We report on the electrochemical detection of anti-cancer drugs in human serum with sensitivity values range 8–925 nA/µM. Multi-walled carbon nanotubes were functionalized three different cytochrome P450 isoforms (CYP1A2, CYP2B6, and CYP3A4). A model used to effectively describe deposition onto was confirmed by Monte Carlo simulations. Voltammetric measurements performed phosphate buffer saline (PBS) as well serum, giving well-defined current responses upon addition increasing concentrations...

We attempt to examine the potential of silicon nanowire memristors in field nanobiosensing. The memristive devices are crystalline Silicon (Si) Nanowires (NWs) with Nickel Silicide (NiSi) terminals. nanowires fabricated on a Silicon-on-Insulator (SOI) wafer by an Ebeam Lithography Technique (EBL) process that allows high resolution at nanoscale. A Deep Reactive Ion Etching (DRIE) technique is used define free-standing nanowires. close alignment between and Nickel-Silicide terminals forms...

We describe an integrated biosensor capable of sensing multiple molecular targets using both cyclic voltammetry (CV) and chronoamperometry (CA). In particular, we present our custom IC to realize voltage control current readout the biosensors. A mixed-signal circuit block generates sub-Hertz triangular waveform for biosensors by means a direct-digital-synthesizer CV. pulse-width converter is realized output data CA measurement. The fabricated in 0.18 μm technology. It consumes 220 μW from...

In this work, we show the realization of a fully-implantable device for monitoring free-moving small animals. The integrates microfabricated sensing platform, coil power and data transmission two custom designed integrated circuits. is intended to be implanted in mice, free move cage, monitor concentration metabolites. We system level design each block device, present fabrication passive platform its employment electrochemical detection endogenous exogenous Moreover, describe assembly test...

A system for wireless power transfer and data communication of implantable bio-monitoring systems is presented. The proposed solution uses a servo-controlled transmitter moved under the animal moving space. An <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x-y</i> movable magnetic coil transmits required with level able to keep constant received energy by bio-sensor system. transferred via optimized remote powering link at 13.56 MHz. ac signal...

Biosensing for chronic pathologies requires the simultaneous monitoring of different parameters such as drug concentrations, inflammation status, temperature and pH. In this paper we discuss design, fabrication test a sensor array hosting five biosensor platforms, pH electrode sensor. Different reproducible nano-bio-functionalization can be obtained with high spatial resolution via selective electrodeposition chitosan/MWCNT/enzyme solutions at various electrodes. The array, completely...

Monitoring patients in intensive care units is generally expensive and time consuming. A prompter medical intervention for those critical a key factor their safety. Therefore, system that offers immediate visualization of the monitored data represents great advance field. In this paper, design, development, validation an android interface continuous wireless monitoring up to five compounds are described. Continuous biomolecules addressed by using fully integrated hardware platform consisting...

Multi-target and continuous monitoring by wireless implantable devices is of increasing interest for personalized therapy. In this work an system presented which capable measuring different drugs with Cyclic Voltammetry (CV) method. The microsystem consists four modules, namely (i) inductive coil; (ii) Power management IC; (iii) Readout control (iv) Biosensor array. power IC provides 1.8 V as high 2 mW the readout IC. configurable able to biosensor array measure sensor current in CV...

The development of new technologies to monitor drugs concentration directly in patient's blood is absolutely required succeed personalized drug therapies. In this study, Etoposide - a well-known anti-cancer has been chosen as model for cyclic voltammetry detection drugs. Carbon nanotubes are electron-transfer mediators enhance the system sensitivity. A very low frequency and slope triangular-wave potential acquire voltammograms. Cyclic voltammograms definitely needed correct identification...

The IronIC project has the aim of developing a fully implantable and remotely powered platform for real-time monitoring human metabolites. In this paper we present mixed-signal interface IC electrochemical sensing data acquisition chain. controls reads out up to five biomolecular sensors, by receiving commands from standard conduct chronoamperometry (CA) cyclic voltammetry (CV). Different voltage profiles are generated using single on-chip reconfigurable waveform generator, while measured...

This paper presents the in-vivo tests on a Fully Implantable Multi-Panel Devices for Remote Monitoring of endogenous and exogenous analytes. To investigate issues biocompatibility, three different covers have been designed, realized tested in mice 30 days. ATP neutrophil concentrations measured, at implant site after device was explanted, to assess level biocompatibility device. Finally, fully working prototypes were implanted tested. The devices used detect variations physiological glucose...

Abstract In this work we present an investigation on the behavior of microsomes containing human cytochrome P450 in cyclic voltammetry for drug detection. The are adsorbed surface multi‐walled carbon nanotubes by drop‐casting. We demonstrate that hydrophobic and highly electroactive enables to distinguish more clearly contributions reduction peak current attributed enzymatic components microsomes. Voltammetric measurements were performed under several experimental conditions with two...

In this work, we showed the realization of a fully-implantable device that integrates microfabricated sensing platform , coil for power and data transmission integrated circuits. We described intended to test biocompatibility materials used microfabrication. Therefore, electronics measurements communication remote powering will be reported in another article [1]. To ensure an epoxy enhanced polyurethane membrane was cover device. proved through in-vitro characterization capable retain enzyme...

Biosensors are heterogenous devices, incorporating biological structures combined with electronics, optical or other readout systems. They have been developed for detecting different biomolecules and/or pathogens and represent a key technology advanced point-of-care diagnostics as well patient monitoring. In this paper we present systematic classification of biosensors described in literature, particularly focusing on nanotechnology-based sensing. Then, our approach to develop...

In this paper, a new approach for evaluating the performance of multi-panel biosensor using linear algebra is presented. With system-level mathematical analysis based on graphs and algebra, we formulate contributions decoupling in biochip simultaneous detection anti-cancer drugs, avoiding redundancy interaction between enzymes. Experimental results have been used to validate model.

A full remotely powered system for metabolism monitoring of free-moving mice is presented here. The fully implantable sensing platform hosts two ASICs, one off-the-shelf micro-controller, four biosensors, other sensors, a coil to receive power, and an antenna transmit data. Proper enzymes ensure specificity animal metabolites while Multi-Walled Carbon Nanotubes the due sensitivity. remote powering indeed provided by inductive coils located under floor mouse' cage. Two different approaches...

A multi-sensing platform for applications in wireless and batteryless monitoring of free-moving small animals is presented this paper. The proposed hosts six sensors: four biosensors sensing both disease biomarkers therapeutic compounds, two further sensors (T pH) biosensor calibration. Electrodeposition Multi-Walled Carbon Nanotubes (MWCNTs) the subsequent function-alization with proper enzymes used to assure sensitivity specificity electrochemical biosensing. realized are demonstrated be...

This paper compares three different biocompatible packaging covers suitable to support full implantation of multi-panel sensors for remote monitoring metabolism. The have been designed, realized and implanted in mice 30 days. ATP neutrophil concentrations measured at the implant site after device was explanted, assess level biocompatibility device.

Nowadays, scientific advances are leading to the discovery of newer, better, more targeted treatments that will improve human health. However, despite promising results and major advantages in offered patients, these personalized medical limited few cases. Translational medicine research with animals is needed find innovative, safe life-saving solutions for especially drug development. Although technological improvements may lead one day end animal testing, today those strategies not...