A5021219326- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Acute Myocardial Infarction Research
- Peripheral Artery Disease Management
- Congenital Heart Disease Studies
- Optical Coherence Tomography Applications
- Vascular Procedures and Complications
- Cardiovascular and Diving-Related Complications
- Coronary Artery Anomalies
- Cardiac Arrhythmias and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Conditions and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Kidney Injury Research
- Aortic Disease and Treatment Approaches
- Cardiac pacing and defibrillation studies
- Cardiac and Coronary Surgery Techniques
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Chronic Kidney Disease and Diabetes
- Hemodynamic Monitoring and Therapy
Yale University
2022-2025
Instituto Dante Pazzanese de Cardiologia
2015-2024
Instituto Tecnológico de Querétaro
2024
Cardiovascular Research Center
2013-2023
Imperial College London
2020-2023
Boston Scientific (Netherlands)
2020
Abbott Vascular (United States)
2020
ZNA Middelheim Hospital
2020
Abbott (Sweden)
2020
Erasmus University Rotterdam
2017
Background: Coronary artery calcification (CAC) presents unique challenges for percutaneous coronary intervention. Calcium appears as a signal-poor region with well-defined borders by frequency-domain optical coherence tomography (FD-OCT). The objective of this study was to demonstrate the accuracy intravascular FD-OCT determine distribution CAC. Methods and Results: Cadaveric arteries were imaged using at 100-μm frame interval. Arteries subsequently frozen, sectioned 20-μm intervals Case...
The rupture of thin-cap fibroatheroma accounts for most acute coronary events. Optical Coherence Tomography (OCT) allows quantification fibrous cap (FC) thickness in vivo. Conventional manual analysis, by visually determining the thinnest part FC is subject to inter-observer variability and does not capture 3-D morphology FC. We propose validate a computer-aided method that volumetric analysis radial boundary semi-automatically segmented using dynamic programming algorithm. at every point...
To investigate safety and feasibility of imaging unprotected left main (ULM) using frequency-domain optical coherence tomography (FD-OCT) compared with intravascular ultrasound (IVUS).IVUS has been used to assess guide percutaneous coronary intervention (PCI) ULM disease. FD-OCT offers 10-fold higher axial resolution than IVUS its high-speed image acquisition obviates the need for proximal balloon occlusion.We prospectively enrolled 35 consecutive patients assessments were attempted pre-...
Background: Specific algorithms for use of optical coherence tomography (OCT) to guide percutaneous coronary intervention (PCI) are scarce. Also, the relative benefits intravascular imaging guidance have not been tested against an optimized angiography-guided PCI strategy. In iSIGHT (Optical Coherence Tomography Versus Intravascular Ultrasound and Angiography Guide Percutaneous Coronary Interventions), we aimed investigate whether OCT-guided achieves noninferior stent expansion compared with...
Data continue to accumulate demonstrating the benefits of intravascular imaging guidance improve patient outcomes after percutaneous coronary intervention (PCI)1Stone GW Christiansen EH Ali ZA et al.Updated network meta-analysis imaging-guided drug-eluting stent implantation.Lancet (London, England). 2024; https://doi.org/10.1016/S0140-6736(23)02454-6Abstract Full Text PDF Google Scholar and potential identify high-risk vulnerable plaques.2Stone G.W. Maehara A. Lansky A.J. al.A prospective...
Intravascular optical coherence tomography (iOCT) is being used to assess viability of new coronary artery stent designs. We developed a highly automated method for detecting struts and measuring tissue coverage. trained bagged decision trees classifier classify candidate using features extracted from the images. With 12 best identified by forward selection, recall (precision) were 90%-94% (85%-90%). Including deemed insufficiently bright manual analysis, precision improved 94%. Strut...
Approximately 30% to 50% of patients who are referred for diagnostic coronary angiography found have no obstructive artery disease (CAD). Ischemia and nonobstructive arteries (INOCA) is increasingly recognized encompasses microvascular dysfunction, vasospastic angina, symptomatic myocardial bridging, other vasomotor disorders. However, the prevalence these disorders whether underlying atherosclerotic plaque burden morphology affect long-term outcomes each physiologic phenotype unknown.
Background— To assess the vessel-healing pattern of Ultimaster drug-eluting stent using optical frequency domain imaging. Our hypothesis is that biodegradable polymer-based technology allows complete very early strut coverage. Methods and Results— The DISCOVERY 1TO3 study (Evaluation With OFDI Strut Coverage Terumo New Drug Eluting Stent Biodegradable Polymer at 1, 2, 3 Months) a prospective, single-arm, multicenter study. A total 60 patients with multivessel disease requiring staged...
This study sought to assess the safety and effectiveness of drug-filled stent (DFS) (Medtronic, Santa Rosa, California) in treatment patients with coronary artery disease. Polymer-free drug-eluting stents have potential improve clinical outcomes facilitate shorter durations dual antiplatelet therapy. The polymer-free DFS is made from a trilayered continuous wire an outer cobalt chromium layer, middle tantalum inner lumen coated sirolimus. Small laser-drilled holes on abluminal surface...
Background Scoring balloons produce excellent acute results in the treatment of in‐stent restenosis (ISR), fibro‐calcific and bifurcation lesions but have not been shown to affect rate. A novel paclitaxel‐coated scoring balloon (SB) was developed tested overcome this limitation. Methods Results SB were coated with paclitaxel admixed a specific excipient. Patients at four clinical sites Germany one Brazil ISR coronary bare metal stent (BMS) randomized 1:1 either drug‐coated or uncoated SB....