A5034932588- Pharmacogenetics and Drug Metabolism
- Protein purification and stability
- Flood Risk Assessment and Management
- Graphene and Nanomaterials Applications
- Urban and Rural Development Challenges
- Infectious Diseases and Tuberculosis
- Orthopedic Infections and Treatments
- Advanced Polymer Synthesis and Characterization
- Synthesis and Biological Evaluation
- Cancer Treatment and Pharmacology
- Orthopaedic implants and arthroplasty
- Surfactants and Colloidal Systems
- Synthesis and biological activity
- Computational Drug Discovery Methods
- Drug Solubulity and Delivery Systems
- Polymer Nanocomposites and Properties
- Soil erosion and sediment transport
University of Michigan
2019-2021
Ann Arbor Center for Independent Living
2019
Xavier University of Louisiana
2014-2015
University of Education, Winneba
2012
In humans, cytochrome P450 1A2 is the major enzyme metabolizing environmental arylamines or heterocyclic amines into carcinogens. Since evidence shows that planar triangle-shaped molecules are capable of selectively inhibiting 1A2, 16 triangular flavone, and coumarin derivatives were designed synthesized for these studies. Among compounds, 7,8-furanoflavone time-dependently inhibits with a KI value 0.44 μM. With 5 min preincubation in presence NADPH, 0.01 μM completely inactivates but does...
The flavone backbone is a well-known pharmacophore present in number of substrates and inhibitors various P450 enzymes. In order to find highly potent novel family I enzyme inhibitors, an acetylene group was incorporated into six different positions flavone. introduction at certain locations the lead time-dependent 1A1. 3'-Ethynylflavone, 4'-ethynylflavone, 6-ethynylflavone, 7-ethynylflavone (KI values 0.035-0.056 μM) show strong inhibition 1A1, while 5-ethynylflavone value 0.51 moderate...
Aqueous solutions of polyethylene oxide–polypropylene oxide–polyethylene oxide (PEO–PPO–PEO) copolymers form micelles and cubic lattices as their temperature is raised.
Soil erosion studies around houses in four communities Ghana were carried out from August to November, 2010. Thirty selected each of the for study. Measurements slope and depth exposed foundation done with help a string tape measure. Data also obtained through questionnaire interview house owners. The Pearson’s correlation coefficient was used measure some relationships among data. In selection site building house, higher percentage owners considered no factor. major cleaning activity...