A5076115729- Ion channel regulation and function
- Ion Channels and Receptors
- Cell death mechanisms and regulation
- Calcium signaling and nucleotide metabolism
- Neuroscience and Neuropharmacology Research
- Lipid Membrane Structure and Behavior
- Diet, Metabolism, and Disease
- Neurobiology and Insect Physiology Research
- Protein Kinase Regulation and GTPase Signaling
- Boron Compounds in Chemistry
- RNA Interference and Gene Delivery
- Circadian rhythm and melatonin
KU Leuven
2019-2022
Université de Lille
2019-2022
Inserm
2015-2022
Laboratoire d'Excellence Canaux Ioniques d'Intérêt Thérapeutique
2022
Toxicologie, Pharmacologie et Signalisation Cellulaire
2019
La Ligue Contre le Cancer
2015-2017
Deviation of the ambient temperature is one most ubiquitous stimuli that continuously affect mammals' skin. Although role warmth receptors in epidermal homeostasis (EH) was elucidated recent years, mystery keratinocyte mild-cold sensor remains unsolved. Here we report cloning and characterization a new functional isoform transient receptor potential M8 (TRPM8) receptor, dubbed TRPM8 (eTRPM8), which localized endoplasmic reticulum membrane controls mitochondrial Ca(2+) concentration...
The anti-apoptotic Bcl-2 protein is emerging as an efficient inhibitor of IP3R function, contributing to its oncogenic properties. Yet, the underlying molecular mechanisms remain not fully understood. Using mutations or pharmacological inhibition antagonize Bcl-2's hydrophobic cleft, we excluded this functional domain responsible for Bcl-2-mediated IP3Rs inhibition. In contrast, deletion C-terminus, containing trans-membrane domain, which only present in Bcl-2α, but Bcl-2β, led impaired...
Intracellular ion channels are involved in multiple signaling processes, including such crucial ones as regulation of cellular motility and fate. With 95% the membrane belonging to intracellular organelles, it is hard overestimate importance channels. Multiple studies have been performed on these over years, however, a unified approach allowing not only characterize their activity but also study by partner proteins, analogous patch clamp "golden standard", lacking. Here, we present universal...
Aim: Inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiquitous calcium (Ca2+) channel involved in the regulation of cellular fate and motility. Its modulation by anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) plays an important role cancer progression. Disrupting this interaction could overcome apoptosis avoidance, one hallmarks cancer, is, thus, great interest. Earlier reports have shown involvement both Bcl-2 homology 4 (BH4) transmembrane domains (TMDs) regulating IP3R activity,...
Bcl-2 is an important regulator of inositol 1,4,5-trisphosphate receptor (IP3R) activity and, thus Ca2+ release from internal stores and associated processes, including cellular proliferation death. The presence multiple regulatory domains in both proteins suggests a complex interaction. Earlier reports have shown the involvement BH4 transmembrane regulating IP3R activity, while hydrophobic cleft was primarily with its anti-apoptotic, IP3R-independent, action at mitochondria. Here, we show...