A5003224227- Autophagy in Disease and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Calcium signaling and nucleotide metabolism
- Pancreatic function and diabetes
- Ubiquitin and proteasome pathways
- Polyamine Metabolism and Applications
- Metabolism, Diabetes, and Cancer
- Wnt/β-catenin signaling in development and cancer
- Cannabis and Cannabinoid Research
- Cellular transport and secretion
- Microtubule and mitosis dynamics
- CRISPR and Genetic Engineering
- Cytokine Signaling Pathways and Interactions
- Hippo pathway signaling and YAP/TAZ
- Phagocytosis and Immune Regulation
- Adenosine and Purinergic Signaling
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Immune Cell Function and Interaction
- Sirtuins and Resveratrol in Medicine
- Nausea and vomiting management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- T-cell and B-cell Immunology
University of Ottawa
2017-2025
Institute of Infection and Immunity
2018-2025
Centre for Infection, Immunity and Inflammation
2021-2025
Baylor Scott & White Medical Center - Temple
2023
University of California, San Diego
2011-2015
Moores Cancer Center
2011-2015
La Jolla Alcohol Research
2013
University of Toronto
2006-2011
Canada Research Chairs
2006-2008
BC Cancer Agency
2005
Getting specific about amino acid sensing The protein kinase complex mTORC1 regulates growth and metabolism, its activity is controlled in response to the abundance of cellular acids. Jewell et al. report that control glutamine does not require Rag guanosine triphosphatase (GTPase) implicated other acids such as leucine (see Perspective by Abraham). For glutamine, another GTPase, Arf1, was required. Distinct mechanisms thus appear couple various signaling complex. Science , this issue p. 194...
Autophagy is a cellular defense response to stress conditions, such as nutrient starvation. The type III phosphatidylinositol (PtdIns) 3-kinase, whose catalytic subunit PIK3C3/VPS34, plays critical role in intracellular membrane trafficking and autophagy induction. PIK3C3 forms multiple complexes the ATG14-containing specifically involved Mechanistic target of rapamycin (MTOR) complex 1, MTORC1, key sensor integrator stimulate anabolism inhibit catabolism. Inactivation TORC1 by starvation In...
The product of the von Hippel-Lindau gene (VHL) acts as substrate-recognition component an E3 ubiquitin ligase complex that ubiquitylates catalytic alpha subunit hypoxia-inducible factor (HIF) for oxygen-dependent destruction. Although emerging evidence supports notion deregulated accumulation HIF upon loss VHL is crucial development clear-cell renal cell carcinoma (CC-RCC), molecular events downstream governing oncogenesis remain unclear. Here, we show expression a homophilic adhesion...
Abstract Cytosolic lipid droplets (LDs) regulate homeostasis, with abnormal LD dynamics linked to metabolic diseases like atherosclerosis. In macrophage foam cells, LDs undergo autophagic degradation via lipophagy, but the extent of this process in vascular smooth muscle cell (VSMC) cells remains unclear. To track lipophagy real time, we developed a Rosella-PLIN2 biosensor by tagging perilipin 2 (PLIN2) fluorescent pH-biosensor Rosella. We show that proatherogenic lipoproteins and autophagy...
Inhibiting the glutamate receptor mGluR5 may prevent progression of neuronal loss and motor impairment in patients with Huntington’s disease.
The autophagy pathway is an essential facet of the innate immune response, capable rapidly targeting intracellular bacteria. However, initial signaling regulating induction in response to pathogens remains largely unclear. Here, we report that AMPK, upstream activator pathway, stimulated upon detection pathogenic bacteria, before bacterial invasion. Bacterial recognition occurs through outer membrane vesicles. We found AMPK relieves mTORC1-mediated repression infection, positioning cell for...
Abstract Human and mouse NK cells use different families of receptors to recognize MHC class I (MHC I) on target cells. Although human express both Ig-like lectin-like specific for I, all the I-specific identified date are receptors, no recognizing have been In this study we report first receptor cells, namely, murine CD160 (mCD160). The expression mCD160 is restricted a subset NK1.1+ T activated CD8+ mCD160-Ig fusion protein binds rat cell lines transfected with classical nonclassical...
Chromosomal abnormalities, such as structural and numerical are a common occurrence in cancer. The close association of homologous chromosomes during interphase, phenomenon termed somatic chromosome pairing, has been observed cancerous cells, but the functional consequences pairing have not established. Gene expression profiling studies revealed that 19 is recurrent chromosomal abnormality renal oncocytoma, neoplasia adult kidney. Somatic was associated with significant disruption gene...