A5019065736- Neuropeptides and Animal Physiology
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Proteoglycans and glycosaminoglycans research
- Receptor Mechanisms and Signaling
- Connective tissue disorders research
- Renin-Angiotensin System Studies
- Peroxisome Proliferator-Activated Receptors
- Neuroinflammation and Neurodegeneration Mechanisms
- Signaling Pathways in Disease
- Cyclopropane Reaction Mechanisms
- Protease and Inhibitor Mechanisms
Georgetown University Medical Center
2018-2021
Georgetown University
2018-2021
Institute of Pharmacology
2020
Emerging evidence suggests that there is a reduction in overall cortical excitatory to inhibitory balance major depressive disorder (MDD), which afflicts ∼14%-20% of individuals. Reduced pyramidal cell arborization occurs with stress and MDD, may diminish neurotransmission. Enhanced deposition perineuronal net (PNN) components also stress. Since parvalbumin-expressing interneurons are the predominant population enveloped by PNNs, enhance their ability release GABA, excess PNN likely...
Drugs that target monoaminergic transmission represent a first-line treatment for major depression. Though full understanding of the mechanisms underlie antidepressant efficacy is lacking, evidence supports role enhanced excitatory transmission. This can occur through two non-mutually exclusive mechanisms. The first involves increased function neurons relatively direct such as dendritic arborization. Another mechanism reduced inhibitory function, which occurs with rapid ketamine. Consistent...
Abstract Drugs that target monoaminergic transmission represent a first-line treatment for major depression. Though full understanding of the mechanisms underlie antidepressant efficacy is lacking, evidence supports role enhanced excitatory transmission. This can occur through two non-mutually exclusive mechanisms. The first involves increased function neurons relatively direct such as dendritic arborization. Another mechanism reduced inhibitory function, which occurs with rapid ketamine....
Abstract Emerging evidence suggests that there is a reduction in overall cortical excitatory to inhibitory balance major depressive disorder (MDD), which afflicts approximately 14-20% of individuals. Reduced pyramidal cell arborization occurs with stress and MDD, may diminish neurotransmission. Enhanced deposition perineuronal net (PNN) components also stress. Since parvalbumin-expressing interneurons are the predominant population enveloped by PNNs, enhance their ability release GABA,...