A5008715226- Palliative Care and End-of-Life Issues
- Family and Patient Care in Intensive Care Units
- Bone health and osteoporosis research
- Grief, Bereavement, and Mental Health
- Medical Imaging and Analysis
- Spine and Intervertebral Disc Pathology
- Patient Dignity and Privacy
- Hip disorders and treatments
- Concrete Corrosion and Durability
- HIV/AIDS drug development and treatment
- Interprofessional Education and Collaboration
- Liver Disease Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Pharmacogenetics and Drug Metabolism
- Click Chemistry and Applications
- Simulation-Based Education in Healthcare
- Chemical Synthesis and Analysis
- Hip and Femur Fractures
- Musculoskeletal pain and rehabilitation
- Masonry and Concrete Structural Analysis
- Total Knee Arthroplasty Outcomes
- Cancer-related gene regulation
- HIV Research and Treatment
- Epigenetics and DNA Methylation
- Health and Conflict Studies
Gilead Sciences (United States)
2021-2024
Johns Hopkins Bayview Medical Center
2020-2022
Johns Hopkins University
2018-2022
Johns Hopkins Medicine
2020-2022
Human Sciences Research Council
2021
The University of Kansas Cancer Center
2020
Tenwek Hospital
2019
University of Kansas Medical Center
2013-2017
Madigan Army Medical Center
2016
Beth Israel Deaconess Medical Center
2009-2014
Hepatic VLDL overproduction is a characteristic feature of diabetes and an important contributor to diabetic dyslipidemia. sortilin 1 (Sort1), cellular trafficking receptor, novel regulator plasma lipid metabolism reduces cholesterol triglycerides by inhibiting hepatic apolipoprotein B production. Elevated circulating free fatty acids play key roles in the development This study investigated regulation Sort1 obesity potential implications Results showed that protein was markedly decreased...
Arginine methylation is a common post-translational modification, but its role in regulating protein function poorly understood. This study demonstrates that, TNF receptor-associated factor 6 (TRAF6), an E3 ubiquitin ligase involved innate immune signaling, regulated by reversible arginine range of primary and cultured cells. Under basal conditions, TRAF6 methylated the methyltransferase PRMT1, this inhibits activity, reducing activation toll-like receptor signaling. In response to ligands,...
Palliative care is a values-driven approach for providing holistic individuals and their families enduring serious life-limiting illness. Despite its proven benefits, access acceptance not uniform across society. The genesis of palliative was developed through traditional Western lens, which dictated models interaction communication. As the importance increasingly recognized, barriers to accessing services perceptions relevance appropriateness are being given greater consideration. COVID-19...
We used volumetric quantitative computed tomography (QCT) scans to evaluate bone density (vBMD), geometry, and strength in the thoracic (T8 T10) lumbar (L3 L5) spine determined how these parameters varied with age, sex, spinal region. Participants included 690 participants of Framingham Study, 40 87 years old (mean, 61 years). In both women men, trabecular vBMD declined age similarly for regions, whereas cortical integral vBMD, vertebral strength, compressive force more at than (interaction,...
Lenacapavir sodium (GS-6207-02) is a first-in-class HIV capsid inhibitor. Process development of the four-step final assembly lenacapavir from four synthetic intermediates described here. A bis-bromopyridine core sequentially subjected to an alkynylation, amide coupling with chiral pyrazole carboxylic acid, and Suzuki cross-coupling indazole boronic ester. The step telescoped bis-methanesulfonylation hydrolysis yield API. This report highlights experimental work on sequence establish robust...
The rs738409 G>C single nucleotide polymorphism occurring in the patatin-like phospholipase 3 gene has been identified as a novel genetic marker for hepatic steatosis. Recent studies also associated with fibrosis hepatitis C (HCV). Therefore, we sought to determine impact of donor and recipient genotype on progression after liver transplantation HCV. This cohort study included 101 patients infected HCV who underwent between January 2008, June 2011. Donor genotypes were determined from wedge...
The molecular mechanism of induction cytochromes P4501A1/2 (CYP1A1/2) by a synthetic compound YH439 was studied in rodents as well cultured hepatoma cells. CYP1A1-mediated ethoxyresorufin-O-deethylase activity and amounts its immunoreactive protein were increased time- concentration-dependent manner after single dose (150 mg/kg). Northern blot analyses revealed that rapidly (< or = 2 hr) the levels CYP1A1/2 mRNAs, resulting an increase CYP1A level > 6-fold at 8 hr injection. After...
The coronavirus disease 2019 (COVID-19) pandemic laid bare the immediate need for primary palliative care education many clinicians. Primary clinicians in our health system reported an urgent support advance planning and end-of-life symptom management their vulnerable patients. This article describes design dissemination of using established curriculum development method.To develop a succinct practical toolkit use by during COVID-19 pandemic, focused on 2 key elements: (i) communication...
4563 Background: Cabo targets multiple tyrosine kinases, including VEGFR, MET, and AXL, has been reported to show immunomodulatory properties that may counteract tumor-induced immunosuppression, providing a rationale for combining it with PD-L1 inhibitors like durva. We conducted phase Ib GI basket trial evaluate the safety & efficacy of this regimen in advanced GE adenocarcinoma (GEA), colorectal cancer (CRC), hepatocellular carcinoma (HCC). Methods: Patients received cabo durva 3+3...
This manuscript describes the chemical process development and multi-kilogram synthesis of rovafovir etalafenamide (GS-9131), a phosphonamidate prodrug nucleotide reverse transcriptase inhibitor under investigation for treatment HIV-1 infection. Rovafovir is assembled in four-step sequence beginning from nucleoside core an elaborated alcohol. The assembly starts with decarboxylative elimination β-hydroxyacid to yield corresponding cyclic enol ether, which subsequently coupled functionalized...
High-quality goals of care (GOC) communication is fundamental to providing excellent critical care.Educate medical intensive unit (MICU) clinicians, design and implement workflows relating GOC communication, measure the impact on proficiency rate documentation.Guided by Lean Six Sigma principles, an interprofessional team from palliative tailored a multicomponent intervention-the 3-Act Model training workflow modification-to equip empower pulmonary medicine (PCCM) fellow as clinical lead for...