A5056297666- Autophagy in Disease and Therapy
- Toxoplasma gondii Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver physiology and pathology
- Calcium signaling and nucleotide metabolism
- RNA and protein synthesis mechanisms
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Click Chemistry and Applications
- Mosquito-borne diseases and control
- Pancreatic and Hepatic Oncology Research
- Drug Transport and Resistance Mechanisms
- Chemical Synthesis and Analysis
- Retinoids in leukemia and cellular processes
Genoscience Pharma (France)
2019-2022
University of Bologna
1996
Hepatocellular carcinoma is the most frequent primary liver cancer. Macroautophagy/autophagy inhibitors have been extensively studied in cancer but, to date, none has reached efficacy clinical trials. In this study, we demonstrated that GNS561, a new autophagy inhibitor, whose anticancer activity was previously linked lysosomal cell death, displayed high tropism and potent antitumor against panel of human lines two hepatocellular vivo models. We showed due its lysosomotropic properties,...
Since December 2019, SARS-CoV-2 has spread quickly worldwide, leading to more than 280 million confirmed cases, including over 5,000,000 deaths. Interestingly, coronaviruses were found subvert and hijack autophagic process allow their viral replication. Autophagy-modulating compounds thus rapidly emerged as an attractive strategy fight infection, the well-known chloroquine (CQ). Here, we investigated antiviral activity associated mechanism of GNS561/Ezurpimtrostat, a small lysosomotropic...
Hepatic fibrosis is the result of chronic liver injury that can progress to cirrhosis and lead failure. Nevertheless, there are no anti-fibrotic drugs licensed for human use. Here, we investigated activity GNS561, a new lysosomotropic molecule with high tropism.The effect GNS561 was determined in vitro using LX-2 hepatic stellate cells (HSCs) primary HSCs by studying cell viability, caspases 3/7, autophagic flux, cathepsin maturation activity, HSC activation transforming growth factor-β1...
Abstract Background & Aims Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer. Autophagy inhibitors have been extensively studied in cancer but, to date, none has reached efficacy clinical trials. Approach Results To explore antitumor effects of GNS561, a new autophagy inhibitor, we first achieved vitro assays using various human cell lines. Having demonstrated that GNS561 displayed high tropism mass spectrometry imaging, potency on tumor was evaluated vivo two HCC...
Conference Abstract| November 01 1996 APOPTOSIS INDUCED BY 9-, 10-OH STEARIC ACIDS IN HUMAN HT29 ADENOCARCINOMA CELLS N. Gesmundo; Gesmundo 1Dept. Biochem., University of Bologna. Via Irnerio 48, Bologna, Italy Search for other works by this author on: This Site PubMed Google Scholar E. Casali; Casali °Inst. Biol. Chem., Parma, Gramsci 14, C. Boga; Boga *Dept. Org. Viale Risorgimento 4, G. Farruggia; Farruggia M. Novello; Novello S. Zanna; Zanna L. Masotti Biochem Soc Trans (1996) 24 (4):...