A5043215508- Proteins in Food Systems
- Polysaccharides Composition and Applications
- Metabolism, Diabetes, and Cancer
- Surfactants and Colloidal Systems
- Diabetes Treatment and Management
- Pickering emulsions and particle stabilization
- Food composition and properties
- Diet and metabolism studies
- Enzyme Catalysis and Immobilization
- Diabetes Management and Research
- Food Allergy and Anaphylaxis Research
- Protein Hydrolysis and Bioactive Peptides
- Microencapsulation and Drying Processes
- Liver Disease Diagnosis and Treatment
- Muscle metabolism and nutrition
- Folate and B Vitamins Research
- Occupational exposure and asthma
- Agriculture Sustainability and Environmental Impact
- Lipid metabolism and biosynthesis
- Probiotics and Fermented Foods
- Advanced Polymer Synthesis and Characterization
- Electrostatics and Colloid Interactions
- Biochemical Analysis and Sensing Techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Algal biology and biofuel production
Eli Lilly (Ireland)
2022-2025
University of Leeds
2017-2022
University of Nottingham
2014-2018
Universidad de Granada
2008-2013
An improved understanding of the behaviour lipids within gastrointestinal tract will facilitate structural design foods that provide specific physiological responses. In this work, we studied influence interfacial characteristics (emulsifier type and surface area) on emulsified a simulated small intestine (duodenum). Pluronic F68-stabilized emulsions were more resistant to lipid digestion than lecithin-stabilized emulsions. Interfacial tension, droplet charge (ζ-potential), microstructure...
It is important to understand how interfacial composition influences the digestion of coated interfaces in order rationally design emulsion based food products with specific profiles. This study has been designed investigate effects gastrointestinal on protein covered interfaces. In this work, we have used a new apparatus fully and assembled at University Granada: OCTOPUS. device enables customised static sequential vitro process single droplet. Physiological conditions each compartment/step...
Pluronics are being introduced in food research order to delay lipid digestion, with the length of hydrophilic and hydrophobic chains playing an important role rate such a process. Since bile salts play crucial digestion process, aim this work is analyze interactions between Pluronic F127 or F68 salt NaTDC when latter added at physiological concentrations. These studied Pluronic-covered oil-water interface aqueous phase Pluronic-stabilized emulsions. This has been carried out techniques as...
Cellulose ethers interact with bile salts in the aqueous phase. These interactions are affected by substituent type/pattern of cellulose rather than their molecular weight and hydrophobicity salts.
Evaluating the gastrointestinal (GI) fate of proteins is part assessment to determine whether are safe consume. In vitro digestion tests often used for screening purposes in evaluation potential allergenicity. However, current pepsin resistant test by European Food Safety Authority, only corresponds fasted gastric conditions representative a late phase adult stomach. addition, these performed on isolated and effect food matrix processing not systematically considered. The aim this research...
Abstract Vancomycin, a branched tricyclic glycosylated peptide antibiotic, is last-line defence against serious infections caused by staphylococci, enterococci and other Gram-positive bacteria. Orally-administered vancomycin the drug of choice to treat pseudomembranous enterocolitis in gastrointestinal tract. However, risk vancomycin-resistant enterococcal infection or colonization significantly associated with oral vancomycin. Using powerful matrix-free assay co-sedimentation analytical...
OBJECTIVE To evaluate late (week 40 or 42; hereafter, week 40/42) metabolic outcomes by early glycemic response (<20% ≥20% fasting serum glucose [FSG] reduction at 4) weight (<5% ≥5% 8), respectively, in tirzepatide-treated participants with type 2 diabetes the SURPASS trials. RESEARCH DESIGN AND METHODS This post hoc analysis used pooled data across Baseline characteristics, change from baseline to 40/42 for efficacy parameters, and gastrointestinal (GI) adverse events (AEs)...
<p dir="ltr">Objective To evaluate late (Week 40/42) metabolic outcomes by early glycemic response (<20% or ≥20% fasting serum glucose [FSG] reduction at Week 4) weight (<5% ≥5% 8), respectively, in tirzepatide-treated participants with type 2 diabetes the SURPASS trials. Research Design and Methods This post hoc analysis used pooled data across Baseline characteristics, change from baseline to 40/42 for efficacy parameters, gastrointestinal adverse events (GI AEs) were described...
<p dir="ltr">Objective To evaluate late (Week 40/42) metabolic outcomes by early glycemic response (<20% or ≥20% fasting serum glucose [FSG] reduction at Week 4) weight (<5% ≥5% 8), respectively, in tirzepatide-treated participants with type 2 diabetes the SURPASS trials. Research Design and Methods This post hoc analysis used pooled data across Baseline characteristics, change from baseline to 40/42 for efficacy parameters, gastrointestinal adverse events (GI AEs) were described...
The use of nanoparticles as drug delivery systems is an emerging application to improve intravenous therapy. Controlling the biocompatibility a crucial step towards optimal implementation these systems. Adsorption serum components onto driven mainly by hydrophobic forces. Thus, incorporation hydrophilic polymers such polyethylene oxide (PEO) derivatives nanostructure surface reduces interaction with blood stream (IgG). effectiveness poloxamer for reducing protein adsorption depends on...
To assess composite endpoints combining glycaemic control (HbA1c < 7.0%, ≤ 6.5% or 5.7%) with weight loss (≥ 5%, ≥ 10% 15%) and without hypoglycaemia tirzepatide in type 2 diabetes (T2D).Data from the phase 3 SURPASS programme were evaluated post hoc by trial. Participants T2D randomized to (5, 10 15 mg), placebo (SURPASS-1,5), semaglutide 1 mg (SURPASS-2) titrated basal insulin (SURPASS-3,4). The proportions of participants achieving compared between respective comparator groups at week...
Calcium plays an important dual role in lipid digestion: promoting removal of long-chain fatty acids from the oil-water interface by forming insoluble calcium soaps while also limiting their bioaccessibility. This becomes more significant food containing high concentration, such as dairy products. Nevertheless, scarce attention has been paid to effect on interfacial properties during digestion, despite this being largely reaction. study focused dynamics formation at lipolysis pancreatic...