A5058824970- Child Nutrition and Water Access
- Iron Metabolism and Disorders
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Antioxidant Activity and Oxidative Stress
- Connective tissue disorders research
- Folate and B Vitamins Research
- Hemoglobinopathies and Related Disorders
- Infant Nutrition and Health
- Retinoids in leukemia and cellular processes
- Food Security and Health in Diverse Populations
- Gestational Diabetes Research and Management
- Child Nutrition and Feeding Issues
- Global Maternal and Child Health
- Nutritional Studies and Diet
- Vitamin C and Antioxidants Research
- Obesity, Physical Activity, Diet
- Neonatal Health and Biochemistry
- Trace Elements in Health
- Thyroid Disorders and Treatments
- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- Growth Hormone and Insulin-like Growth Factors
- Cystic Fibrosis Research Advances
- Arsenic contamination and mitigation
Johns Hopkins University
2016-2025
Instituto Nacional do Semiárido
2019
Universidade Federal do Ceará
2019
Bloomberg (United States)
2014-2016
National Institutes of Health
2015
Child Health Research Foundation
2015
Mahidol University
2014
Marienhospital Osnabrück
2010
Cambridge University Press
2010
New York University Press
2010
Maternal micronutrient deficiencies may adversely affect fetal and infant health, yet there is insufficient evidence of effects on these outcomes to guide antenatal supplementation in South Asia.To assess multiple vs iron-folic acid 6-month mortality adverse birth outcomes.Cluster randomized, double-masked trial Bangladesh, with pregnancy surveillance starting December 4, 2007, recruitment January 11, 2008. Six-month follow-up ended August 30, 2012. Surveillance included 127,282 women;...
Maternal vitamin A deficiency is a public health concern in the developing world. Its prevention may improve maternal and infant survival.To assess efficacy of or beta carotene supplementation reducing pregnancy-related mortality.Cluster randomized, double-masked, placebo-controlled trial among pregnant women 13 to 45 years age their live-born infants 12 weeks (84 days) postpartum rural northern Bangladesh between 2001 2007. Interventions Five hundred ninety-six community clusters (study...
Background: Growth faltering in the first 2 years of life is high South Asia where prevalence stunting estimated at 40–50%. Although nutrition counselling has shown modest benefits, few intervention trials food supplementation exist showing improvements growth and prevention stunting. Methods: A cluster-randomized controlled trial was conducted rural Bangladesh to test effect two local, ready-to-use foods (chickpea rice-lentil based) a fortified blended (wheat-soy-blend++, WSB++) compared...
Isobaric tags for relative and absolute quantitation (iTRAQ) is a prominent mass spectrometry technology protein identification quantification that capable of analyzing multiple samples in single experiment. Frequently, iTRAQ experiments are carried out using an aliquot from pool all samples, or "masterpool", one the channels as reference sample standard to estimate abundances biological combine abundance estimates experiments. In this manuscript, we show masterpool counterproductive. We...
Antenatal multiple micronutrient (MM) supplementation improves birth outcomes relative to iron–folic acid (IFA) in developing countries, but limited data exist on its impact pregnancy status. We assessed the efficacy of a daily MM (15 nutrients) compared with IFA supplement, each providing approximately 1 RDA nutrients and given beginning at ascertainment, late status women rural Bangladesh. Secondarily, we explored other contributors Within double-masked trial (JiVitA-3) among 44,500...
Iron deficiency remains the most prevalent form of human malnutrition, and current interventions to control it have not decreased global prevalence. Hookworm activities are becoming more widely implemented, but importance these efforts prevent anemia in populations is well-defined. We studied relationships among hookworm infection, intestinal blood loss, iron status 203 Zanzibari school children. Helminth infection intensity was quantified by fecal egg counts, defined low hemoglobin serum...
We present the design, methods and population characteristics of a large community trial that assessed efficacy weekly supplement containing vitamin A or beta-carotene, at recommended dietary levels, in reducing maternal mortality from early gestation through 12 weeks postpartum. identify challenges faced report solutions implementing an intervention under low-resource, rural conditions, including importance choice promoting generalizability, maintaining rigorous data quality control to...
PurposeAchondroplasia is the most common short stature skeletal dysplasia (1:20,000–30,000), but risk of adverse health outcomes from cardiovascular diseases, pain, poor function, excess weight, and sleep apnea unclear. A multicenter retrospective natural history study was conducted to understand medical surgical practices in achondroplasia.MethodsData patients with achondroplasia evaluated by clinical geneticists at Johns Hopkins University, A.I. duPont Hospital for Children, McGovern...
Environmental enteric dysfunction (EED) may inhibit growth and development in low- middle-income countries, but available assessment methodologies limit its study. In rural Bangladesh, we measured EED using the widely used lactulose mannitol ratio (L:M) test a panel of intestinal systemic health biomarkers to evaluate convergence among describe risk factors for EED.In 539 18-month-old children finishing participation randomized food supplementation trial, serum, stool, urine collected after...
The height-for-age (HA) reference currently used for children with achondroplasia is not adaptable electronic records or calculation of HA Z-scores. We report new curves and tables mean standard deviation (SD) HA, calculating Z-scores, from birth-16 years in achondroplasia. Mixed longitudinal data were abstracted medical patients a single clinical practice (CIS, 1967-2004). Gender-specific height percentiles (5, 25, 50, 75, 95th) estimated across the age continuum, using 2 month window per...
Achondroplasia is the most common genetic skeletal disorder causing disproportionate short stature/dwarfism. Common additional features include spinal stenosis, midface retrusion, macrocephaly and a generalized spondylometaphyseal dysplasia which manifest as cord compression, sleep disordered breathing, delayed motor skill acquisition genu varus with musculoskeletal pain. To better understand interactions health outcomes of these potential complications, we embarked on multi-center, natural...