A5038815587- Crystallization and Solubility Studies
- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Chemical and Physical Properties in Aqueous Solutions
- Pharmacological Effects of Natural Compounds
- Phase Equilibria and Thermodynamics
- Advanced Drug Delivery Systems
- Analytical Methods in Pharmaceuticals
- Protein purification and stability
- Inhalation and Respiratory Drug Delivery
- Diabetes Treatment and Management
- Microencapsulation and Drying Processes
- Education and Learning Interventions
- Silymarin and Mushroom Poisoning
- Nanoparticle-Based Drug Delivery
- Aerosol Filtration and Electrostatic Precipitation
- Mesoporous Materials and Catalysis
- Toxin Mechanisms and Immunotoxins
- Graphene and Nanomaterials Applications
- Polysaccharides and Plant Cell Walls
- Synthesis and bioactivity of alkaloids
- Tea Polyphenols and Effects
- Gastrointestinal motility and disorders
- Pharmacological Effects and Assays
- Nanoparticles: synthesis and applications
Pusan National University
2015-2024
This study aimed to develop an improved sustained-release (SR) PLGA microsphere of exenatide using supercritical fluid extraction emulsions (SFEE). As a translational research, we investigated the effect various process parameters on fabrication exenatide-loaded microspheres by SFEE (ELPM_SFEE) Box-Behnken design (BBD), experiment approach. Further, ELPM obtained under optimized conditions and satisfying all response criteria were compared with prepared conventional solvent evaporation...
The aim of this study was to develop celecoxib-polyvinylpyrrolidone (PVP) solid dispersion nanoparticles with and without surfactant using the supercritical antisolvent (SAS) process. effect different surfactants such as gelucire 44/14, poloxamer 188, 407, Ryoto sugar ester L1695, d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) on nanoparticle formation dissolution well oral absorption celecoxib-PVP K30 investigated. Spherical celecoxib less than 300 nm in size were successfully...
The aim of this study was to prepare pure trans-resveratrol nanoparticles without additives (surfactants, polymers, and sugars) using a supercritical antisolvent (SAS) process with alcohol (methanol or ethanol) dichloromethane mixtures. In addition, in order investigate the effect particle size on dissolution oral bioavailability trans-resveratrol, two microparticles different sizes (1.94 μm 18.75 μm) were prepared milling processes, compared by SAS process. solid-state properties particles...
The purpose of this study was to prepare a dutasteride-loaded solid-supersaturatable self-microemulsifying drug delivery system (SMEDDS) using hydrophilic additives with high oral bioavailability, and determine if there correlation between the in vitro dissolution data vivo pharmacokinetic parameters rats. A SMEDDS generated by adsorption liquid onto Aerosil 200 colloidal silica spray drying process. absorption dutasteride from solid significantly increased after addition hydroxypropylmethyl...