A5046440167- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Treatment and Research
- Lung Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Management of metastatic bone disease
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Renal cell carcinoma treatment
- Advanced X-ray and CT Imaging
- Adrenal and Paraganglionic Tumors
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiation Dose and Imaging
- Radiopharmaceutical Chemistry and Applications
- Sarcoma Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Risks and Factors
- Medical Imaging and Pathology Studies
- Bone Tumor Diagnosis and Treatments
- Brain Metastases and Treatment
- Atomic and Subatomic Physics Research
- Boron Compounds in Chemistry
- Spinal Fractures and Fixation Techniques
IRCCS Humanitas Research Hospital
2021-2025
Humanitas University
2020-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2022
Background: Spinal metastases affect approximately 40% of patients with systemic cancers; metastatic epidural spinal cord compression (MESCC) occurs in up to 20% cases and leads potential significant morbidity. Recent advancements high-dose conformal radiation techniques, such as Stereotactic Body Radiation Therapy (SBRT) Radiosurgery (SRS), enable histology-independent ablative treatments, yet optimal dose fractionation remains undetermined. Methods Results: This case vertebral high-grade...
Aims: We report the mature toxicity data of a phase II non-randomized trial on use SBRT for lung and liver oligometastases. Methods: Oligometastatic patients from breast cancer were treated with up to five and/or lesions. Inclusion criteria were: age > 18 years, ECOG 0–2, diagnosis cancer, less than lung/liver lesions (with maximum diameter <5 cm), metastatic disease confined lungs or extrapulmonary extrahepatic stable responding systemic therapy. Various dose–fractionation schedules...
Background: The aim of this study was to investigate the feasibility ultrahypofractionated radiotherapy prostate bed in patients with biochemical and/or clinical relapse following radical prostatectomy who were enrolled prospective, observational, multicentric POPART trial (NCT04831970). Methods: Patients post-radical PSA levels ≥0.1–2.0 ng/mL local at PSMA PET/CT or multiparametric MRI treated Linac-based SBRT on up a total dose 32.5 Gy five fractions every other day (EQD21.5 = 74.2 Gy)....
Few data are available on the role of SBRT re-irradiation for isolated recurrences. We designed a prospective phase I study to evaluate maximum tolerated dose (MTD) thoracic re-irradiation, peripheral lung lesions. RT was delivered with escalation design from 30 Gy in five fractions up 50 fractions. The primary end point definition re-irradiation. dose-limiting toxicity pneumonia ≥G3. Fifteen patients were enrolled. No cases ≥G3 occurred any our cohorts. Only one patient developed G1 during...
Abstract Background In 2016 we published a phase II study exploring safety and efficacy of Stereotactic Body Radiation Therapy (SBRT) delivered with Volumetric Modulated Arc (VMAT) Flattening Filter Free (FFF) beams techniques in prostate cancer (PC) patients. We present herein the updated results on late toxicity long‐term survival. Methods Patients enrolled had biopsy‐confirmed localized PC features low‐ or intermediate‐risk disease (National Comprehensive Network Criteria). The...
This study evaluated the outcome, toxicity and predictive factors in patients unfit for concurrent chemo-radiotherapy (CT-RT) treated with hypofractionated sequential CT-RT or exclusive radiotherapy (RT) locally advanced non-small cell lung cancer (LA-NSCLC).We included affected by LA-NSCLC (stage IIA-IVA) a total dose of 50-60 Gy 20 fractions. The primary outcomes were local control (LC), distant metastasis-free survival (DMFS), progression-free (PFS) overall (OS). Univariate analysis was...
The aim of this study was to evaluate clinical results and prognostic factors in a cohort patient with oligometastatic esophagogastric adenocarcinoma treated stereotactic radiation therapy (SRT).This retrospective included patients affected by 1-3 metastases SRT from 2013 2021. Local control (LC), overall survival (OS), progression-free (PFS), time polymetastatic dissemination (TTPD) systemic change/initiation (TTS) were evaluated.Between 2021, 55 on 80 sites. Median follow-up 20 months....