A5068786338- Circadian rhythm and melatonin
- Sleep and related disorders
- Sleep and Wakefulness Research
- Health and Medical Research Impacts
- Interdisciplinary Research and Collaboration
- Impact of Technology on Adolescents
- Biomedical and Engineering Education
- Health Policy Implementation Science
- Paranormal Experiences and Beliefs
- Green IT and Sustainability
- Spaceflight effects on biology
- Child Development and Digital Technology
- Cognitive and developmental aspects of mathematical skills
- Neuroscience of respiration and sleep
- Impact of Light on Environment and Health
- Anatomy and Medical Technology
National Center for Advancing Translational Sciences
2022-2023
National Institutes of Health
2023
University of Colorado Boulder
2013-2021
University of Colorado System
2020-2021
Chronotype is a construct reflecting individual differences in diurnal preference. Although chronotype has been studied extensively school-age children, adolescents and adults, data on young children are scarce. This study describes its relationship to the timing of circadian clock sleep 48 healthy aged 30-36 months (33.4 ± 2.1 months; 24 males). Parents completed Children's Questionnaire (CCTQ) ~2 weeks before start study. The CCTQ provides three measures chronotype: midsleep time free...
Circadian phase and its relation to sleep are increasingly recognized as fundamental factors influencing human physiology behavior. Dim light melatonin onset (DLMO) is a reliable marker of the timing circadian clock, which has been used in experimental, clinical, descriptive studies past few decades. Although DLMO relationship have well documented school-aged children, adolescents, adults, very little known about these processes early childhood. The purpose this study was 1) describe angles...
Although the light-induced melatonin suppression response is well characterized in adults, studies examining dynamics of this effect children are scarce. The purpose study was to quantify magnitude evening preschool-age children. Healthy (n = 10; 7 females; 4.3 ± 1.1 years) participated a 7-day protocol. On days 1–5, followed strict sleep schedule. day 6, entered dim light environment (<15 lux) for 1-h before providing salivary samples every 20- 30-min from afternoon until 50-min after...
Abstract Light at night in adults suppresses melatonin a nonlinear intensity‐dependent manner. In children, bright light of single intensity before bedtime has robust suppressing effect. To our knowledge, whether evening different intensities is related to suppression young children unknown. Healthy, good‐sleeping (n = 36; 3.0–4.9 years; 39% male) maintained stable sleep schedule for 7 days followed by 29.5‐h in‐home dim‐light circadian assessment (~1.5 lux). On the final protocol, received...
The timing of the internal circadian clock shows large inter-individual variability across lifespan. Although sleep-wakefulness pattern most toddlers includes an afternoon nap, association between napping and phase in early childhood remains unexplored. This study examined differences sleep non-napping toddlers. Data were collected on 20 (34.2±2.0 months; 12 females; 15 nappers). Children followed their habitual schedules (monitored with actigraphy) for 5 days before in-home salivary dim...
Light exposure and sleep timing are two factors that influence inter-individual variability in the of human circadian clock. The aim this study was to quantify degree which evening light predicts variance over above bedtime alone preschool children. Participants were 21 children ages 4.5–5.0 years (4.7±0.2 years; 9 females). Children followed their typical schedules for 4 days during time they wore a wrist actigraph assess pendant meter measure minute-by-minute illuminance levels lux. On 5th...
Late sleep timing is prevalent in early childhood and a risk factor for poor behavioral health outcomes. Sleep influenced by the phase of circadian clock, with later linked to delayed onset young children. Light strongest zeitgeber and, adults, evening light produces delay an intensity-dependent manner. The phase-shifting response children, however, currently unknown. In present study, 33 healthy, good-sleeping children aged 3.0 4.9 years (M = 4.14 years, 39% male) completed 10-day...
Abstract The National Center for Advancing Translational Science (NCATS) seeks to improve upon the translational process advance research and treatment across all diseases conditions bring these interventions who need them. Addressing racial/ethnic health disparities inequities that persist in screening, diagnosis, treatment, outcomes (e.g., morbidity, mortality) is central NCATS’ mission deliver more people quickly. Working toward this goal will require enhancing diversity, equity,...
Summary In adults, recent evidence demonstrates that sleep and circadian physiology change across lunar phases, including findings endogenous melatonin levels are lower near the full moon compared to new moon. Here, we extend these results early childhood by examining circalunar fluctuations in children's evening levels. We analysed extant data on young rhythms ( n = 46, aged 3.0–5.9 years, 59% female). After following a strict schedule for 5–7 days, children completed an in‐home, dim‐light...
The Student Academic Success Center is a multicultural learning community that supports students who are low income, first generation, and underrepresented at the University of Colorado Boulder. In order to improve undergraduate science outcomes for traditionally underserved in higher education, our department offers small sections high risk gateway courses. Prompted by performance large main campus section Human Anatomy, we developed this course department. Our Anatomy used same lecture...
Abstract Introduction In adults, exposure to light at night delays the timing of circadian clock in a dose-dependent manner with intensity. Although children’s melatonin levels are highly suppressed by evening bright light, sensitivity young is unknown. This research aimed establish an illuminance response curve for phase delay preschool children as result varying intensities hour before bedtime. Methods Healthy (n=36, 3.0 – 4.9 years, 39% males), participated 10-day protocol. For 7 days,...