A5082455443- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Pharmacogenetics and Drug Metabolism
- Neurobiology and Insect Physiology Research
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Cancer-related molecular mechanisms research
- Synthesis and Characterization of Pyrroles
- Estrogen and related hormone effects
- Cancer Mechanisms and Therapy
- Metabolomics and Mass Spectrometry Studies
- Peptidase Inhibition and Analysis
- Bioinformatics and Genomic Networks
- Cytokine Signaling Pathways and Interactions
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- Renin-Angiotensin System Studies
Hanyang University
2023-2024
Anyang University
2023
Matrix Research (United States)
2023
University of Washington
2023
Jeju National University
2020-2022
Saturated fatty acids possess few health benefits compared to unsaturated acids. However, increasing experimental evidence demonstrates the nutritionally beneficial role of odd-chain saturated in human health. In this study, anti-cancer effects pentadecanoic acid were evaluated breast carcinoma MCF-7/stem-like cells (SC), a cell line with greater mobility, invasiveness, and cancer stem properties parental MCF-7 cells. Pentadecanoic exerted selective cytotoxic MCF-7/SC Moreover, reduced...
Estrogen receptors are indicators of breast cancer adaptability to endocrine therapies, such as tamoxifen. Deficiency or absence estrogen receptor α (ER-α) in cells results reduced efficacy therapy. Here, we investigated the effect combined tamoxifen and pentadecanoic acid therapy on ER-α-under-expressing cells. Drug resistance gene expression patterns were determined by RNA sequencing analysis vitro experiments. For first time, demonstrate that treatment acid, an odd-chain fatty...
Targeting cancer stem cell metabolism has emerged as a promising therapeutic strategy for treatment. Breast cells (BCSCs) exert distinct machinery, which plays major role in radiation and multidrug resistance. Therefore, exploring the mechanisms involved energy utilization of BCSCs could improve effectiveness strategies aimed at their elimination. This study was conducted to clarify glucose machinery function nootkatone, bioactive component grapefruit, regulating stemness characteristics...
The α-arrestins form a large family of evolutionally conserved modulators that control diverse signaling pathways, including both G-protein-coupled receptor (GPCR)-mediated and non-GPCR-mediated across eukaryotes. However, unlike β-arrestins, only few α-arrestin targets functions have been characterized. Here, using affinity purification mass spectrometry, we constructed interactomes for 6 human 12 Drosophila α-arrestins. resulting high-confidence comprised 307 467 prey proteins in ,...
The α-arrestins form a large family of evolutionally conserved modulators that control diverse signaling pathways, including both G-protein-coupled receptor (GPCR)-mediated and non-GPCR-mediated across eukaryotes. However, unlike β-arrestins, only few α-arrestin targets functions have been characterized. Here, using affinity purification mass spectrometry, we constructed interactomes for 6 human 12 Drosophila α-arrestins. resulting high-confidence comprised 307 467 prey proteins in ,...
Abstract The α-arrestins form a large family of evolutionally conserved modulators that control diverse signaling pathways, including both G-protein-coupled receptor-(GPCR-) mediated and non-GPCR across eukaryotes. However, unlike β-arrestins, only few α-arrestin targets functions have been characterized. Here, using affinity purification mass spectrometry, we constructed interactomes for six human twelve Drosophila α-arrestins. resulting high-confidence comprised 307 467 prey proteins in ,...
Abstract The α-arrestins form a large family of evolutionally conserved modulators that control diverse signaling pathways, including both G-protein-coupled receptor (GPCR-) mediated and non-GPCR across eukaryotes. However, unlike β-arrestins, only few α-arrestin targets functions have been characterized. Here, using affinity purification mass spectrometry, we constructed interactomes for six human twelve Drosophila α arrestins. resulting high-confidence comprised 307 467 prey proteins in...
The α-arrestins form a large family of evolutionally conserved modulators that control diverse signaling pathways, including both G-protein-coupled receptor- (GPCR-) mediated and non-GPCR across eukaryotes. However, unlike β-arrestins, only few α-arrestin targets functions have been characterized. Here, using affinity purification mass spectrometry, we constructed interactomes for six human twelve Drosophila α- arrestins. resulting high-confidence comprised 307 467 prey proteins in ,...
The α-arrestins form a large family of evolutionally conserved modulators that control diverse signaling pathways, including both G-protein-coupled receptor-(GPCR-) mediated and non-GPCR across eukaryotes. However, unlike β-arrestins, only few α-arrestin targets functions have been characterized. Here, using affinity purification mass spectrometry, we constructed interactomes for six human twelve Drosophila α-arrestins. resulting high-confidence comprised 307 467 prey proteins in ,...