A5013337684- Analytical Methods in Pharmaceuticals
- Hormonal and reproductive studies
- Pain Mechanisms and Treatments
- Pharmacological Effects and Assays
- Pharmaceutical studies and practices
- Advanced Chemical Sensor Technologies
- Drug-Induced Hepatotoxicity and Protection
- Pain Management and Opioid Use
- Pesticide Residue Analysis and Safety
- Advanced Drug Delivery Systems
- Muscle metabolism and nutrition
- Forensic Toxicology and Drug Analysis
- Analytical Chemistry and Chromatography
- Pharmacology and Obesity Treatment
- Veterinary Pharmacology and Anesthesia
- Cystic Fibrosis Research Advances
University of Iowa
2020-2023
Iowa City Public Library
2022
Translational Therapeutics (United States)
2020
Misr International University
2017
University of Maryland, Baltimore
2017
Optimizing a sustained-release drug delivery system for the treatment of cystic fibrosis is crucial decreasing dosing frequency and improving patients' compliance with regimen. In current work, we developed an injectable PLGA microparticle formulation loaded ivacaftor, CFTR potentiator that increases open probability anion channel, using single emulsion solvent evaporation technique. We aimed to study effect different parameters on characteristics prepared formulations select optimized be...
Abstract Chronic pain is a significant health problem associated with disability and reduced quality of life. Current management chronic inadequate only modest effects pharmacological interventions. Thus, there need for the generation analgesics treating pain. Although preclinical clinical studies demonstrate analgesic testosterone, use testosterone limited by adverse androgenic effects. Selective androgen receptor modulators (SARMs) activate receptors overcome treatment limitations...
Objectives: An ultra-performance liquid chromatography tandem mass spectrometry (UPLC–MS/MS) assay has been developed and validated for the quantification of oxycodone in rat serum brain tissue homogenates. Methods: A simple extraction method using methyl-t-butyl ether was used sample with oxycodone–D3 as an internal standard (IS). Symmetry® C18 column (100 mm x 4.6 mm, 5 µm) connected to a Phenomenex Luna® guard (4 3 chromatographic separation. The mobile phase composed mixture acetonitrile...
Abstract Currently, there is a need for the generation of non-opioid analgesics treating chronic pain. Preclinical and clinical studies demonstrate analgesic effects testosterone. However, treatment with testosterone not feasible due to adverse effects. Selective androgen receptor modulators (SARMs) were developed overcome these limitations by minimizing activation androgenic side First, we SARM administration alleviates widespread muscle pain in male female mice. We then SARM-loaded PLGA...