A5075408630- Bone Metabolism and Diseases
- RNA modifications and cancer
- TGF-β signaling in diseases
- RNA Research and Splicing
- Hormonal Regulation and Hypertension
- Bone Tissue Engineering Materials
- Bone health and treatments
- RNA regulation and disease
- Pancreatic function and diabetes
- Cancer-related Molecular Pathways
- Mitochondrial Function and Pathology
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Periodontal Regeneration and Treatments
- Drug Transport and Resistance Mechanisms
- RNA and protein synthesis mechanisms
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Mesenchymal stem cell research
Imperial College London
2019-2022
MRC London Institute of Medical Sciences
2019-2022
Hammersmith Hospital
2022
Universitat de Barcelona
2012-2019
Institut d'Investigació Biomédica de Bellvitge
2012-2019
Understanding the molecular events that regulate osteoblast differentiation is essential for development of effective approaches to bone regeneration. In this study, we analysed osteoinductive properties extracellular calcium in marrow-derived mesenchymal stem cell (BM-MSC) differentiation. We cultured BM-MSCs 3D gelatin scaffolds with Ca2+ and BMP-2 as agents. Early late osteogenic gene expression regeneration a calvarial critical-size defect model demonstrate enhances effects on...
Abstract RNA alternative splicing (AS) expands the regulatory potential of eukaryotic genomes. The mechanisms regulating liver-specific AS profiles and their contribution to liver function are poorly understood. Here, we identify a key role for factor RNA-binding Fox protein 2 (RBFOX2) in maintaining cholesterol homeostasis lipogenic environment liver. Using enhanced individual-nucleotide-resolution ultra-violet cross-linking immunoprecipitation, physiologically relevant targets RBFOX2 mouse...
Pre-mRNA processing is an essential mechanism for the generation of mature mRNA and regulation gene expression in eukaryotic cells. While defects pre-mRNA have been implicated a number diseases their involvement metabolic pathologies still unclear. Here, we show that both alternative splicing polyadenylation, two major steps processing, are significantly altered non-alcoholic fatty liver disease (NAFLD). Moreover, find Serine Arginine Rich Splicing Factor 10 (SRSF10) binding enriched...
Osteocytes, the most abundant of bone cells, differentiate while they remain buried within matrix. This encasement limits their access to nutrients and likely affects differentiation, a process that remains poorly defined. Here, we show restriction in glucose supply promotes osteocyte transcriptional program also being associated with increased mitochondrial DNA levels. Glucose deprivation triggered activation AMPK/PGC-1 pathway. AMPK SIRT1 activators or PGC-1α overexpression are sufficient...
Coupling metabolic and reproductive pathways is essential for the survival of species. However, functions steroidogenic enzymes expressed in tissues are largely unknown.Here, we show that liver, classical enzyme Cyp17a1 forms an nexus glucose ketone metabolism during feed-fast cycles. Both gain- loss-of-function approaches used to hepatic induced by fasting, catalyzes production at least one hormone-ligand (DHEA) nuclear receptor PPARα, ultimately required maintaining euglycemia ketogenesis...
The delivery of osteogenic factors is a proven therapeutic strategy to promote bone regeneration. Bone morphogenetic proteins (BMPs) constitute family cytokines with well-known and regenerative abilities. However, clinical uses BMPs require high doses that have been associated complications such as osteolysis, ectopic formation, or hematoma formation. In the present work, we sought improve tissue engineering through an approach combines use marrow-derived mesenchymal stem cells (BMMSCs),...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)