A5026797185- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Medicinal plant effects and applications
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Biological Activity of Diterpenoids and Biflavonoids
- Peptidase Inhibition and Analysis
- Estrogen and related hormone effects
- Genomics, phytochemicals, and oxidative stress
- Diverse Scientific Research in Ukraine
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Lipids, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
Polish Academy of Sciences
2024-2025
Jeju National University
2021-2022
Estrogen receptors are indicators of breast cancer adaptability to endocrine therapies, such as tamoxifen. Deficiency or absence estrogen receptor α (ER-α) in cells results reduced efficacy therapy. Here, we investigated the effect combined tamoxifen and pentadecanoic acid therapy on ER-α-under-expressing cells. Drug resistance gene expression patterns were determined by RNA sequencing analysis vitro experiments. For first time, demonstrate that treatment acid, an odd-chain fatty...
Abstract Chalcones compounds have been investigated to exhibit anticancer activity through various physiological modes of action. In order develop chalcone with novel anticancer-related action, diverse were designed and synthesized. Variously substituted poly-methoxy 1 – 17 prepared, their structures identified using high-resolution mass spectrometry (HR/MS) nuclear magnetic resonance (NMR) experiments. Long-term survival clonogenic assay was applied evaluate anti-cancer abilities revealed...
Triple-negative breast cancer (TNBC) is associated with poor prognosis because of the lack effective therapies. Mixed-lineage protein kinase 3 (MLK3) a that often upregulated in TNBC and involved driving tumorigenic potential cells. Here, we present selective MLK3 degrader, CEP1347-VHL-02, based on pan-MLK inhibitor CEP1347 ligand for E3 ligase von Hippel–Lindau (VHL) by employing proteolysis-targeting chimera (PROTAC) technology. Our compound effectively targeted degradation via...
Abstract Mixed-lineage kinase 3 (MLK3) is a member of the MLK family serine/threonine kinases. MLK3 well-known to regulate MAPK signaling by acting upstream ERK, JNK, and p38 pathways. In addition its canonical role in activating cascades, regulates activity various proteins pathways, including NF-κB, Wnt/β-catenin, PAK1. Previous studies demonstrated that can promote proliferation, invasive growth, metastatic potential human cancers. Triple-negative breast cancer (TNBC) subtype...
Targeting cancer stem cell metabolism has emerged as a promising therapeutic strategy for treatment. Breast cells (BCSCs) exert distinct machinery, which plays major role in radiation and multidrug resistance. Therefore, exploring the mechanisms involved energy utilization of BCSCs could improve effectiveness strategies aimed at their elimination. This study was conducted to clarify glucose machinery function nootkatone, bioactive component grapefruit, regulating stemness characteristics...
Ampelopsin, also known as dihydromyricetin, is a commonly found flavonoid in medicinal plants. The cancer stem cell (CSC) population promising target for triple-negative breast (TNBC). In this study, screening was performed the established MDA-MB-231/IR line, which enriched CSCs. Ampelopsin suppressed proliferation and colony formation of cell-rich MDA-MB-231/IR, while inducing their apoptosis. Importantly, ampelopsin displayed an inhibitory impact on stemness features cells, demonstrated by...