A5021673373- Mental Health Treatment and Access
- Digital Mental Health Interventions
- Deception detection and forensic psychology
- Treatment of Major Depression
- Schizophrenia research and treatment
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Memory Processes and Influences
- Mental Health and Patient Involvement
- Psychosomatic Disorders and Their Treatments
- Intergenerational Family Dynamics and Caregiving
- Advanced Neuroimaging Techniques and Applications
- Child Abuse and Trauma
- Health Systems, Economic Evaluations, Quality of Life
- Primary Care and Health Outcomes
- Psychology of Moral and Emotional Judgment
- Suicide and Self-Harm Studies
- Health disparities and outcomes
- Child Abuse and Related Trauma
- Attention Deficit Hyperactivity Disorder
- Gun Ownership and Violence Research
The University of Melbourne
2021-2024
Institute of Mental Health
2010-2021
University of Nottingham
2010-2021
National Institute for Health Research
2017
Pieta House
2016
University of Sheffield
2004-2011
Northern General Hospital
2011
United Nations Industrial Development Organization
2008
Texas A&M University
2003
It is challenging to engage repeat users of unscheduled healthcare with severe health anxiety in psychological help and high service costs are incurred. We investigated whether clinical economic outcomes were improved by offering remote cognitive behaviour therapy (RCBT) using videoconferencing or telephone compared treatment as usual (TAU). A single-blind, parallel group, multicentre randomised controlled trial was undertaken primary general hospital care. Participants aged ≥18 years ≥2...
Diagnosis of attention deficit hyperactivity disorder (ADHD) relies on subjective methods which can lead to diagnostic uncertainty and delay. This trial evaluated the impact providing a computerised test activity (QbTest) report speed accuracy decision-making in children with suspected ADHD.Randomised, parallel, single-blind controlled mental health community paediatric clinics England. Participants were 6-17 years-old referred for ADHD assessment; all underwent assessment-as-usual, plus...
Background Antidepressant use has continually increased in recent decades and although they are an effective treatment for moderate-to-severe depression, when there is no longer a clinical benefit, deprescribing should occur. Currently, routine not part of practice research shows that been increase antidepressant users seeking informal support online. This small scoping exercise used mixed-methods online survey to investigate the motives have joining social media groups, what elements groups...
Abstract ‘Munchausen's syndrome by proxy’ characteristically describes women alleged to have fabricated or induced illnesses in children under their care, purportedly attract attention. Where conclusive evidence exists the condition's aetiology remains speculative, where such is lacking diagnosis hinges upon denial of wrong-doing (conduct also compatible with innocence). How might investigators obtain objective guilt innocence? Here, we examine case a woman convicted poisoning child. She...
Lying is ubiquitous and has acquired many names. In 'natural experiments', both pathological lying truthfulness implicate prefrontal cortices. Recently, the advent of functional neuroimaging allowed investigators to study deception in non-pathological state. Prefrontal cortices are again implicated, although regions identified vary across experiments. Forensic application such technology (to detection deceit) requires solution tractable technical problems. Whether we 'should' detect remains...
Background The 17-item Hamilton Depression Rating Scale (HDRS17) is used world-wide as an observer-rated measure of depression in randomised controlled trials (RCTs) despite continued uncertainty regarding its factor structure. This study investigated the dimensionality HDRS17 for patients undergoing treatment UK mental health settings with moderate to severe persistent major depressive disorder (PMDD). Methods Exploratory Structural Equational Modelling (ESEM) was performed examine...
Introduction The National Institute for Health and Care Excellence (NICE) guidelines attention deficit/hyperactivity disorder (ADHD) state that young people need to have access the best evidence-based care improve outcome. current ‘gold standard’ ADHD diagnostic assessment combines clinical observation with subjective parent, teacher self-reports. In routine practice, reports from multiple informants may be unavailable or contradictory, leading uncertainty delay. addition of objective tests...
Self-harm and depression are strong risk factors for repeat self-harm suicide. We aimed to investigate the feasibility of a randomised controlled trial (RCT) remotely delivered problem-solving cognitive behaviour therapy (PSCBT) plus treatment as usual (TAU) versus TAU in young people with depression. Single-blind multi-centre RCT an internal pilot, pre-set stop-go criteria qualitative semi-structured interviews. Eligible participants (aged 16–30 years) were recruited from 9 adult or child...
Abstract Background: Current treatment guidelines advise that the deprescribing of antidepressants should occur around 6 months post-remission symptoms. However, this is not routinely occurring in clinical practice, with between 30% and 50% antidepressant users potentially continuing no benefit. To support patients to deprescribe when clinically appropriate, it important understand what making decision reduce or cease a naturalistic setting. Aim: The current study aimed describe...
Effective help for depression and anxiety reaches a small proportion of people who might benefit from it. The scale the problem suggests need effective, safe web-based public health services delivered directly to public. One model, Big White Wall (BWW), offers peer support at low cost. As these interventions are digitally, we tested whether randomized controlled trial (RCT) intervention could also be fully evaluated digitally.This study aims determine reach, feasibility, acceptability,...
Lying and deception are common human activities may occur in a wide variety of clinical contexts. These behaviours implicate higher neural systems within the brains humans other primates. Recent functional neuroimaging studies suggest that prefrontal anterior cingulate cortices particularly engaged during certain forms deception, hence, executive processes support deceit. Congruent with latter position is finding lies take longer to execute than truthful responses. To date, no study has...
Around 40 per cent of patients with unipolar depressive disorder who are treated in secondary care mental health services do not respond to first or second line treatments for depression. Such have 20 times the suicide rate general population and treatment response becomes harder achieve sustain longer they remain depressed. Despite this there no randomised controlled trials community based service delivery interventions delivering both algorithm pharmacotherapy psychotherapy chronic...
A recently emergent functional neuroimaging literature has described the anatomical correlates of deception among healthy volunteers, most often implicating ventrolateral prefrontal and anterior cingulate cortices. To date, there have been no such imaging studies people with severe mental illness.To discover whether brains schizophrenia would manifest a similar distinction between states truthfulness deceit. It is hypothesised that, as people, persons will show activation in cortices when...
Introduction The BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action connectivity guided intermittent theta burst stimulation (cgiTBS) versus standard repetitive transcranial magnetic (rTMS) in adults with moderate severe treatment resistant depression. Methods analysis is a randomised double-blind controlled trial 1:1 allocation either 20 sessions (1) cgiTBS or (2) neuronavigated rTMS not using guidance. A total 368 eligible participants...
Free association has been central to psychoanalytic theory and practice for over a century, yet its physiology largely ignored. When viewed from cognitive neurobiological perspective, the process resembles minimally constrained executive task, one that might engage left dorsolateral prefrontal cortex. To test this hypothesis, we used functional magnetic resonance imaging detect neural activity while subjects performed overt, vocal free in scanner. Twelve healthy three active tasks—vocal...
Regardless of geography or income, effective help for depression and anxiety only reaches a small proportion those who might benefit from it. The scale the problem suggests role effective, safe, anonymized public health-driven Web-based services such as Big White Wall (BWW), which offer immediate peer support at low cost.Using Reach, Effectiveness, Adoption, Implementation Maintenance (RE-AIM) methodology, aim this study was to determine population reach, effectiveness, cost-effectiveness,...
A specialist depression service (SDS) offering collaborative pharmacological and cognitive behaviour therapy treatment for persistent depressive disorder showed effectiveness against symptoms versus usual community based multidisciplinary care in a randomised controlled trial (RCT) mental health services England. However, there is uncertainty concerning how effect such change. The current study aimed to evaluate the factors which may explain greater of SDS compared Treatment as Usual (TAU)...