Abstract Motility is a fundamental survival strategy of bacteria to navigate porous environments, where they mediate essential biogeochemical processes in quiescent wetlands and sediments. However, comprehensive understanding the mechanisms regulating self-transport confined interstices media lacking, determining interactions between cells surfaces solid matrix becomes paramount. Here, we precisely track movement ( Magnetococcus marinus ) through series microfluidic with broadly varying...

The natural habitats of planktonic and swimming microorganisms, from algae in the oceans to bacteria living soil or intestines, are characterized by highly heterogeneous fluid flows. complex interplay flow-field topology, self-propulsion, porous microstructure is essential a wide range biophysical ecological processes, including marine oxygen production, remineralization organic matter, biofilm formation. Although much progress has been made understanding microbial hydrodynamics surface...

Technologies capable of noninvasively sampling different locations in the gut upstream colon enable new insights into role organ‐specific microbiota human health. Herein, an ingestible, biocompatible, battery‐less, 3D‐printed microengineered pill with integrated osmotic sampler and microfluidic channels for vivo lumen its microbiome is discussed. The pill's performance characterized using realistic vitro models validated pigs primates. results show that bacterial populations recovered from...

We present a theoretical framework for describing an impurity in trapped Bose system one spatial dimension. The theory handles any external confinement, arbitrary mass ratios, and weak interaction may be included between the particles. To demonstrate our technique, we calculate ground-state energy properties of sample with eight bosons find excellent agreement numerically exact results. Our can thus provide definite predictions experiments cold atomic gases.

Strongly interacting one-dimensional quantum systems often behave in a manner that is distinctly different from their higher-dimensional counterparts. When particle attempts to move environment it will unavoidably have interact and 'push' other particles order execute pattern of motion, irrespective whether the are fermions or bosons. A present frontier both theory experiment mixed species and/or with multiple internal degrees freedom. Here we consider trapped two-component bosons...

A new solvable model of interacting quantum particles exhibits a broader range dynamical behavior than previous models, which could provide experimentalists with better insight into mixed-mass ensembles particles.

Strongly interacting particles in one dimension subject to external confinement have become a topic of considerable interest due recent experimental advances and the development new theoretical methods attack such systems. In case equal mass fermions or bosons with two more internal degrees freedom, can map problem onto well-known Heisenberg spin models. However, many interesting physical systems contain mixtures different masses. Therefore, generalization strong-coupling techniques would be...

Abstract Directed motility enables swimming microbes to navigate their environment for resources via chemo-, photo-, and magneto-taxis. However, directed competes with fluid flow in porous microbial habitats, affecting biofilm formation disease transmission. Despite this broad importance, a microscopic understanding of how impacts the transport microswimmers flows through constricted pores remains unknown. Through microfluidic experiments, we show that individual magnetotactic bacteria...

We develop a quantum simulator architecture that is suitable for the simulation of $\text{U}(1)$ Abelian gauge theories such as electrodynamics. Our approach relies on ability to control hopping particle through barrier by means internal states neutral or charged impurity sitting at barrier. This scheme experimentally feasible, correlated does not require fine-tuning intra- and interspecies interactions. investigate applicability in double-well potential, which basic building block...

A detailed analysis of a system four interacting ultracold fermions confined in one-dimensional harmonic trap is performed. The done the framework simple variational ansatz for many-body ground state, and its predictions are compared with results numerically exact diagonalization Hamiltonian. short discussion role quantum statistics, i.e., Bose-Bose Bose-Fermi mixtures, also presented. It concluded that ansatz, although appearing to be oversimplified, gives surprisingly good many different...

We study the correlation between an impurity and a small ensemble of bosonic particles in one dimension. Our analyzes one-body density matrix calculates corresponding von Neumann entanglement entropy as function interaction strength bosons when all have same mass. show that grows very fast for moderate then increases slowly toward strongly interacting regime. Then we effect over quantum correlations mass imbalance bosons. In case, discover is much heavier than bosons, least possible...

An ingestible lab-on-a-pill device capable of sampling the gut microbiome in vivo is shown, as described article number 1900053 by Sameer R. Sonkusale and co-workers. The uses an osmotic pump to acquire sample embedded microfluidic channels. It operates without a battery or any electronic components. A magnet enables tracking spatial localization. Detailed studies pigs primates validate performance pill.

We make use of a simple pair correlated wave function approach to obtain results for the ground-state densities and momentum distribution one-dimensional three-body bosonic system with different interactions in harmonic trap. For equal this is able reproduce known analytical cases zero infinite repulsion. show that our correlations agree exact diagonalization all interaction regimes strongly repulsive impurity. This method also enables us access more complicated mixed interactions,...

In this paper we study a mixed system of bosons and fermions with up to six particles in total. All are assumed have the same mass. The two-body interactions repulsive equal strength both Bose–Bose Fermi–Boson channels. confined externally by harmonic oscillator one-body potential. For case four particles, two identical bosons, focus on strongly interacting regime analyze using an analytical approach density matrix renormalization group calculations discrete version underlying continuum...

Fungal adhesion is fundamental to processes ranging from infections food production. We developed a microfluidic assay for rapid screening and fractionation of genetically-related yeast based on adhesive properties.

In vivo VHH discovery approaches have been limited by the lack of methodologies for camelid B cell interrogation. Here, we report a novel application Beacon® optofluidic platform to heavy-chain-only antibodies screening alpaca cells. Methods enrichment, culture, IgG2/3 detection, and sequencing were developed used discover target-specific from an immunized with prostate-specific membrane antigen (PSMA) or second target. PSMA-specific hits expressed as VHH-Fc characterized using label-free...

ABSTRACT In vivo discovery approaches for single domain antibodies such as VHH have been limited by the lack of methodologies available camelid B cell interrogation. Here, we report a novel application Berkeley Lights Beacon® optofluidic platform to heavy-chain-only screening cells from alpacas immunized with two different targets. Custom methods alpaca enrichment, culture, on-Beacon IgG2/3 detection, and sequencing were developed used discover target-specific candidates an either human...

Abstract Technologies capable of non-invasively sampling different locations in the gut upstream colon will enable new insights into role organ-specific microbiota human health. We present an ingestible, biocompatible, battery-less, 3D-printed micro-engineered pill with integrated osmotic sampler and microfluidic channels for vivo lumen its microbiome colon. The pill’s performance was characterized using realistic vitro models validated pigs primates. Our results show that bacterial...

In this thesis, I go through the well-known solutions to one and two-particle systems trapped in a quantum harmonic oscillator then continue three, four many-body systems. This is done by developing new analytical models numerical methods both for few- One-dimensional are very interesting sense that particles aligned on line can only change seats going each other. property be exploited strongly interacting regime, where forced sit specific configuration, which easily manipulated. The...

Fungal adhesion is fundamental to processes ranging frominfection food production yet, robust, population-scalequantification methods for yeast surface are lacking. We developed a microfluidic assay distinguish the effects of genetic background and solution conditions on adhesion. This approach will enable rapid screening adhesive properties anti-fouling surfaces host other applications.