A5065149701- Parasites and Host Interactions
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- 3D Printing in Biomedical Research
- Parasitic Infections and Diagnostics
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- NF-κB Signaling Pathways
- Tuberculosis Research and Epidemiology
- TGF-β signaling in diseases
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Cancer Research and Treatments
- Immune cells in cancer
- Inflammasome and immune disorders
- Asthma and respiratory diseases
- Vector-borne infectious diseases
- CAR-T cell therapy research
- Cancer-related gene regulation
- Lung Cancer Research Studies
- Pancreatic function and diabetes
University of California, San Francisco
2012-2017
City College of San Francisco
2015
Wellcome Centre for Cell-Matrix Research
2010-2013
University of Manchester
2010-2013
Although immune checkpoint inhibitors (ICIs) are established as effective cancer therapies, overcoming therapeutic resistance remains a critical challenge. Here we identify interleukin 6 (IL-6) correlate of poor response to atezolizumab (anti-PD-L1) in large clinical trials advanced kidney, breast, and bladder cancers. In pre-clinical models, combined blockade PD-L1 the IL-6 receptor (IL6R) causes synergistic regression tumors substantially improves anti-tumor CD8+ cytotoxic T lymphocyte...
Bacterial-associated LPS drives oncostatin M–dependent airway inflammation and mucus hypersecretion in severe asthma.
Chronic intestinal parasite infection is a major global health problem, but mechanisms that promote chronicity are poorly understood. Here we describe novel cellular and molecular pathway involved in the development of chronic infection. We show that, early during with murine Trichuris muris, TGFβ signalling CD4+ T-cells induced antibody-mediated inhibition function results protection from Mechanistically, find enhanced involves expression TGFβ-activating integrin αvβ8 by dendritic cells...
Abstract Therapeutic regulatory T cells (Tregs) can reverse pre-established autoimmune pathology. In this study, using a mouse model of diabetes, we aimed to determine the means by which therapeutic Tregs control islet inflammation. Islet Ag-specific infiltrated inflamed islets soon after infusion into prediabetic mice, was quickly followed selective reduction mRNA associated with effector in islets. This change partially due decreased CD8+ cell accumulation tissue. that remained Treg...
Abstract In NOD mice, CD11c+ cells increase greatly with islet inflammation and contribute to autoimmune destruction of pancreatic β cells. this study, we investigated their origin mechanism recruitment. in inflamed islets resembled classical dendritic based on transcriptional profile. However, the majority these were not from Zbtb46-dependent dendritic-cell lineage. Instead, monocyte precursors could give rise islets. Chemokines Ccl5 Ccl8 persistently elevated influx was partially dependent...
<title>Abstract</title> Multicellular cytokine networks orchestrate the onset and progression of intestinal inflammation colitis-associated cancer (CAC). Interleukin 22 (IL-22), a member IL-10 superfamily, is known for its ability to promote epithelial cell recovery repair. However, dysregulation IL-22 can inadvertently fuel tumorigenesis through mechanisms that are not completely understood. Here we show IL-22, derived from group 3 innate lymphoid cells (ILC3), directly triggers oncostatin...
Abstract Fibroblastic reticular cells (FRC) play an important role in maintaining immune homeostasis and orchestrating responses by producing chemokines cytokines that promote cell migration, organization, function, survival secondary lymphoid organs. However, little is known about their function the development maintenance of inflammation tissue. Here we show FRC-like can be found inflamed islets Langerhans type 1 diabetes-prone NOD mice. No FRC are non-inflamed crucially number increases...
Abstract The cytokine TGFβ is crucial in regulating immunity the intestine, but its role and regulation during responses to intestinal infection not well understood. We therefore addressed how functions controlled chronic infection, using model murine parasite Trichuris muris (the human homologue of which affects ~600 million people world-wide, causing severe health problems). found that signalling induced early specifically CD4+ T-cells. This enhanced involves expression TGFβ-activating...
Abstract Recent immunotherapy failures in clinical trials have elucidated the affects of tumor stroma on attenuating therapeutic response. In some cancers, consists a collagen-rich fibrotic zone periphery that traps infiltrating CD8+ T cells, allowing to evade immune cell-mediated death. Typically, animal models are employed study complex physiology. However, known challenges these methods include cost, duration and throughput. Thus, we sought develop 3D vitro model recapitulates exclusion...
Recent immunotherapy failures in clinical trials have elucidated the affects of tumor stroma on attenuating therapeutic response. In some cancers, consists a collagen-rich fibrotic zone periphery that traps infiltrating CD8+ T cells, allowing to evade immune cell-mediated death. Typically, animal models are employed study complex physiology. However, known challenges these methods include cost, duration and throughput. Thus, we sought develop 3D vitro model recapitulates exclusion phenotype...