A5041625172- Polymer composites and self-healing
- Mast cells and histamine
- Diet, Metabolism, and Disease
- Pharmacological Effects of Natural Compounds
- Allergic Rhinitis and Sensitization
- Advanced biosensing and bioanalysis techniques
- Liver Disease Diagnosis and Treatment
- Polymer Nanocomposites and Properties
- Biosensors and Analytical Detection
- Plant-Derived Bioactive Compounds
- Natural Antidiabetic Agents Studies
- Endoplasmic Reticulum Stress and Disease
- Urticaria and Related Conditions
- Medicinal Plants and Neuroprotection
- Animal Virus Infections Studies
- Phytochemistry and biological activity of medicinal plants
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Cholinesterase and Neurodegenerative Diseases
- Electrochemical sensors and biosensors
- Nigella sativa pharmacological applications
- Flavonoids in Medical Research
- Environmental Engineering and Cultural Studies
- Tea Polyphenols and Effects
- Phytochemical compounds biological activities
National Nuclear Energy Agency of Indonesia
2025
National Research and Innovation Agency
2022-2024
Korea Institute of Science and Technology
2015-2022
Indonesian Institute of Sciences
2010-2021
Diponegoro University
2019
Korea University of Science and Technology
2016
University of Indonesia
2014
Burn is a major skin injury that occurs worldwide. For second-degree burns, special treatment should be given for creating suitable wound healing environment. Hydrogel dressing as the primary care possess extra properties include antibacterial activity and cytocompatibility to enhance effectiveness. Additional therapy such electrical stimulation can applied well promote healing. Herein, we used tissue engineering concept create novel cytocompatible hydrogel made of polyvinyl alcohol (PVA),...
Nonalcoholic fatty liver diseases (NAFLD) range histopathologically from hepatic steatosis to steatohepatitis. Chicoric acid has beneficial effects on obesity and injury, but its nonalcoholic steatohepatitis (NASH) have not yet been determined. This study examined the of Crepidiastrum denticulatum extract (CDE) active compound chicoric in a mouse model NASH fibrosis.CDE were orally administrated mice fed methionine- choline-deficient (MCD) diet. HepG2 AML-12 cells MCD medium incubated with...
Abstract Stellera chamaejasme L. (Thymelaeaceae) is a perennial herb that widely used in traditional Chinese medicine to treat tumours, tuberculosis and psoriasis. S. extract (SCE) possesses anti-inflammatory, analgesic wound healing activities; however, the effect of its active compounds on cutaneous has not been investigated. We assessed full-thickness wounds Sprague-Dawley (SD) rats topically applied SCE for 2 weeks. In vitro studies were performed using HaCaT keratinocytes, Hs68 dermal...
Abstract Objectives Here, we hypothesized that Hovenia dulcis branch extract (HDB) and its active constituents ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis (AD)-like skin lesions by modulating the T helper Th1/Th2 balance in NC/Nga mice TNF-α- IFN-γ-induced production of thymus activation-regulated chemokine (TARC) macrophage-derived (MDC) HaCaT cells. Methods cells were stimulated TNF-α/IFN-γ presence HDB constituents. TARC MDC measured ELISA RT-PCR. For in-vivo study,...
Context: The hepatoprotective activity of Centella asiatica is very well described. However, it often administered to the animals before prominent damage liver occurs. Aims: To evaluate spray-dried ethanol extract (CSD) after damage. Methods: Sprague-Dawley rats (n = 56) were divided into 7 groups, i.e., normal control, negative positive comparative low dose CSD, medium and high CSD. A combination Gal 300 mg/kg LPS 10 μg/kg was used induce acute injury/hepatitis. Methylprednisolone (50...
Nonalcoholic fatty liver disease (NAFLD) ranges in severity from hepatic steatosis to cirrhosis. Lemon balm and its major constituent, rosmarinic acid (RA), effectively improve the injury obesity; however, their therapeutic effects on nonalcoholic steatohepatitis (NASH) are unknown. In this study, we investigated of RA a lemon extract (LBE) NAFLD fibrosis elucidated mechanisms. Palmitic (PA)-exposed HepG2 cells db/db mice fed methionine- choline-deficient (MCD) diet were utilized exhibit...
<italic>Hovenia dulcis</italic>Thunb. is a hardy tree native to Europe, the Middle East, and North Africa, it also grown in parts of Asia has been used traditional medicine treat liver toxicity, stomach disorders, inflammation.
Abstract Background Dopamine is an important catecholamine neurotransmitter that plays a critical function as chemical messenger aids in the signal transmission brain and other places. known to play role several neurological diseases such schizophrenia Parkinson's disease which key factor development of abnormally lower levels dopamine compared normal levels. However, these methods are expensive, requires manual labor resources, demands large number reagents chemicals. Therefore, it...
In this study, multifunctional chitosan-pluronic F127 with magnetic reduced graphene oxide (MRGO) nanocomposites were developed through the immobilization of chitosan and an amphiphilic polymer (pluronic F127) onto MRGO. Physicochemical characterizations in-vitro cytotoxicity investigated field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, particle size analysis, vibrating sample magnetometer, Raman spectroscopy...
Candida Antarctica Lipase B (CALB) is extensively studied in enzymatic production of biodiesel, pharmaceutical products, detergents and other chemicals. One drawback using CALB its relatively low optimum temperature at 313 K (40°C). The objective this research to design mutant with improved thermostability by introducing extra disulfide bond. Molecular dynamic simulation was conducted get better insight into the process thermal denaturation or unfolding CALB. Thermal accelerated conducting...
This work describes for the first time surface modification of natural-based fluorescent nanoparticles with antibodies as optical biosensing platforms.
Propionibacterium acnes and Staphylococcus epidermidis are Gram-positive commensal bacteria on human skin that can turn opportunistic. In a previous study, Cassia alata L. leaves extract had shown antibacterial activity against bacteria. this C. is used as an active ingredient in topical cream preparation. This study aimed to determine the stability of P. S. epidermidis. We prepared containing 1.25%, 2.5%, 5% evaluated their physical parameters. The good characteristics, but there were...
Ethnobotanically in Indonesia, Diospyros celebica Bakh is recognized as having antidiabetic activity. This study aimed to isolate compounds from the leaves of Eboni (Diospyros celebica). D. were dried and extracted with 96% ethanol, then fractionated purified guided by antioxidant activity test, α-glucosidase inhibitory dipeptidyl peptidase-4 (DPP-4) test until bioactive isolates obtained. The identified their structures determined based on NMR 1H, 13C, 2D, LCMS/MS spectroscopic data....
Probiotics are beneficial live microorganisms because they provide health benefits to the host after being consumed in sufficient amounts, primarily by increasing proliferation of native digestive microflora. Hypercholesterolemia is a condition which cholesterol serum concentration elevated significantly (exceeds 200 mg/dL). characterized high plasma levels low-density lipoprotein (LDL) and low high-density (HDL). This review aims examine mechanism action probiotics preventing risk...
Centella asiatica accumulates large quantities of pentacyclic triterpenoid saponins, collectively known as centelloids. These terpenoids include asiaticoside, centelloside, madecassoside, brahmoside, brahminoside, thankuniside, sceffoleoside, centellose, asiatic-, brahmic-, centellic- and madecassic acids. Preparations C. are used in traditional alternative medicine due to the wide spectrum pharmacological activities associated with these secondary metabolites, such anticellulite agent....
Abstract The increasing customer awareness and supporting regulation on environmentally-friendly products around the globe has fostered need for revealing environmental performance information their label, using an instrument called ecolabel. Ecolabeling system requires a life cycle consideration product, Life Cycle Assessment (LCA) serves as method to perform assessment entire product’s cycle. In field of food industry, specifically tea 2014 report by International Institute Sustainable...
Research to explore consumer perspective toward tea product requirements has been being emphasized around the globe, as well advancing variety of demand and market competitiveness. Particularly in Indonesia, broader needs government relevant policies environmental consideration made these issues also need be significantly addressed. This study aimed analyze consumption patterns Indonesia support diversified sustainable products. T he research design was conducted using survey method. A...
Paederia foetida Linn. is a rich source of active compounds, yet its antioxidant and cytotoxic properties remain poorly studied. This current research aimed to investigate the chemical profiles crude extract derived from P. leaves, fractionated substances, their on MCF-7 cells, breast carcinoma cell. Six substances have been separated in thin layer chromatography (TLC) plate. Five fractions showed properties, as indicated by formation yellowish band TLC plate after spraying with DPPH...