A5076646363- Connective tissue disorders research
- Cardiovascular Issues in Pregnancy
- Diabetes Management and Research
- Chronic Kidney Disease and Diabetes
- Aortic Disease and Treatment Approaches
- Blood Pressure and Hypertension Studies
- Diabetes Treatment and Management
- Dialysis and Renal Disease Management
- Diabetes Management and Education
Johns Hopkins University
2015
Howard Hughes Medical Institute
2015
University of Surrey
2013
Calcium channel blockers (CCBs) are prescribed to patients with Marfan syndrome for prophylaxis against aortic aneurysm progression, despite limited evidence their efficacy and safety in the disorder. Unexpectedly, mice treated CCBs show accelerated expansion, rupture, premature lethality. This effect is both extracellular signal-regulated kinase (ERK1/2) dependent angiotensin-II type 1 receptor (AT1R) dependent. We have identified protein C beta (PKCβ) as a critical mediator of this pathway...
Chronic kidney disease (CKD) is a known risk factor for cardiovascular events and all-cause mortality. We investigate the relationship between CKD stage, proteinuria, hypertension these adverse outcomes in people with diabetes. also study of who did not have monitoring renal function. A cohort type 1 2 diabetes (N = 35,502) from Quality Improvement Kidney Disease (QICKD) cluster randomised trial was followed up over 2.5 years. composite mortality, events, end stage failure comprised outcome...