A5103266609- Cardiac Ischemia and Reperfusion
- Plasma Diagnostics and Applications
- Catalytic Processes in Materials Science
- MRI in cancer diagnosis
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Plasma Applications and Diagnostics
- Mitochondrial Function and Pathology
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- Radiomics and Machine Learning in Medical Imaging
- Lipoproteins and Cardiovascular Health
Gachon University Gil Medical Center
2016
Catholic University of Korea
2015
Chonnam National University
2015
We examined the efficacy of poziotinib, a second-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in patients with lung adenocarcinoma activating EGFR mutations, who developed acquired resistance (AR) to EGFR-TKIs.This single-arm phase II study included EGFR-mutant AR erlotinib or gefitinib based on Jackman criteria. Patients received poziotinib 16 mg orally once daily 28-day cycle. The primary endpoint was progression-free survival (PFS). Prestudy tumor...