental and atom-economical view. Herein, we report first non-directed regioselective simple via electrooxidative reaction. versatility this operator-friendly approach was demonstrated broad substrate scope that includes arenes, heteroarenes variety olefins. Electroanalytic studies...
C-H thioarylation of hydrocarbon building blocks is a highly desirable synthetic transformation attributed to its prevalence in various pharmaceuticals and organic functional materials. However, all the developments till date majorly rely on peroxide mediated transformations. Unfortunately, harsh reaction conditions these reactions cause severe group intolerance. To surpass issues, photo-induced radical coupling have gained significant attention as sustainable way out, which require either...