About
Contact & Profiles
A5031133271
Research Areas
- Prion Diseases and Protein Misfolding
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
University of Glasgow
2021
Significance The M1 muscarinic acetylcholine receptor (M1-receptor) plays a crucial role in learning and memory is validated drug target for the treatment of Alzheimer’s disease (AD). Furthermore, M1-receptor ligands have been demonstrated to display disease-modifying effects preclinical models neurodegenerative disease. By employing genetic mouse model expressing G protein–biased combination with terminal disease, we demonstrate here that exerts an inherent neuroprotective activity...
10.1073/pnas.2107389118
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Proceedings of the National Academy of Sciences
2021-12-10
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