A5101608626- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Bioactive Compounds
- Healthcare and Venom Research
- Metabolomics and Mass Spectrometry Studies
- Fungal Biology and Applications
- Plant-based Medicinal Research
- Biochemical Acid Research Studies
- Tryptophan and brain disorders
- Computational Drug Discovery Methods
- Andrographolide Research and Applications
Chinese PLA General Hospital
2022-2025
Nanchang University
2021
First Affiliated Hospital of Nanchang University
2021
Anhui University of Traditional Chinese Medicine
2014
Tianjin University of Traditional Chinese Medicine
2013
Objective: Colorectal Cancer (CRC) has attracted much attention due to its high mortality and morbidity. Cordycepin, also known as 3'-deoxyadenosine (3'-dA), exhibits many biological functions, including antibacterial, anti-inflammatory, antiviral, anti-tumor, immunomodulatory effects. It been proven show anticancer activity in both laboratory research studies living organisms. However, the molecular mechanism of effect cordycepin on CRC remains unclear. Methods: The genes associated with...
BanXia-YiYiRen (Pinellia Ternata and Coix Seed, BX-YYR) has been clinically proven to be an effective Chinese medicine compatible with the treatment of insomnia. However, underlying mechanism BX-YYR against insomnia remains unclear. This study aimed explore pharmacological mechanisms in treating based on network pharmacology experimental validation. The drug-disease targets were obtained using publicly available databases. analysis revealed 21 active compounds 101 potential from database...
Yuanhu Zhitong prescription (YZP) is a typical and relatively simple traditional Chinese medicine (TCM), widely used in the clinical treatment of headache, gastralgia, dysmenorrhea. However, underlying molecular mechanism action YZP not clear. In this study, based on previous chemical metabolite analysis, complex approach including prediction structure metabolite, high-throughput silico screening, network reconstruction analysis was developed to obtain computational drug-target for YZP. This...
Objective To evaluate the effect of lappaconitine on renal ischemia-reperfusion (I/R) injury in mice. Methods Thirty-six male Wistar rats, weighing 180-220 g, were randomly divided into 3 groups (n=12 each) using a random number table: sham operation group (group S), I/R and LA). Renal was induced by occlusion left pedicle for 45 min with atraumatic microclips followed reperfusion, right kidney removed after released.At 30 before 4 mg/kg injected intraperitoneally LA, normal saline 2...
Abstract Huanglian jiedu decoction (HLJDD) is a heat-clearing and detoxifying agent composed of four kinds Chinese herbal medicine. Previous studies have shown that HLJDD can improve the inflammatory response ulcerative colitis (UC) maintain intestinal barrier function. However, its molecular mechanism not completely clear. In this study, we verified bioactive components (BCI) potential targets in treatment UC by means network pharmacology docking, constructed pharmacological PPI network....