Shihan Zhen

ORCID: 0000-0003-3248-2684
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Research Areas
  • Obesity, Physical Activity, Diet
  • Nutritional Studies and Diet
  • Air Quality and Health Impacts
  • Liver Disease Diagnosis and Treatment
  • Diet, Metabolism, and Disease
  • Energy and Environment Impacts
  • Climate Change and Health Impacts
  • Galectins and Cancer Biology
  • Birth, Development, and Health
  • HIV/AIDS Research and Interventions
  • Eating Disorders and Behaviors
  • Adolescent Sexual and Reproductive Health
  • Liver Disease and Transplantation
  • Complement system in diseases
  • Attention Deficit Hyperactivity Disorder
  • Colorectal and Anal Carcinomas
  • HIV, Drug Use, Sexual Risk
  • Biomarkers in Disease Mechanisms
  • Adipokines, Inflammation, and Metabolic Diseases
  • Exercise and Physiological Responses
  • Mobile Health and mHealth Applications
  • Artificial Intelligence in Healthcare and Education
  • Cancer Risks and Factors
  • Telomeres, Telomerase, and Senescence
  • Bone health and osteoporosis research

Southern University of Science and Technology
2023-2025

China Medical University
2017-2023

Associations of dietary patterns in Chinese adolescents and children with later obesity have not previously been investigated. The purpose the present study was to evaluate associations between risk by using a longitudinal design. Data from China Health Nutrition Survey (CHNS), nationally representative survey, were used for our analysis. 489 participants 6–14 years age followed 2006 2011. Factor analysis identify children. Ordered logistic regression models examine association obesity. Two...

10.1186/s12937-018-0372-8 article EN cc-by Nutrition Journal 2018-07-11

In recent years, with the rapid development of deep learning, artificial intelligence (AI) has gradually become a powerful assistant for humans in various aspects. The maturity and advancement natural language models led to birth Chat Generative Pre-Trained Transformer (ChatGPT), generating great potential healthcare applications. This review summarized possible application prospects ChatGPT healthcare, assessed limitations that still exist, suggested improvements. conclusion, current...

10.1016/j.gande.2023.07.002 article EN cc-by-nc-nd Gastroenterology & Endoscopy 2023-07-01

Most studies related to food addiction have focused on assessing among adult populations. However, evidence in adolescents has been limited. The aim of this study was investigate the prevalence a non-clinical adolescent sample. Psychosocial correlations and associations with different quality life dimensions were also tested.The sample included 593 Chinese (51.9% female; age range: 13⁻17 years). All participants provided sociodemographic information completed questionnaires regarding...

10.3390/nu10070837 article EN Nutrients 2018-06-28

Prehypertension and hypertension often coexist with non-alcoholic fatty liver disease (NAFLD) during the progression of cardiovascular (CVD). International academic societies have recently reached a consensus to replace NAFLD new term 'steatotic disease' (SLD). In this study, we aimed evaluate impact different SLD subtypes on all-cause CVD mortality in individuals prehypertension or hypertension. We included 6074 adults from National Health Nutrition Examination Survey (2003-18). The US...

10.7189/jogh.15.04003 article EN cc-by Journal of Global Health 2025-01-16

Abstract Background Limited evidence exists for the association between dietary patterns and later obesity phenotypes among Chinese adults. This longitudinal study aimed to evaluate associations of with general central in Methods Based on China Health Nutrition Survey (CHNS) waves 2004 2015, was conducted 4207 adult men women (age range: 18–65 years). Dietary intakes were assessed by three consecutive 24-h recalls, identified using exploratory factor analysis. Longitudinal evaluated logistic...

10.1186/s12889-023-16556-0 article EN cc-by BMC Public Health 2023-08-21

Cardiometabolic diseases (CMDs) are the major types of non-communicable diseases, contributing to huge disease burdens in Western Pacific region (WPR). The use digital health (dHealth) technologies, such as wearable gadgets, mobile apps, and artificial intelligence (AI), facilitates interventions for CMDs prevention treatment. Currently, most studies on dHealth WPR were conducted a few high- middle-income countries like Australia, China, Japan, Republic Korea, New Zealand. Evidence indicated...

10.1016/j.lanwpc.2023.100817 article EN cc-by-nc-nd The Lancet Regional Health - Western Pacific 2023-12-01

MicroRNAs (miRNAs) are known to be associated with certain cancers, including osteosarcoma. We examined osteosarcoma tissues and cell lines, found that most expressed lower levels of miR-548d-3p than adjacent normal lines. KRAS was identified as a potential target gene miR-548d-3p. In cells, exerted tumor-suppressive effects by downregulating KRAS. Functional assays revealed mimics dramatically reduced growth migration in vitro. These results suggest could applied for treatment.

10.18632/aging.102097 article EN cc-by Aging 2019-07-21

Purpose: To determine the plasma concentrations of butyrylcholinesterase (BChE), also known as pseudocholinesterase, in different weight categories adolescents, and to explore possible association between BChE overweight (OW), obesity, metabolic syndrome (MetS) Chinese adolescents. Patients methods: This cross-sectional study included 1,236 adolescents (194 obese [OB], 188 OW, 732 normal [NW], 122 underweight [UW]). The biochemical variables anthropometric participants were evaluated. Plasma...

10.2147/dmso.s201594 article EN cc-by-nc Diabetes Metabolic Syndrome and Obesity 2019-05-01

Background: Solidarity, such as community connectedness and social cohesion, may be useful in improving HIV testing uptake among men who have sex with (MSM). This study aimed to evaluate the impact of solidarity on before coronavirus disease 2019 (COVID-19) willingness during COVID-19 MSM China. Materials Methods: An online survey was conducted collect sociodemographic, sexual behavioral, items' information from participants. We first used factor analysis reveal principal component items...

10.3389/fpubh.2021.752965 article EN cc-by Frontiers in Public Health 2021-12-09

Importance Understanding the outcomes of artificial light at night (ALAN) on insomnia is crucial for public health, particularly in rapidly urbanizing regions. However, evidence association between ALAN exposure and limited, despite large number people exposed to ALAN. Objective To explore outdoor among Chinese population. Design, Setting, Participants This cross-sectional study used social media data from Weibo (Sina), a platform, satellite-derived nighttime images. The period spans May...

10.1001/jamanetworkopen.2024.46156 article EN cc-by-nc-nd JAMA Network Open 2024-11-20

Background The aims of this study were to determine the association between sibling rank and childhood obesity among children ≤ 5 years age in rural China, investigate effect child gender status other siblings on association. Methods Data from China Family Panel Studies, a nationally representative survey, was used for analysis. Sibling defined as birth order all with same biological mother. A total 1116 divided into four groups: without siblings, first-born children, second-born third-born...

10.1371/journal.pone.0187693 article EN cc-by PLoS ONE 2017-11-27

Childhood obesity (OB) and metabolic syndrome (MetS) have become a worldwide health problem. Comparative proteomic approaches are widely used in human OB to analyze protein changes blood plasma. The present study determined the galectin-3 binding (galectin-3BP) expression level different weight categories assessed associations between galectin-3BP MetS.The current included 932 Chinese adolescents 13-18 years of age. biochemical anthropometric variables all subjects were evaluated using...

10.1136/bmjdrc-2020-001894 article EN cc-by-nc BMJ Open Diabetes Research & Care 2021-04-01

Background Galectin-3-binding protein (GAL-3BP) is a ubiquitous and multifunctional secreted glycoprotein, which functions in innate immunity has been highlighted as potential mediator of adipose inflammation obesity. In this study, we aimed to identify whether GAL-3BP novel biological marker for metabolic syndrome (MetS). Methods The biochemical anthropometric variables the 570 participants study were evaluated using standard procedures. Their serum levels measured enzyme-linked...

10.3389/fendo.2021.726154 article EN cc-by Frontiers in Endocrinology 2021-11-10

Shift work has become an increasingly common mode globally. This study aimed to investigate the association between shift and risk of incident gastroesophageal reflux disease (GORD), upward gastrointestinal disorder worldwide, explore mediating factors.A total 262,722 participants from UK Biobank free GORD related diseases were included potential mediators GORD. Multivariate-adjusted Cox models used evaluate status incidence.Compared non-shift workers, workers had a 1.10-fold greater [95%...

10.3389/fpubh.2023.1192517 article EN cc-by Frontiers in Public Health 2023-08-24

<title>Abstract</title> <bold>Background</bold> Growing evidence suggest that ethylene oxide (EO) may have deleterious effects on health conditions, but the relationship between EO and adulthood nonalcoholic fatty liver disease (NAFLD) remains vague. Our objective is to evaluate whether exposure would influence prevalence of NAFLD in a nationally cross-sectional study. <bold>Materials methods </bold>In this study, We analyzed 2,394 participants from National Health Nutrition Examination...

10.21203/rs.3.rs-3300124/v2 preprint EN cc-by Research Square (Research Square) 2024-05-16

Background Complement C1q (C1q) has been confirmed to be related obesity, metabolic syndrome (MetS), and its components. However, human data regarding the associations are relatively scarce. This study aimed investigate of with obesity as well MetS in Chinese adolescents. Methods A total 1,191 adolescents aged 13–18 years were enrolled this study. The biochemical anthropometric variables all subjects evaluated using standardized procedures. was measured immunoturbidometric assay....

10.3389/fendo.2020.586440 article EN cc-by Frontiers in Endocrinology 2020-11-30

This study aims to explore the longitudinal relationship between solid fuel use and CMD incidence based on a nationally representative follow-up cohort study. A total of 6038 participants China Health Retirement Longitudinal Study (CHARLS) were enrolled in is cluster diseases that include heart disease, stroke, type 2 diabetes. Cox proportional-hazards regression models used examine association or multimorbidity CMD. The interactions overweight obesity household air pollution also...

10.3390/ijerph20042826 article EN International Journal of Environmental Research and Public Health 2023-02-05

<title>Abstract</title> <bold>Background: </bold>Growing evidence suggest that ethylene oxide (EO) may have deleterious effects on health conditions, but the relationship between EO and adulthood nonalcoholic fatty liver disease (NAFLD) remains vague. Our objective is to evaluate whether exposure would influence risk of NAFLD in a nationally cross-sectional study. <bold>Method: </bold>In this study, We analyzed 2709 participants from National Health Nutrition Examination Survey (NHANES)...

10.21203/rs.3.rs-3300124/v1 preprint EN cc-by Research Square (Research Square) 2023-09-29

Dietary surveyis a method to evaluate whether dietary intake meets body requirements by recording food consumed during certain period. Widely-used survey methods include: 24 h recall, record, frequency questionnaire and history questionnaire. Since each has its own advantages limitations, researchers need choose appropriate according research purposes, accuracy requirements, availability of resources, etc. Obese children who are the focus major difficulty in survey, it is important an...

10.3760/cma.j.issn.1674-0815.2017.02.018 article EN Chin J Health Manage 2017-04-20
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