A5058591435- Fibroblast Growth Factor Research
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Lipid metabolism and biosynthesis
- Metabolism and Genetic Disorders
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Eicosanoids and Hypertension Pharmacology
- Ion Transport and Channel Regulation
- Cholesterol and Lipid Metabolism
- Biomedical Research and Pathophysiology
Universitat de Barcelona
2012-2024
University Hospital Heidelberg
2021-2022
Heidelberg University
2021-2022
Institut des Maladies Génétiques Imagine
2019
Hôpital Necker-Enfants Malades
2019
Institut de Biomedicina de la Universitat de Barcelona
2012-2017
Institute for Research in Biomedicine
2016
Lipogenic gene expression in liver is repressed mice upon leucine deprivation. The hormone fibroblast growth factor 21 (FGF21), which critical to the adaptive metabolic response starvation, also induced under amino acid Upon deprivation, we found that FGF21 needed repress of lipogenic genes and white adipose tissue, stimulate phosphorylation hormone-sensitive lipase tissue. increased Ucp1 brown tissue these circumstances impaired FGF21-deficient mice. Our results demonstrate important role...
In diabetic patients, dyslipidemia frequently contributes to organ damage such as kidney disease (DKD). Dyslipidemia is associated with both excessive deposition of triacylglycerol (TAG) in lipid droplets (LDs) and lipotoxicity. Yet, it unclear how these two effects correlate each other the they are influenced by dietary patterns. By using a diabetes mouse model, we find here that high-fat diet enriched monounsaturated oleic acid (OA) caused more storage LDs renal proximal tubular cells...
Scope Fibroblast growth factor 21 (FGF21) is considered a promising therapeutic candidate for the treatment of obesity. Since FGF21 production regulated by various nutritional factors, we analyze impact low protein intake on circulating levels this hormone in mice and sub cohort PREDIMED ( Prevención con Dieta Mediterránea ) trial. We also describe role hepatic metabolic adaptation to low‐protein diet (LPD). Methods results fed control liver‐specific Fgf21 knockout (L KO) LPD. This increased...
HNF4A is a nuclear hormone receptor that binds DNA as an obligate homodimer. While all known human heterozygous mutations are associated with the autosomal-dominant diabetes form MODY1, one particular mutation (p.R85W) in DNA-binding domain (DBD) causes additional renal Fanconi syndrome (FRTS). Here, we find expression of conserved fly ortholog dHNF4 harboring FRTS Drosophila nephrocytes caused depletion and cytosolic aggregation wild-type reporter protein. led to mitochondrial defects lipid...
Scope The rosehip ( Rosa canina ) is a perennial shrub with reddish pseudofruit that has demonstrated antidiabetic, antiatherosclerotic, and antiobesogenic effects in rodent models but there low information about the molecular mechanisms underlying these on onset progression of diet‐induced obesity. Methods results Four‐week‐old C57BL/6J male mice are subjected to high‐fat diet (HFD)‐supplemented or not R. flesh for 18 weeks. indicated exerts preventive effect HFD‐induced obesity significant...
Abstract In diabetic patients, dyslipidemia frequently contributes to organ damage such as kidney disease (DKD). DKD is associated with excessive renal deposition of triacylglycerol (TAG) in lipid droplets (LD). Yet, it unclear whether LDs play a protective or damaging role and how this might be influenced by dietary patterns. By using diabetes mouse model, we find here that high fat diet enriched the unsaturated oleic acid (OA) caused more storage proximal tubular cells (PTC) but less than...