A5047082774- dental development and anomalies
- Oral and Maxillofacial Pathology
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Bone and Dental Protein Studies
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- 3D Printing in Biomedical Research
- Hedgehog Signaling Pathway Studies
- Health Education and Validation
- Tumors and Oncological Cases
- Innovations in Medical Education
- Tracheal and airway disorders
- Fibroblast Growth Factor Research
- Genetic Mapping and Diversity in Plants and Animals
- Dental Research and COVID-19
University of Helsinki
2012-2024
Helsinki University Hospital
2021-2024
Czech Academy of Sciences, Institute of Biotechnology
2021
Tooth renewal is initiated from epithelium associated with existing teeth. The development of new teeth requires dental epithelial cells that have competence for tooth formation, but specific marker genes these not been identified. Here, we analyzed expression patterns the transcription factor Sox2 in two different modes successional formation: replacement and serial addition primary We observed lamina gives rise to mammals one round as well reptiles continuous replacement. was also...
In Finland, the frequency of isolated cleft palate (CP) is higher than that lip with or without (CL/P). This trend contrasts to in other European countries but its genetic underpinnings are unknown. We conducted a genome-wide association study Finnish population and identified rs570516915, single nucleotide polymorphism highly enriched Finns, as strongly associated CP (P = 5.25 × 10−34, OR 8.65, 95% CI 6.11–12.25), not CL/P 7.2 10−5), significance. The risk allele rs570516915 parallels...
Ameloblastomas are locally invasive odontogenic tumors that exhibit a high rate of recurrence and often associate with the third molars. They suggested to originate from dental epithelium because tumor cells resemble epithelial developing teeth. Expression transcription factor SOX2 has been previously localized in stem progenitor teeth as well various tumors. Here, we show is expressed follicular plexiform ameloblastomas. was lamina human primary It also fragmented associated molars budding...
Continuous growth of rodent incisors relies on epithelial stem cells (SCs) located in the SC niche called labial cervical loop (LaCL). Here, we found a population apoptotic residing specific location LaCL mouse incisor. Activated Caspase 3 and 9, expressed this colocalized part with Lgr5 putative SCs. The addition inhibitors to ex vivo resulted concentration dependent thickening LaCL. To examine role Wnt signaling regulation apoptosis, exposed postnatal day 2 (P2) incisor BIO, known...
Ptch receptors 1 and 2 mediate Hedgehog signaling pivotal for organ development homeostasis. In contrast to embryonic lethal Ptch1 −/− phenotype, Ptch2 mice display no effect on gross phenotype. this brief report, we provide evidence of changes in the putative incisor mesenchymal stem cell (MSC) niches that contribute accelerated growth, as well intriguing bones skin which suggest a role regulation MSCs their regenerative potential. We employed histological, immunostaining, computed...
Abstract In Finland the frequency of isolated cleft palate (CP) is higher than that lip (CL) or with (CLP). This trend contrasts to in other countries but its genetic underpinnings are unknown. We performed a genome-wide association study for orofacial cleft, which includes CL, CLP, and CP Finnish population. identified rs570516915, single nucleotide polymorphism virtually specific Finns Estonians, as being strongly associated predominantly (p = 5.25 x 10 -34 , OR 8.65, 95% CI 6.11-12.25)....
Abstract In Finland the frequency of isolated cleft palate (CP) is higher than that lip with or without (CL/P). This trend contrasts to in other European countries but its genetic underpinnings are unknown. We performed a genome-wide association study for orofacial clefts, which include CL/P and CP, Finnish population. identified rs570516915, single nucleotide polymorphism highly enriched Finns Estonians, as being strongly associated CP ( P = 5.25 × 10 −34 , OR 8.65, 95% CI 6.11–12.25), not...
OBJECTIVE Remote teaching strategies have been widely adapted in recent years but their impact on dental students' learning outcomes is less well understood. The aim of this mixed-method pilot study was to examine the remote undergraduate student's outcome as assessed by examination performance and student feedback an orthodontics course. METHODS Out lectures (19 total), 10 were delivered remotely (live online lecture or video recording) 9 traditional classroom 2023. course examination,...
Organ development, function, and regeneration depend on stem cells, which reside within discrete anatomical spaces called cell niches. The continuously growing mouse incisor provides an excellent model to study tissue-specific cells. epithelial cells of the are located at proximal end tooth in a niche cervical loop. They provide continuous influx counterbalance constant abrasion self-sharpening tip tooth. Presented here is detailed protocol for isolation culture that houses their niche. This...
Organ development, function, and regeneration depend on stem cells, which reside within discrete anatomical spaces called cell niches. The continuously growing mouse incisor provides an excellent model to study tissue-specific cells. epithelial cells of the are located at proximal end tooth in a niche cervical loop. They provide continuous influx counterbalance constant abrasion self-sharpening tip tooth. Presented here is detailed protocol for isolation culture that houses their niche. This...